AR016125A1 - Analisis de nucleotidos en solucion utilizando un efecto de reduccion de la intensidad fluorescente - Google Patents

Analisis de nucleotidos en solucion utilizando un efecto de reduccion de la intensidad fluorescente

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Publication number
AR016125A1
AR016125A1 ARP980103211A ARP980103211A AR016125A1 AR 016125 A1 AR016125 A1 AR 016125A1 AR P980103211 A ARP980103211 A AR P980103211A AR P980103211 A ARP980103211 A AR P980103211A AR 016125 A1 AR016125 A1 AR 016125A1
Authority
AR
Argentina
Prior art keywords
nucleotides
probes
analysis
solution
reduction effect
Prior art date
Application number
ARP980103211A
Other languages
English (en)
Original Assignee
Lorne Park Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lorne Park Res Inc filed Critical Lorne Park Res Inc
Publication of AR016125A1 publication Critical patent/AR016125A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invencion brinda un método para secuenciar y analizar mediante ensayo, en forma rápida, economica y efectiva, nucleotidos en un medio líquido,utilizando fluorescencia inducida por láser de sondas antisentido, incluyendo sondas PNA. La intensidadf luorescente del medio resultante es inversamenteproporcional a la eficiencia de hibridizacion de las sondas con respecto a la secuencia blanco. El método es particularmente ventajoso debido a que norequiere la separacion de sondas no hibridizadasy complejos de hibridizacion antes de la deteccion. El método puede utilizarse para identificar regionesaccesibles en secuencia de nucleotidos plegados, para identificar el numero de pares sin coincidencia en un complejo de hibridizacion y paramapearg enomas.
ARP980103211A 1997-07-01 1998-07-01 Analisis de nucleotidos en solucion utilizando un efecto de reduccion de la intensidad fluorescente AR016125A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/886,280 US5846729A (en) 1997-02-27 1997-07-01 Assaying nucleotides in solution using a fluorescent intensity quenching effect

Publications (1)

Publication Number Publication Date
AR016125A1 true AR016125A1 (es) 2001-06-20

Family

ID=25388774

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103211A AR016125A1 (es) 1997-07-01 1998-07-01 Analisis de nucleotidos en solucion utilizando un efecto de reduccion de la intensidad fluorescente

Country Status (10)

Country Link
US (1) US5846729A (es)
EP (1) EP1002125A1 (es)
JP (1) JP2001510681A (es)
AR (1) AR016125A1 (es)
AU (1) AU730865B2 (es)
CA (1) CA2295333C (es)
IN (1) IN189178B (es)
TW (1) TWI235765B (es)
WO (1) WO1999001578A1 (es)
ZA (1) ZA985758B (es)

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Also Published As

Publication number Publication date
WO1999001578A1 (en) 1999-01-14
AU8030298A (en) 1999-01-25
CA2295333C (en) 2005-03-01
CA2295333A1 (en) 1999-01-14
US5846729A (en) 1998-12-08
ZA985758B (en) 1999-01-27
AU730865B2 (en) 2001-03-15
IN189178B (es) 2003-01-04
EP1002125A1 (en) 2000-05-24
JP2001510681A (ja) 2001-08-07
TWI235765B (en) 2005-07-11

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