AR014514A1 - Un polinucleotido aislado; un polipeptido aislado codificado por dicho polinucleotido; un vector de expresion que comprende dicho polinucleotido; unacelula transformada con dicho vector de expresion; una composicion farmaceutica y una vacuna que comprenden el polipeptido para el tratamiento de cance - Google Patents
Un polinucleotido aislado; un polipeptido aislado codificado por dicho polinucleotido; un vector de expresion que comprende dicho polinucleotido; unacelula transformada con dicho vector de expresion; una composicion farmaceutica y una vacuna que comprenden el polipeptido para el tratamiento de canceInfo
- Publication number
- AR014514A1 AR014514A1 ARP990100346A ARP990100346A AR014514A1 AR 014514 A1 AR014514 A1 AR 014514A1 AR P990100346 A ARP990100346 A AR P990100346A AR P990100346 A ARP990100346 A AR P990100346A AR 014514 A1 AR014514 A1 AR 014514A1
- Authority
- AR
- Argentina
- Prior art keywords
- polinucleotide
- isolated
- polypeptide
- expression vector
- polynucleotides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Polinucleotidos aislados que codifican polipéptidos de tumor de pulmon. Estos polinucleotidos comprenden una secuencia de nucleotidos seleccionada delgrupo consistente en: (a) secuencias provistas en SEQ. ID. NO.: 1-11, 19, 22- 25, 27-31, 51, 53, 55, 63, 70, 72, 79, 80, 86, 87, 89, 90, 102-107, 109, 139,143-149, 151-154, y 156-158; (b) secuencias complementarias para una secuencia provista en SEQ. ID. NO.: 1-11, 19, 22-25, 27-31, 51, 53, 55, 63, 70, 72, 79,80, 86, 89, 90, 102-107, 109, 139, 143-149, 151-154, y 156-158; y (c) variantes de las secuencias de (a) y (b). Los polipéptidos aislados comprenden al menosuna porcion inmunogénica de una proteína de tumor pulmonar, o de una variante de ella. Vectores de expresion que comprendenlos polinucleotidos; célulashuéspedes transformadas o transinfectadas con estos vectores de expresion. Las proteínas de fusion comprenden un primer y un segundo polipéptido, o bien, elpolipéptido y un antígeno de tumor de pulmon conocido. Las composiciones farmacéuticas comprenden uno o más de los polipéptidos codificados por unpolinucleotido que comprende una secuencia seleccionada del grupo que consiste de (a) secuencias provistas en SEQ. ID. NO.: 1 a 181; (b) complementos de lassecuencias provistas en SEQ. ID. NO.: 1 a 181; (c) variantes de las secuencias de (a) y (b); proteínas de fusion, o polinucleotidos, y un vehículofisiologicamente aceptable. Las vacunas comprenden uno o más de los polipéptidos, proteínas de fusion, o polinucleotidos, combinados con unmejorador de respuesta inmune. Los métodos para inhibir el desarrollo de cáncer de pulmon en un paciente consisten en administrar a un paciente una cantidadeficaz de al menos una de las composiciones farmacéuticas y/o vacunas mencionadas. Métodos para detectar cáncer de pulmon en un paciente consisten en
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1502298A | 1998-01-28 | 1998-01-28 | |
US1502998A | 1998-01-28 | 1998-01-28 | |
US4083198A | 1998-03-18 | 1998-03-18 | |
US4082898A | 1998-03-18 | 1998-03-18 | |
US12219198A | 1998-07-23 | 1998-07-23 | |
US12219298A | 1998-07-23 | 1998-07-23 | |
US21924598A | 1998-12-22 | 1998-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR014514A1 true AR014514A1 (es) | 2001-02-28 |
Family
ID=27567530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990100346A AR014514A1 (es) | 1998-01-28 | 1999-01-28 | Un polinucleotido aislado; un polipeptido aislado codificado por dicho polinucleotido; un vector de expresion que comprende dicho polinucleotido; unacelula transformada con dicho vector de expresion; una composicion farmaceutica y una vacuna que comprenden el polipeptido para el tratamiento de cance |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1051489A2 (es) |
JP (1) | JP2002516659A (es) |
KR (1) | KR20010034436A (es) |
CN (1) | CN1292029A (es) |
AR (1) | AR014514A1 (es) |
AU (1) | AU2344399A (es) |
BR (1) | BR9907259A (es) |
CA (1) | CA2319117A1 (es) |
ID (1) | ID27813A (es) |
IL (1) | IL137417A0 (es) |
NO (1) | NO20003853L (es) |
WO (1) | WO1999038973A2 (es) |
ZA (1) | ZA99693B (es) |
Families Citing this family (66)
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US6518256B1 (en) | 1998-03-18 | 2003-02-11 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US6737514B1 (en) | 1998-12-22 | 2004-05-18 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6531315B1 (en) | 1998-03-18 | 2003-03-11 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6960570B2 (en) | 1998-03-18 | 2005-11-01 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US7049063B2 (en) | 1998-03-18 | 2006-05-23 | Corixa Corporation | Methods for diagnosis of lung cancer |
US7258860B2 (en) | 1998-03-18 | 2007-08-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6660838B1 (en) | 1998-03-18 | 2003-12-09 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US6426072B1 (en) | 2000-08-02 | 2002-07-30 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6706262B1 (en) | 1998-03-18 | 2004-03-16 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US6821518B1 (en) | 1998-03-18 | 2004-11-23 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US6696247B2 (en) | 1998-03-18 | 2004-02-24 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
US6312695B1 (en) | 1998-03-18 | 2001-11-06 | Corixa Corporation | Compounds and methods for therapy of lung cancer |
US6482597B1 (en) | 1999-12-17 | 2002-11-19 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
EP1526383A3 (en) * | 1998-08-31 | 2005-11-16 | Pfizer Products Inc. | Diarylsulfonylurea binding proteins |
EP0987552A3 (en) * | 1998-08-31 | 2000-06-07 | Pfizer Products Inc. | Diarylsulfonylurea binding proteins |
WO2000026241A2 (en) * | 1998-10-28 | 2000-05-11 | Rigel Pharmaceuticals, Inc. | Novel compositions and methods of screening for t-cell and b-cell activation modulators |
US6709855B1 (en) | 1998-12-18 | 2004-03-23 | Scios, Inc. | Methods for detection and use of differentially expressed genes in disease states |
WO2000035473A2 (en) * | 1998-12-18 | 2000-06-22 | Scios Inc. | Methods for detection and use of differentially expressed genes in disease states |
WO2000046370A1 (en) * | 1999-02-04 | 2000-08-10 | Board Of Trustees Of The University Of Illinois | P37ing1 compositions and methods of use |
WO2000048625A2 (en) | 1999-02-19 | 2000-08-24 | Zymogenetics, Inc. | Inhibitors for use in hemostasis and immune function |
US6544946B1 (en) | 1999-02-19 | 2003-04-08 | Zymogenetics, Inc. | Inhibitors for use in hemostasis and immune function |
ATE399793T1 (de) * | 1999-04-02 | 2008-07-15 | Corixa Corp | Verbindungen und verfahren für therapie und diagnose von lungenkrebs |
US6444425B1 (en) | 1999-04-02 | 2002-09-03 | Corixa Corporation | Compounds for therapy and diagnosis of lung cancer and methods for their use |
EP1187915A2 (en) * | 1999-04-02 | 2002-03-20 | Corixa Corporation | Compounds for therapy and diagnosis of lung cancer and methods for their use |
US6759508B2 (en) | 2000-09-01 | 2004-07-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6914132B1 (en) | 1999-06-30 | 2005-07-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
JP2004500029A (ja) | 1999-06-30 | 2004-01-08 | コリクサ コーポレイション | 肺癌の治療および診断のための組成物および方法 |
US6667154B1 (en) | 1999-06-30 | 2003-12-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6686447B1 (en) | 1999-06-30 | 2004-02-03 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US20030211510A1 (en) | 1999-06-30 | 2003-11-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US20030125245A1 (en) | 1999-06-30 | 2003-07-03 | Tongtong Wang | Compositions and methods for therapy and diagnosis of lung cancer |
US6858204B2 (en) | 1999-06-30 | 2005-02-22 | Corxia Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6746846B1 (en) | 1999-06-30 | 2004-06-08 | Corixa Corporation | Methods for diagnosing lung cancer |
US6509448B2 (en) | 1999-06-30 | 2003-01-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6504010B1 (en) | 1999-06-30 | 2003-01-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
CA2309313A1 (en) * | 1999-08-05 | 2001-02-05 | Board Of Trustees Of The University Of Arkansas | Stimulation of the immune response by human dendritic cell manipulation |
WO2001021653A2 (en) * | 1999-09-23 | 2001-03-29 | Corixa Corporation | Ovarian tumor antigen and methods of use therefor |
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AU2001253388A1 (en) * | 2000-04-14 | 2001-10-30 | Incyte Genomics, Inc. | Molecules associated with human reproduction |
US20020099012A1 (en) * | 2000-06-29 | 2002-07-25 | Tongtong Wang | Compositions and methods for the therapy and diagnosis of lung cancer |
EP1343886A2 (en) * | 2000-07-11 | 2003-09-17 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
AU2001270638A1 (en) * | 2000-07-19 | 2002-01-30 | Bayer Aktiengesellschaft | Regulation of human airway trypsin protease-like enzyme |
TWI317380B (en) * | 2000-08-28 | 2009-11-21 | Teijin Ltd | Airway-specific trypsin-like enzymes and method of using the same |
US7348406B2 (en) | 2001-01-16 | 2008-03-25 | Serono Genetics Institute S.A. | Metabolic gene polynucleotides and polypeptides and uses thereof |
US7226994B2 (en) | 2001-01-18 | 2007-06-05 | Cambridge University Technical Services Limited | Cell surface expressed marker of pluripotency |
GB0101300D0 (en) * | 2001-01-18 | 2001-02-28 | Univ Cambridge Tech | Primordial germ cell genes |
EP1402031A2 (en) | 2001-06-21 | 2004-03-31 | Isis Innovation Limited | Atopy |
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MX2007006441A (es) * | 2004-11-30 | 2007-08-14 | Johnson & Johnson | Prognosis de cancer de pulmon. |
CA2626238C (en) | 2005-10-17 | 2015-10-06 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
US9265816B2 (en) | 2006-04-10 | 2016-02-23 | Sloan Kettering Institute For Cancer Research | Immunogenic WT-1 peptides and methods of use thereof |
EP2423333A1 (en) * | 2006-08-25 | 2012-02-29 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
WO2010030167A2 (en) * | 2008-09-12 | 2010-03-18 | Cancer Research Initiative Foundation | Method of detection and diagnosis of oral and nasopharyngeal cancers |
CN101891802B (zh) * | 2009-08-11 | 2011-11-16 | 武汉凯泰新生物技术有限公司 | 治疗或预防癌症的多肽或衍生产品及其应用 |
CN101921313B (zh) * | 2010-04-07 | 2012-02-29 | 武汉凯泰新生物技术有限公司 | 治疗或预防癌症的多肽或其衍生产品及应用 |
GB201104286D0 (en) * | 2011-03-15 | 2011-04-27 | Randox Lab Ltd | Glutathione S-transferase omega 1 wild type specific antibody |
CN103958679A (zh) * | 2011-09-09 | 2014-07-30 | 转基因股份有限公司 | 变异型α-辅肌动蛋白-4的抗体 |
US20150104413A1 (en) | 2012-01-13 | 2015-04-16 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and methods of use thereof |
US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
EP3769782A1 (en) | 2013-01-15 | 2021-01-27 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and methods of use thereof |
EP3440101B1 (en) * | 2016-04-04 | 2021-10-06 | Indi Molecular, Inc. | Cd8-specific capture agents, compositions, and methods of using and making |
CN110669104B (zh) * | 2019-10-30 | 2021-11-05 | 上海交通大学 | 一组来源于人外周血单核细胞的标志物及其应用 |
CN112500467B (zh) * | 2020-12-14 | 2022-05-24 | 上海交通大学 | 一种生物活性肽rrecpsdecgagvf及其制备方法和应用 |
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US5589579A (en) * | 1994-07-19 | 1996-12-31 | Cytoclonal Pharmaceutics, Inc. | Gene sequence and probe for a marker of non-small cell lung carinoma |
US5633161A (en) * | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
-
1999
- 1999-01-20 ID IDW20001646A patent/ID27813A/id unknown
- 1999-01-26 JP JP2000529432A patent/JP2002516659A/ja not_active Withdrawn
- 1999-01-26 CN CN99803446A patent/CN1292029A/zh active Pending
- 1999-01-26 KR KR1020007008209A patent/KR20010034436A/ko not_active Application Discontinuation
- 1999-01-26 CA CA002319117A patent/CA2319117A1/en not_active Abandoned
- 1999-01-26 IL IL13741799A patent/IL137417A0/xx unknown
- 1999-01-26 BR BR9907259-9A patent/BR9907259A/pt not_active Application Discontinuation
- 1999-01-26 AU AU23443/99A patent/AU2344399A/en not_active Abandoned
- 1999-01-26 WO PCT/US1999/001642 patent/WO1999038973A2/en not_active Application Discontinuation
- 1999-01-26 EP EP99903417A patent/EP1051489A2/en not_active Withdrawn
- 1999-01-28 ZA ZA9900693A patent/ZA99693B/xx unknown
- 1999-01-28 AR ARP990100346A patent/AR014514A1/es unknown
-
2000
- 2000-07-27 NO NO20003853A patent/NO20003853L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CN1292029A (zh) | 2001-04-18 |
ID27813A (id) | 2001-04-26 |
WO1999038973A3 (en) | 1999-12-09 |
NO20003853D0 (no) | 2000-07-27 |
AU2344399A (en) | 1999-08-16 |
KR20010034436A (ko) | 2001-04-25 |
IL137417A0 (en) | 2001-07-24 |
JP2002516659A (ja) | 2002-06-11 |
BR9907259A (pt) | 2002-01-22 |
NO20003853L (no) | 2000-09-27 |
EP1051489A2 (en) | 2000-11-15 |
ZA99693B (en) | 1999-10-21 |
CA2319117A1 (en) | 1999-08-05 |
WO1999038973A2 (en) | 1999-08-05 |
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