HUP0101707A2 - Új antiasztmás, antiallergiás, gyulladásgátló, immunmoduláló és neuroprotektív hatású 1,2,5-szubsztituált 1,2-dihidroindazol-3-on-származékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Új antiasztmás, antiallergiás, gyulladásgátló, immunmoduláló és neuroprotektív hatású 1,2,5-szubsztituált 1,2-dihidroindazol-3-on-származékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0101707A2
HUP0101707A2 HU0101707A HUP0101707A HUP0101707A2 HU P0101707 A2 HUP0101707 A2 HU P0101707A2 HU 0101707 A HU0101707 A HU 0101707A HU P0101707 A HUP0101707 A HU P0101707A HU P0101707 A2 HUP0101707 A2 HU P0101707A2
Authority
HU
Hungary
Prior art keywords
choh
mono
asthmatic
indazol
allergic
Prior art date
Application number
HU0101707A
Other languages
English (en)
Inventor
Kay Brune
Norbert Höfgen
Hildegard Poppe
Rudolf Schindler
Original Assignee
Arzneimittelwerk Dresden Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden Gmbh filed Critical Arzneimittelwerk Dresden Gmbh
Publication of HUP0101707A2 publication Critical patent/HUP0101707A2/hu
Publication of HUP0101707A3 publication Critical patent/HUP0101707A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány új (I) általános képletű 1,2,5-szubsztituált 1,2-dihidro-indazol-3-on-származékokra - ahol a képletben X jelentése -SO2-, -SO-,-(CH2)p-, -(CH2)p-O-, -(CH2)p-(C=O)-, -(CH2)p-(C=O)-NH-, -(CH2)p-CHOH-, -CHOH-(CH2)p-, -(CH2)p-CH=CH-, -CH=CH-(CH2)p- lehet, ahol pértéke 1, 2, 3 vagy 4, Y jelentése -(C=O)-, -(C=O)-NH-, -(C=O)-NH-(CH2)p-, -(C=O)-(CH2)p-, -(CH2)p-O-, -(CH2)p-(C=O)-, -(CH2)p--(C=O)-NH-, -(CH2)p-(C=O)-NH-(CH2)p-, -(CH2)p-CHOH-, -CHOH-(CH2)p-, -(CH2)p-CH=CH-, -CH=CH-(CH2)p- lehet, ahol p értéke 1, 2, 3 vagy 4, Zjelentése -O-, -O-(CH2)p- (p=1, 2, 3 vagy 4) vagy -NH-, -NH-(C=O)-, -NH-(C=O)-NH-, -NH-(C=O)-O-, -NH-CH2-(C=O)- vagy -NH-(C=O)-CH2, R1, R2és R3 jelentése azonos vagy eltérő és az alábbi lehet: 5-14gyűrűtagból álló mono-, bi- vagy triciklusos, telített vagyegyszeresen vagy többszörösen telítetlen karbociklus, előnyösenfenil-, naftil-, antranil-, fluorenilcsoport, 5-15 gyűrűtagból állómono-, bi- vagy triciklusos, telített vagy egyszeresen vagytöbbszörösen telítetlen, 1-6 heteroatomot, előnyösen N-, O- és/vagy S-atomot tartalmazó heterociklusos csoport, előnyösen tienil-,piridinil-, izoxazolil-, benziomidazolil-, benz[1,3]dioxolil-,pirimidinil-, kinolil-, kinazolinil-, morfolinil-, pirrolidinil-,pirrolil-, fenil[1,2,4]oxadiazolil- vagy feniltiazolilcsoport, és akarbociklusos, illetve heterociklusos csoportok lehetnek egyszeresenvagy többszörösen szubsztituáltak - előállításukra és gyógyászatihatóanyagkénti alkalmazásukra vonatkozik. A vegyületeknek antiasztmás,antiallergiás, gyulladásgátló és immunmoduláló tulajdonságai vannak. Ó
HU0101707A 1998-05-11 1999-04-01 Novel 1,2,5-trisubstituted 1,2-dihydro-indazol-3-ones with anti-asthmatic, anti-allergic, anti-inflammatory, immuno-modulating and neuro-protective effect, method for the production them and pharmaceutical compositions containing them HUP0101707A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19821003A DE19821003A1 (de) 1998-05-11 1998-05-11 Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/002291 WO1999058504A1 (de) 1998-05-11 1999-04-01 Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver wirkung, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
HUP0101707A2 true HUP0101707A2 (hu) 2002-03-28
HUP0101707A3 HUP0101707A3 (en) 2002-06-28

Family

ID=7867363

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101707A HUP0101707A3 (en) 1998-05-11 1999-04-01 Novel 1,2,5-trisubstituted 1,2-dihydro-indazol-3-ones with anti-asthmatic, anti-allergic, anti-inflammatory, immuno-modulating and neuro-protective effect, method for the production them and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (1) US6180637B1 (hu)
EP (1) EP1077948A1 (hu)
JP (1) JP2002514627A (hu)
KR (1) KR20010025011A (hu)
CN (1) CN1309642A (hu)
AR (1) AR018605A1 (hu)
AU (1) AU745796B2 (hu)
BG (1) BG104910A (hu)
BR (1) BR9911772A (hu)
CA (1) CA2271837A1 (hu)
CO (1) CO5021131A1 (hu)
DE (1) DE19821003A1 (hu)
HK (1) HK1038751A1 (hu)
HU (1) HUP0101707A3 (hu)
IL (1) IL139358A0 (hu)
NO (1) NO20005698L (hu)
NZ (1) NZ508646A (hu)
PL (1) PL344254A1 (hu)
SK (1) SK17082000A3 (hu)
TR (1) TR200003302T2 (hu)
TW (1) TW448163B (hu)
WO (1) WO1999058504A1 (hu)
ZA (1) ZA200006151B (hu)

Families Citing this family (13)

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US6417189B1 (en) * 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
WO2008141385A1 (en) * 2007-05-21 2008-11-27 Biota Scientific Management Pty Ltd Viral polymerase inhibitors
JP5640162B2 (ja) 2011-03-14 2014-12-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾジオキサンインヒビター
WO2013012844A1 (en) 2011-07-19 2013-01-24 Boehringer Ingelheim International Gmbh Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
WO2013134226A1 (en) 2012-03-06 2013-09-12 Boehringer Ingelheim International Gmbh Benzodioxanes for inhibiting leukotriene production
EP2822941B1 (en) 2012-03-06 2017-05-10 Boehringer Ingelheim International GmbH Benzodioxanes in combination with statins for inhibiting leukotriene production
EP2885285B1 (en) 2012-07-17 2016-10-19 Boehringer Ingelheim International GmbH Pyrazole drivatives which inhibit leukotriene production
EP3022193B1 (en) 2013-07-15 2017-04-26 Boehringer Ingelheim International GmbH Inhibitors of leukotriene production
WO2015009611A1 (en) 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
WO2017211274A1 (en) * 2016-06-08 2017-12-14 Dong Yuhong Lipids with odd number of carbon atoms and their use as pharmaceutical composition or nutritional supplement
CN113105409B (zh) * 2021-04-06 2023-06-02 四川大学 2-(羟基苄基)苯并[d]异噻唑酮类化合物、其制备方法和用途
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

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DE3132916A1 (de) * 1981-08-20 1983-03-03 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5179112A (en) * 1985-04-17 1993-01-12 Ici Americas Inc. Heterocyclic amide derivatives and pharmaceutical use
IL84944A (en) * 1987-01-19 1992-02-16 Ici Plc Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
US5229408A (en) * 1988-07-15 1993-07-20 Ici Pharma 4-carbamoyl-1,2-dihydro-3H-indazol-3-one derivatives
US5036083A (en) * 1988-07-15 1991-07-30 Ici Pharma Heterocyclic agents
DE19610882A1 (de) * 1996-03-20 1997-09-25 Dresden Arzneimittel Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
BG104910A (en) 2001-06-29
JP2002514627A (ja) 2002-05-21
IL139358A0 (en) 2001-11-25
BR9911772A (pt) 2001-02-06
NO20005698D0 (no) 2000-11-10
HK1038751A1 (zh) 2002-03-28
AU745796B2 (en) 2002-03-28
TR200003302T2 (tr) 2001-02-21
SK17082000A3 (sk) 2001-09-11
EP1077948A1 (de) 2001-02-28
CA2271837A1 (en) 1999-11-11
NO20005698L (no) 2001-01-08
DE19821003A1 (de) 1999-11-18
AU4257699A (en) 1999-11-29
KR20010025011A (ko) 2001-03-26
TW448163B (en) 2001-08-01
CN1309642A (zh) 2001-08-22
CO5021131A1 (es) 2001-03-27
WO1999058504A1 (de) 1999-11-18
PL344254A1 (en) 2001-10-22
WO1999058504A9 (de) 2000-02-03
ZA200006151B (en) 2000-12-06
US6180637B1 (en) 2001-01-30
AR018605A1 (es) 2001-11-28
NZ508646A (en) 2002-11-26
HUP0101707A3 (en) 2002-06-28

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