CO5060424A1 - Nuevos 1h-indazoles 1,5 y 3-0 sustituidos con efecto antias- matico, antialergico, antiinflamatorio, inmunomodulador y neuroprotector, procedimientos para su elaboracion y su aplicacion como medicamentos - Google Patents

Nuevos 1h-indazoles 1,5 y 3-0 sustituidos con efecto antias- matico, antialergico, antiinflamatorio, inmunomodulador y neuroprotector, procedimientos para su elaboracion y su aplicacion como medicamentos

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Publication number
CO5060424A1
CO5060424A1 CO99028289A CO99028289A CO5060424A1 CO 5060424 A1 CO5060424 A1 CO 5060424A1 CO 99028289 A CO99028289 A CO 99028289A CO 99028289 A CO99028289 A CO 99028289A CO 5060424 A1 CO5060424 A1 CO 5060424A1
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Colombia
Prior art keywords
indazoles
choh
neuroprotector
immunomodulator
medications
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Application number
CO99028289A
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English (en)
Inventor
Rudolf Schindler
Norbert Hofgen
Brune Kay
Original Assignee
Dresden Arzneimittel
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Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of CO5060424A1 publication Critical patent/CO5060424A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
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    • B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
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    • B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
    • B65B37/16—Separating measured quantities from supply
    • B65B37/18—Separating measured quantities from supply by weighing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
    • B65B37/16—Separating measured quantities from supply
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
    • B65B39/001—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers with flow cut-off means, e.g. valves
    • B65B39/003—Rotating means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/10—Enclosing successive articles, or quantities of material, in preformed tubular webs, or in webs formed into tubes around filling nozzles, e.g. extruded tubular webs
    • B65B9/20—Enclosing successive articles, or quantities of material, in preformed tubular webs, or in webs formed into tubes around filling nozzles, e.g. extruded tubular webs the webs being formed into tubes in situ around the filling nozzles
    • B65B9/213—Enclosing successive articles, or quantities of material, in preformed tubular webs, or in webs formed into tubes around filling nozzles, e.g. extruded tubular webs the webs being formed into tubes in situ around the filling nozzles the web having intermittent motion
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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    • C07—ORGANIC CHEMISTRY
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Nuevos 1H-indazoles 1, 5 y 3-0- sustituidos caracterizados porquetienen la fórmula general Idonde X, Y, Z, R1 , R2 , y R3 tienen el siguiente significado:X puede ser -SO2 -, -SO-, -(CH2 )p -, -(CH2 )p -O-, -(CH2 )p -(C=O)- -(CH2 )p -(C=O)-NH, -(CH2 )p -CHOH-, -CHOH-(CH2 )p -, -(CH2 )p -CH=CH-, - CH=CH-(CH2 )p -con p = 1...4,Y puede ser -(CH2 )p -, -(CH2 )p -O-, -(CH2 )p -(C=O), -(CH2 )p -(C=O)-NH-, -(CH2 )p -(C=O)-NH-(CH2 )p -, -(CH2 )p -CHOH-, -CHOH-(CH2 )p -, -(CH2 )p -CH=CH, -CH=CH-(CH2 )p - con p = 1...4,Z pude ser -O-, -S-, -SO-, -SO2 -, -O-(CH2 )p - con p = 1...4,-NH-, -NH-(C=O), -NH-(C=O)-NH, -NH-(C=O)-O-, -NH-CH2 -(C=O)- y -NH-(C=O)-CH2 , R1 , R2 y R3 pueden ser iguales o diferentes y pueden tener el siguiente significado:Carbociclos mono, bi o tricíclicos saturados o una o más veces insaturados, con 5...14 eslabones, especialmente fenilo, naftilo, antranilo, fluorenilo; o heterociclos mono, bi o tricíclicos saturados o una o más veces insaturados, con 5...15 eslabones y 1...6 heteroátomos que preferentemente son N, O y S, especialmente tiofenilo, piridinilo, isoxazolilo, benzimidazolilo, benz[1,3]dioxolilo, pirimidinilo, quinililo, quinazolinilo, morfolinilo, pirrolidinilo, fenil [1,2,4]oxadiazolilo, feniltiazolilo,donde los carbociclos o, en su caso, los heterociclos ...
CO99028289A 1998-05-11 1999-05-07 Nuevos 1h-indazoles 1,5 y 3-0 sustituidos con efecto antias- matico, antialergico, antiinflamatorio, inmunomodulador y neuroprotector, procedimientos para su elaboracion y su aplicacion como medicamentos CO5060424A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19821002A DE19821002A1 (de) 1998-05-11 1998-05-11 Neue 1,5- und 3-O-substituierte 1H-Indazole mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

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CO5060424A1 true CO5060424A1 (es) 2001-07-30

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CO99028289A CO5060424A1 (es) 1998-05-11 1999-05-07 Nuevos 1h-indazoles 1,5 y 3-0 sustituidos con efecto antias- matico, antialergico, antiinflamatorio, inmunomodulador y neuroprotector, procedimientos para su elaboracion y su aplicacion como medicamentos

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US (1) US6166023A (es)
EP (1) EP1077947B1 (es)
JP (1) JP2002514626A (es)
KR (1) KR20010034853A (es)
CN (1) CN1305462A (es)
AR (1) AR018347A1 (es)
AT (1) ATE248821T1 (es)
AU (1) AU754401B2 (es)
BG (1) BG104908A (es)
BR (1) BR9911787A (es)
CA (1) CA2271831A1 (es)
CO (1) CO5060424A1 (es)
DE (2) DE19821002A1 (es)
HU (1) HUP0101821A3 (es)
IL (1) IL139359A0 (es)
NO (1) NO20005699L (es)
NZ (1) NZ508647A (es)
PL (1) PL344255A1 (es)
SK (1) SK17092000A3 (es)
TR (1) TR200003303T2 (es)
TW (1) TW509681B (es)
WO (1) WO1999058503A1 (es)
ZA (1) ZA200006153B (es)

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US20040048866A1 (en) * 2002-03-08 2004-03-11 Teodozyj Kolasa Indazole derivatives that are activators of soluble guanylate cyclase
US7417063B2 (en) * 2004-04-13 2008-08-26 Bristol-Myers Squibb Company Bicyclic heterocycles useful as serine protease inhibitors
WO2006056873A2 (en) 2004-11-29 2006-06-01 Warner-Lambert Company Llc Therapeutic pyrazolo[3,4-b] pyridines and indazoles
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US9108948B2 (en) * 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
JP5203360B2 (ja) * 2006-06-23 2013-06-05 アボット・ラボラトリーズ ヒスタミンｈ３受容体調節剤としてのシクロプロピルアミン誘導体
PE20090159A1 (es) 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
US9149463B2 (en) * 2007-09-18 2015-10-06 The Board Of Trustees Of The Leland Standford Junior University Methods and compositions of treating a Flaviviridae family viral infection
WO2009071483A1 (en) * 2007-12-07 2009-06-11 Via Pharmaceuticals, Inc. 1- (indaz0l-5-yl) -ureas as diacylglycerol acyltransferase inhibitors
CA2742306A1 (en) * 2008-11-03 2010-05-06 Chemocentryx, Inc. Compounds for the treatment of osteoporosis and cancers
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives

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DE59906874D1 (de) 2003-10-09
CA2271831A1 (en) 1999-11-11
JP2002514626A (ja) 2002-05-21
AR018347A1 (es) 2001-11-14
NO20005699L (no) 2001-01-08
AU4499599A (en) 1999-11-29
BR9911787A (pt) 2001-04-03
AU754401B2 (en) 2002-11-14
US6166023A (en) 2000-12-26
HUP0101821A3 (en) 2002-05-28
PL344255A1 (en) 2001-10-22
SK17092000A3 (sk) 2001-08-06
IL139359A0 (en) 2001-11-25
NO20005699D0 (no) 2000-11-10
WO1999058503A1 (de) 1999-11-18
CN1305462A (zh) 2001-07-25
EP1077947A1 (de) 2001-02-28
DE19821002A1 (de) 1999-11-18
HUP0101821A2 (hu) 2002-03-28
TR200003303T2 (tr) 2001-01-22
TW509681B (en) 2002-11-11
ZA200006153B (en) 2000-12-06
KR20010034853A (ko) 2001-04-25
ATE248821T1 (de) 2003-09-15
EP1077947B1 (de) 2003-09-03
BG104908A (bg) 2001-07-31
NZ508647A (en) 2003-05-30

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