AR013372A1 - Compuestos de naftamidina inhibidores de uroquinasa, composiciones farmaceuticas que los contienen, y uso de dichos compuestos para prepararmedicamentos - Google Patents

Compuestos de naftamidina inhibidores de uroquinasa, composiciones farmaceuticas que los contienen, y uso de dichos compuestos para prepararmedicamentos

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Publication number
AR013372A1
AR013372A1 ARP980103690A ARP980103690A AR013372A1 AR 013372 A1 AR013372 A1 AR 013372A1 AR P980103690 A ARP980103690 A AR P980103690A AR P980103690 A ARP980103690 A AR P980103690A AR 013372 A1 AR013372 A1 AR 013372A1
Authority
AR
Argentina
Prior art keywords
compounds
group
hydrogen
naftamidine
pharmaceutical compositions
Prior art date
Application number
ARP980103690A
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English (en)
Original Assignee
Abbott Lab
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Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR013372A1 publication Critical patent/AR013372A1/es

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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Compuestos de naftamidina que tienen la formula (I), donde Z está seleccionado del grupo que consiste en (1) nitrogeno; (2) metina; y (3)metinasubstituida con -NR1R2; A está seleccionado del grupo que consiste en (1) hidrogeno y (2) -L(A)R(A); B está seleccionado del grupo que consiste e: (1)hidrogeno y (2) -L(B)R(B); y C está seleccionado del grupo que consiste en (1) hidrogeno y (2) -L(C)R(C); con la condicion de que por lo menos uno de A,B o C es distinto de hidrogeno; ycon la condicion de que cuando A es distinto de hidrogeno, por lo menos uno de B o C es distinto de hidrogeno, donde A, B yC, L(A), L(B) y L(C) están independientemente seleccionados del grupo que consiste en: (1) un enlace covalente; (2)-(CH2)m-; (3) -NR1-; (4) -NR2C(X)NR3-;(5) -C(X)-; (6) -NR2C(X)-; (7) -C(X)NR2-; (8) -CH=CH-; (9) -C:::C-; (10) -O-; (11) -S(O)t-; (12) -C:::C(CH2)nNR2C(X)-; (13) -C(X)NR2(CH2)nC:::C-; (14)-(CH2)nNSO2-; (15) -NR2SO2(CH2)nC:::C-; (16) -C:::C(CH2)nNR2SO2NR3-; (17)-NR2SO2NR3 (CH2)nC:::C-; (18) -SO2NR2-; (19) -NR2SO2-; (2) -NR2SO2NR3-; (21) -N=N-; (22)-C(X)N(OR2)-; (23)-N(OR2)C(X)-; (24) -HC=CH(CH2)nNR2C(X)-; (25)-(CH2)nNR2C(X)CH =CH-; (26)-CH=CH(CH2)nNSO2-; (27)-NR2SO2(CH2)nCH=CH-; (28)-(CH2)nNR2SO2NR3-;(29) -NR2SO2NR3(CH2)nCH=CH-; (30)-NR2C(O)O-; (31)-OC(O)NR2-; (32)-CH=NO-; (33) -ON=CH- y (34) formula (II), donde W se selecciona del grupo que consiste en:(a) -O-; (b)-S-; (c) -NR1- y (d) -(CH2)m-; donde cada grupo funcional se describecon su extremo a mano derecha que es el extremo que está adheridoal anillo naftilo o quinolilo, y su extremo a mano izquierda es el extremo que está adherido a R(A), R(B) o (R(C); R(A), R(B) y R(C) están independientementeseleccionados del grupo que consiste en: (1) arilo; (2) arilalcoxi, donde el grupo alquileno es de 1 a 6 átomos de carbono; (3) alquilo de 1 a 10 átomos
ARP980103690A 1997-07-25 1998-07-27 Compuestos de naftamidina inhibidores de uroquinasa, composiciones farmaceuticas que los contienen, y uso de dichos compuestos para prepararmedicamentos AR013372A1 (es)

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