AR018370A1 - Inhibidores de proteasas, composiciones farmaceuticas que lo comprenden, uso de los mismos para la manufactura de un medicamento - Google Patents
Inhibidores de proteasas, composiciones farmaceuticas que lo comprenden, uso de los mismos para la manufactura de un medicamentoInfo
- Publication number
- AR018370A1 AR018370A1 ARP990102442A ARP990102442A AR018370A1 AR 018370 A1 AR018370 A1 AR 018370A1 AR P990102442 A ARP990102442 A AR P990102442A AR P990102442 A ARP990102442 A AR P990102442A AR 018370 A1 AR018370 A1 AR 018370A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- thiophene
- alkoxy
- benzoxazole
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- -1 alkyl pyrazole Chemical compound 0.000 abstract 7
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 6
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical group C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 abstract 4
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 4
- 125000001624 naphthyl group Chemical group 0.000 abstract 4
- 229930192474 thiophene Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- OXHNLMTVIGZXSG-UHFFFAOYSA-N 1-Methylpyrrole Chemical compound CN1C=CC=C1 OXHNLMTVIGZXSG-UHFFFAOYSA-N 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- RSBQFKJVGZVGFM-UHFFFAOYSA-N 1,3-diaminopropan-2-one Chemical group NCC(=O)CN RSBQFKJVGZVGFM-UHFFFAOYSA-N 0.000 abstract 1
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- UJWQICAHCZVIRT-UHFFFAOYSA-N 2,7-dimethylpyrazolo[1,5-a]pyrimidine Chemical compound N1=CC=C(C)N2N=C(C)C=C21 UJWQICAHCZVIRT-UHFFFAOYSA-N 0.000 abstract 1
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 abstract 1
- QIMCTRHEMFULEC-UHFFFAOYSA-N 4,7-dimethylpyrazolo[5,1-c][1,2,4]triazine Chemical compound N1=NC=C(C)N2N=C(C)C=C21 QIMCTRHEMFULEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IWVSKNFJIVKXHH-UHFFFAOYSA-N pyrazine;pyrimidine Chemical compound C1=CN=CN=C1.C1=CN=CC=N1 IWVSKNFJIVKXHH-UHFFFAOYSA-N 0.000 abstract 1
- VJYJJHQEVLEOFL-UHFFFAOYSA-N thieno[3,2-b]thiophene Chemical compound S1C=CC2=C1C=CS2 VJYJJHQEVLEOFL-UHFFFAOYSA-N 0.000 abstract 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- Pyridine Compounds (AREA)
Abstract
Se proporciona inhibidores de proteasa de bis-aminometil-carbonilo, que comprenden un compuesto de la formula(I):R1 y R2 son independientemente H o alquiloC1-6,siempre y cuando R1 y R2 no sean ambos alquilo C1-6;formula(II)R3 se elige entre el grupoformado pr CH2CH(CH3)2, CH2CH2CH3, CH3CH=CH2 o CH2Ph;R4 se eligeentre el grupo formado por: alquilo C0-6; N-piperizina; N-tetrahidroisoquinoleína; alquilo C0-6 sustituido con fenilo, tiofeno, benzotiazol, 2-, 3-, 4-, 5-, 6-o 7-quinoleína, naftilo, 1-(7-nitro-2, 1, 3-benzoxadiazol-4-il)-L-prolilo, alquil(C0-6)pirazol, N-Cbz-2-(N,N-dimetilamino)etilglicil-, N-metilpirrol,benzoxazol, benciloxi, alcoxi C1-6; 2, 3, o 4-piridiniloxi; adamantilo, tieno [3,2-b]tiofeno; fenilo; tiofeno; benzotiofeno; benozofurano; benzotiazol; 2-, 3-,4-, 5-, 6- o 7-quinoleína; naftilo; y benzoxazol, cada uno de ellos independientemente sustituido con uno o más de los grupos alquilo C1-6, halogeno, nitro,ciano, hidroxi, alcoxi C1-6, trifluormetilo, carboxil, éster carboxi-alquilo (C1-6), alquil(C0-6)2N-alquilo C0-6, alquil (C0-6) 2N-alcoxi C0-6, N-(C0-C6)-N-piperizina, N-(N-alquil(C0-C6)N-piperidina)-4-alquil (C0-6)-amina, (alquil(C0-6) 2N-alquil(C0-6)-amina, N-morfolino-alquilo C0-6, N-morfolino-alquilo C0-6,N-morfolino-alcoxi C0-6, fenilo, tiofeno, benzotiazol, 2, 3, 4, 5, 6 o 7-quinoleína, naftilo, alquil(C0-6) pirazol, N-metil-pirrol, benzoxazol; benciloxisustituido con uno o más grupos alquilo (C1-6), halogeno, nitro, ciano, hidroxi, alcoxi (C1-6), trifluormetilo, carboxilo, éster carboxi alquilo (C1-6), fenilo, tiofeno, bentiazol, 2, 3, 4, 5 o 7 quinoleína, naftilo, alquil (C0-6) pirazol, N-metil-pirrol, y benzoxazol; y pirazina; pirimidina; 2,7-dimetilpirazolo[1,5a]pirimidina y 4,7 dimetilpirazolo[5,1-c][1,2,4]-triazina. R6 se elige entre el grupo formado por fenilo y fenilo sustituido con alquilo C0-6, N-piperidina,benzofurano; o 2,3 o 4 piridina; Q es formula (III)en la que R7 se elige entre el grupo formado por fenilo y fenilo sustituidocon alquilo (C0-C6),N-piperidina, benzofurano; o 2, 3 o 4 piridina; R8 se elige entre el grupo formado por H, CH2Ch(CH3)2, CH2CH2CH3 y CH2CH=CH2, CH2Ph, cuando R9 es H; o R8 y R9
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8655798P | 1998-05-21 | 1998-05-21 |
Publications (1)
Publication Number | Publication Date |
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AR018370A1 true AR018370A1 (es) | 2001-11-14 |
Family
ID=22199378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990102442A AR018370A1 (es) | 1998-05-21 | 1999-05-21 | Inhibidores de proteasas, composiciones farmaceuticas que lo comprenden, uso de los mismos para la manufactura de un medicamento |
Country Status (10)
Country | Link |
---|---|
US (1) | US6518267B1 (es) |
EP (1) | EP1067894A4 (es) |
JP (1) | JP2002515411A (es) |
AR (1) | AR018370A1 (es) |
AU (1) | AU4092799A (es) |
CA (1) | CA2332531A1 (es) |
CO (1) | CO5080801A1 (es) |
DZ (1) | DZ2796A1 (es) |
MA (1) | MA26631A1 (es) |
WO (1) | WO1999059526A2 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586466B2 (en) | 1995-10-30 | 2003-07-01 | Smithkline Beecham Corporation | Carbohydrazide-protease inhibitors |
CO5150165A1 (es) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
AU1474801A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
JP2003513972A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
CN1416346A (zh) | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
FR2832405B1 (fr) * | 2001-11-19 | 2004-12-10 | Sanofi Synthelabo | Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant |
US7282512B2 (en) | 2002-01-17 | 2007-10-16 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors |
MXPA04010441A (es) | 2002-04-23 | 2005-02-14 | Shionogi & Co | Derivado de pirazolo[1,5-a]pirimidina e inhibidor de nad(p)h oxidasa que contiene el mismo. |
JP2007503401A (ja) * | 2003-08-27 | 2007-02-22 | メルク フロスト カナダ リミテツド | カテプシン阻害剤 |
AR050559A1 (es) * | 2004-09-07 | 2006-11-01 | Smithkline Beecham Corp | Compuesto de diamina aciclica, composicion farmaceutica que lo comprende y su uso para la preparacion de dicha composicion |
WO2009128521A1 (ja) * | 2008-04-15 | 2009-10-22 | 帝人ファーマ株式会社 | システインプロテアーゼ阻害剤 |
CN104311408B (zh) * | 2014-09-12 | 2019-11-08 | 沈阳化工研究院有限公司 | 4,4’-二苯醚二甲酸的制备方法 |
CN111943818B (zh) * | 2020-09-16 | 2023-01-24 | 天津均凯农业科技有限公司 | 一种制备4,4′-双三氟甲基二苯醚的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ132798A3 (cs) * | 1995-10-30 | 1999-02-17 | Smithkline Beecham Corporation | Inhibitory proteázy |
MA26618A1 (fr) * | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
-
1999
- 1999-05-19 DZ DZ990096A patent/DZ2796A1/xx active
- 1999-05-19 MA MA25586A patent/MA26631A1/fr unknown
- 1999-05-20 CA CA002332531A patent/CA2332531A1/en not_active Abandoned
- 1999-05-20 AU AU40927/99A patent/AU4092799A/en not_active Abandoned
- 1999-05-20 WO PCT/US1999/011266 patent/WO1999059526A2/en not_active Application Discontinuation
- 1999-05-20 EP EP99924421A patent/EP1067894A4/en not_active Withdrawn
- 1999-05-20 US US09/700,828 patent/US6518267B1/en not_active Expired - Fee Related
- 1999-05-20 JP JP2000549192A patent/JP2002515411A/ja not_active Withdrawn
- 1999-05-20 CO CO99030929A patent/CO5080801A1/es unknown
- 1999-05-21 AR ARP990102442A patent/AR018370A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2332531A1 (en) | 1999-11-25 |
EP1067894A4 (en) | 2004-09-08 |
WO1999059526A3 (en) | 2000-01-20 |
EP1067894A2 (en) | 2001-01-17 |
JP2002515411A (ja) | 2002-05-28 |
AU4092799A (en) | 1999-12-06 |
WO1999059526A2 (en) | 1999-11-25 |
MA26631A1 (fr) | 2004-12-20 |
CO5080801A1 (es) | 2001-09-25 |
US6518267B1 (en) | 2003-02-11 |
DZ2796A1 (fr) | 2003-12-01 |
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