AR018605A1 - Compuestos de 1,2-dihidro-indazol-3-onas 1,2,5-trisustituidas y sus sales, procedimientos para prepararlas, uso de dichos compuestos para la preparacion demedicamentos y las composiciones farmaceuticas que los contienen - Google Patents

Compuestos de 1,2-dihidro-indazol-3-onas 1,2,5-trisustituidas y sus sales, procedimientos para prepararlas, uso de dichos compuestos para la preparacion demedicamentos y las composiciones farmaceuticas que los contienen

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Publication number
AR018605A1
AR018605A1 ARP990102212A ARP990102212A AR018605A1 AR 018605 A1 AR018605 A1 AR 018605A1 AR P990102212 A ARP990102212 A AR P990102212A AR P990102212 A ARP990102212 A AR P990102212A AR 018605 A1 AR018605 A1 AR 018605A1
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AR
Argentina
Prior art keywords
alkyl
aryl
compounds
unsaturated
choh
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ARP990102212A
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English (en)
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Dresden Arzneimittel
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Publication of AR018605A1 publication Critical patent/AR018605A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen 1,2-dihidro-indazol-3-onas 1,2,5-trisustituidas, de donde X, Y, Z, R1, R2, y R3 tienen el siguiente significado: X puede ser -SO2-, SO-,-(CH2)p-, -(CH2)p-O-, (CH2)p-(C=O)- -(CH2)p-(C=O)-NH, -(CH2)p-CHOH-, -CHOH-(CH2)p-, -(CH2)p-CH=CH-, CH=CH-(CH2)p- con p=1 a 4, Y puede ser -(C=O)-, (C=O)-NH,-(C=O)-NH-(CH2)p-, -(C=O)-(CH2)p, -(CH2)p-, -(CH2)p-O-, (CH2)p-(C=O), -(CH2)p-(C=O)-NH-, (CH2)p-(C=O)-NH-(CH2)p-, (CH2)p-CHOH-, -CHOH-(CH2)p-, (CH2)p-CH=CH,CH=CH-(CH2)p-con p = 1 A 4, Z puede ser -O-, -O-(CH2)p- con p=1 a 4, -NH-, -NH-(C=O), -NH-(C=O)-NH, -NH-(C=O)-O-, -NH-CH2-(C=O)- y -NH-(C=O)-CH2, R1, R2 y R3pueden ser iguales o diferentes y pueden tener el siguiente significado: Carbociclos mono, bi o tricíclicos saturados o una o más veces insaturados, con 5 a 14eslabones, especialmente fenilo, naftilo, antranilo, fluorenilo; o heterociclos mono, bi o tricíclicos saturados o una o más veces insaturados, con 5-15eslabones y 1 a 6 heteroátomos que preferentemente son N, O y S, especialmente tiofenilo, piridinilo, isoxazolilo, benzimidazolilo, benz[1,3]dioxolilo,pirimidinilo, quinolilo, quinazolilnilo, morfolinilo, pirrolidinilo, pirrolilo, fenil [1,2,4]oxadiazolilo, feniltiazolilo, donde los carbociclos o, en su casolos heterociclos pueden estar una o más veces sustituidos por -C1-6-alquilo, -O-C1-6-alquilo, -O-C3-7-cicloalquilo, carbociclos mono, bi o tricíclicossaturados o una o más veces insaturados, con 3 a 14 eslabones, heterociclos, mono, bi o tricíclicos saturados ouna o más veces insaturados, con 5 a 15eslabones y 1 a 6 heteroátomos que preferentemente son N, O y S, -F, -Cl, Br, -I, -OH, SH, -NO2, NH2, -NHC1-6-alquilo, -N(C1-6alquilo)2, -NHC6-14-arilo,-N(C6-14-arilo)2, -N(C1-6-alquil)(C6-14-arilo), -NHCOC1-6-alquilo, -NHCOC6-14-arilo, -CONHC1-6-alquilo, -CONHC6-14-arilo, -CONHSO2C1-6-alquilo, -CONHSO2C6-14-arilo, CN, -(CO)C1-6-alquilo, -(CS)C1-6-alquilo, -COOH, -COOC-6-alquilo, -O-C6-14-arilo, -O-(CO)C1-6-alquilo, -O-(CO)C6-14-arilo, bencilo, benciloxi,-S-C1-6-alquilo, -S-C6-14-arilo, -CF3, (CH2)p-COOH con p=1 a 4, -(CH2)p-COOC1-6-aluilo con p= 1 a 4, -SO2-C1-6-alquilo, -SO2-C6-14 arilo, R1 además puede ser H (aunque
ARP990102212A 1998-05-11 1999-05-11 Compuestos de 1,2-dihidro-indazol-3-onas 1,2,5-trisustituidas y sus sales, procedimientos para prepararlas, uso de dichos compuestos para la preparacion demedicamentos y las composiciones farmaceuticas que los contienen AR018605A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19821003A DE19821003A1 (de) 1998-05-11 1998-05-11 Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
AR018605A1 true AR018605A1 (es) 2001-11-28

Family

ID=7867363

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102212A AR018605A1 (es) 1998-05-11 1999-05-11 Compuestos de 1,2-dihidro-indazol-3-onas 1,2,5-trisustituidas y sus sales, procedimientos para prepararlas, uso de dichos compuestos para la preparacion demedicamentos y las composiciones farmaceuticas que los contienen

Country Status (23)

Country Link
US (1) US6180637B1 (es)
EP (1) EP1077948A1 (es)
JP (1) JP2002514627A (es)
KR (1) KR20010025011A (es)
CN (1) CN1309642A (es)
AR (1) AR018605A1 (es)
AU (1) AU745796B2 (es)
BG (1) BG104910A (es)
BR (1) BR9911772A (es)
CA (1) CA2271837A1 (es)
CO (1) CO5021131A1 (es)
DE (1) DE19821003A1 (es)
HK (1) HK1038751A1 (es)
HU (1) HUP0101707A3 (es)
IL (1) IL139358A0 (es)
NO (1) NO20005698L (es)
NZ (1) NZ508646A (es)
PL (1) PL344254A1 (es)
SK (1) SK17082000A3 (es)
TR (1) TR200003302T2 (es)
TW (1) TW448163B (es)
WO (1) WO1999058504A1 (es)
ZA (1) ZA200006151B (es)

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US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) * 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
WO2008141385A1 (en) * 2007-05-21 2008-11-27 Biota Scientific Management Pty Ltd Viral polymerase inhibitors
SG193454A1 (en) 2011-03-14 2013-10-30 Boehringer Ingelheim Int Benzodioxane inhibitors of leukotriene production
WO2013012844A1 (en) 2011-07-19 2013-01-24 Boehringer Ingelheim International Gmbh Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
TW201350475A (zh) 2012-03-06 2013-12-16 Boehringer Ingelheim Int 用於組合療法之白三烯素生成之苯并二噁烷抑制劑
US8946203B2 (en) 2012-03-06 2015-02-03 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production
JP6256467B2 (ja) 2012-07-17 2018-01-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成を阻害するピラゾール誘導体
JP2016523982A (ja) 2013-07-15 2016-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
EP3022193B1 (en) 2013-07-15 2017-04-26 Boehringer Ingelheim International GmbH Inhibitors of leukotriene production
KR20190017873A (ko) * 2016-06-08 2019-02-20 썬리겐 헬쓰케어 아게 홀수의 탄소 원자를 갖는 지질 및 제약 조성물 또는 영양 보충제로서의 그의 용도
CN113105409B (zh) * 2021-04-06 2023-06-02 四川大学 2-(羟基苄基)苯并[d]异噻唑酮类化合物、其制备方法和用途
CA3221177A1 (en) 2021-11-01 2023-05-04 Meghan Kerrisk Campbell Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

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DE3132916A1 (de) * 1981-08-20 1983-03-03 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5179112A (en) * 1985-04-17 1993-01-12 Ici Americas Inc. Heterocyclic amide derivatives and pharmaceutical use
IL84944A (en) * 1987-01-19 1992-02-16 Ici Plc Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
US5036083A (en) * 1988-07-15 1991-07-30 Ici Pharma Heterocyclic agents
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DE19610882A1 (de) * 1996-03-20 1997-09-25 Dresden Arzneimittel Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
HUP0101707A2 (hu) 2002-03-28
NO20005698D0 (no) 2000-11-10
CO5021131A1 (es) 2001-03-27
ZA200006151B (en) 2000-12-06
NZ508646A (en) 2002-11-26
HUP0101707A3 (en) 2002-06-28
DE19821003A1 (de) 1999-11-18
CA2271837A1 (en) 1999-11-11
JP2002514627A (ja) 2002-05-21
WO1999058504A9 (de) 2000-02-03
SK17082000A3 (sk) 2001-09-11
AU745796B2 (en) 2002-03-28
TW448163B (en) 2001-08-01
CN1309642A (zh) 2001-08-22
AU4257699A (en) 1999-11-29
BG104910A (en) 2001-06-29
WO1999058504A1 (de) 1999-11-18
PL344254A1 (en) 2001-10-22
IL139358A0 (en) 2001-11-25
BR9911772A (pt) 2001-02-06
NO20005698L (no) 2001-01-08
EP1077948A1 (de) 2001-02-28
HK1038751A1 (zh) 2002-03-28
TR200003302T2 (tr) 2001-02-21
KR20010025011A (ko) 2001-03-26
US6180637B1 (en) 2001-01-30

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