AR013372A1 - Compuestos de naftamidina inhibidores de uroquinasa, composiciones farmaceuticas que los contienen, y uso de dichos compuestos para prepararmedicamentos - Google Patents
Compuestos de naftamidina inhibidores de uroquinasa, composiciones farmaceuticas que los contienen, y uso de dichos compuestos para prepararmedicamentosInfo
- Publication number
- AR013372A1 AR013372A1 ARP980103690A ARP980103690A AR013372A1 AR 013372 A1 AR013372 A1 AR 013372A1 AR P980103690 A ARP980103690 A AR P980103690A AR P980103690 A ARP980103690 A AR P980103690A AR 013372 A1 AR013372 A1 AR 013372A1
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- Prior art keywords
- compounds
- group
- hydrogen
- naftamidine
- pharmaceutical compositions
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/66—Y being a hetero atom
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/58—Amidines
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract
Compuestos de naftamidina que tienen la formula (I), donde Z está seleccionado del grupo que consiste en (1) nitrogeno; (2) metina; y (3)metinasubstituida con -NR1R2; A está seleccionado del grupo que consiste en (1) hidrogeno y (2) -L(A)R(A); B está seleccionado del grupo que consiste e: (1)hidrogeno y (2) -L(B)R(B); y C está seleccionado del grupo que consiste en (1) hidrogeno y (2) -L(C)R(C); con la condicion de que por lo menos uno de A,B o C es distinto de hidrogeno; ycon la condicion de que cuando A es distinto de hidrogeno, por lo menos uno de B o C es distinto de hidrogeno, donde A, B yC, L(A), L(B) y L(C) están independientemente seleccionados del grupo que consiste en: (1) un enlace covalente; (2)-(CH2)m-; (3) -NR1-; (4) -NR2C(X)NR3-;(5) -C(X)-; (6) -NR2C(X)-; (7) -C(X)NR2-; (8) -CH=CH-; (9) -C:::C-; (10) -O-; (11) -S(O)t-; (12) -C:::C(CH2)nNR2C(X)-; (13) -C(X)NR2(CH2)nC:::C-; (14)-(CH2)nNSO2-; (15) -NR2SO2(CH2)nC:::C-; (16) -C:::C(CH2)nNR2SO2NR3-; (17)-NR2SO2NR3 (CH2)nC:::C-; (18) -SO2NR2-; (19) -NR2SO2-; (2) -NR2SO2NR3-; (21) -N=N-; (22)-C(X)N(OR2)-; (23)-N(OR2)C(X)-; (24) -HC=CH(CH2)nNR2C(X)-; (25)-(CH2)nNR2C(X)CH =CH-; (26)-CH=CH(CH2)nNSO2-; (27)-NR2SO2(CH2)nCH=CH-; (28)-(CH2)nNR2SO2NR3-;(29) -NR2SO2NR3(CH2)nCH=CH-; (30)-NR2C(O)O-; (31)-OC(O)NR2-; (32)-CH=NO-; (33) -ON=CH- y (34) formula (II), donde W se selecciona del grupo que consiste en:(a) -O-; (b)-S-; (c) -NR1- y (d) -(CH2)m-; donde cada grupo funcional se describecon su extremo a mano derecha que es el extremo que está adheridoal anillo naftilo o quinolilo, y su extremo a mano izquierda es el extremo que está adherido a R(A), R(B) o (R(C); R(A), R(B) y R(C) están independientementeseleccionados del grupo que consiste en: (1) arilo; (2) arilalcoxi, donde el grupo alquileno es de 1 a 6 átomos de carbono; (3) alquilo de 1 a 10 átomos
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US90104097A | 1997-07-25 | 1997-07-25 |
Publications (1)
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AR013372A1 true AR013372A1 (es) | 2000-12-27 |
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ID=25413502
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Application Number | Title | Priority Date | Filing Date |
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ARP980103690A AR013372A1 (es) | 1997-07-25 | 1998-07-27 | Compuestos de naftamidina inhibidores de uroquinasa, composiciones farmaceuticas que los contienen, y uso de dichos compuestos para prepararmedicamentos |
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EP (1) | EP1000018A2 (es) |
JP (1) | JP2002512636A (es) |
KR (1) | KR20010014369A (es) |
CN (1) | CN1265645A (es) |
AR (1) | AR013372A1 (es) |
AU (1) | AU8587498A (es) |
BG (1) | BG103981A (es) |
BR (1) | BR9811099A (es) |
CA (1) | CA2294300A1 (es) |
HU (1) | HUP0100353A3 (es) |
IL (1) | IL133368A0 (es) |
NO (1) | NO996578L (es) |
PL (1) | PL339429A1 (es) |
SK (1) | SK174899A3 (es) |
WO (1) | WO1999005096A2 (es) |
ZA (1) | ZA986594B (es) |
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WO2000005214A2 (en) * | 1998-07-24 | 2000-02-03 | Pfizer Inc. | Isoquinolines as urokinase inhibitors |
US6504031B1 (en) | 1998-08-06 | 2003-01-07 | Milan Bruncko | Naphthamidine urokinase inhibitors |
GB9914486D0 (en) | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
JP4815083B2 (ja) * | 1999-08-31 | 2011-11-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 複素環化合物およびそれの使用方法 |
US20030232789A1 (en) * | 1999-12-15 | 2003-12-18 | Allen Darin Arthur | Salicylamides as serine protease and factor xa inhibitors |
US6495562B1 (en) | 2000-04-25 | 2002-12-17 | Abbott Laboratories | Naphthamidine urokinase inhibitors |
MXPA02010593A (es) * | 2000-04-25 | 2003-05-14 | Abbott Lab | Inhibidores de uroquinasa de naftamidina. |
DE10029014A1 (de) | 2000-06-15 | 2001-12-20 | Univ Schiller Jena | Urokinase-Hemmstoffe |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
US6949567B2 (en) | 2001-02-26 | 2005-09-27 | 4Sc Ag | Compounds for the treatment of protozoal diseases |
JP4898091B2 (ja) | 2002-03-11 | 2012-03-14 | ザ メディシンズ カンパニー (ライプツィヒ) ゲーエムベーハー | ウロキナーゼの阻害剤、それらの製造および使用 |
US7053112B2 (en) * | 2002-09-24 | 2006-05-30 | Schering Aktiengesellschaft | Imidazolidinedione analogs useful as anticoagulants and antithrombotics |
DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
DE10342108A1 (de) | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
US7545495B2 (en) | 2004-04-27 | 2009-06-09 | Abbott Laboratories | Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample |
NZ587551A (en) | 2004-06-24 | 2012-01-12 | Vertex Pharma | 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol |
US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
DE102004045720A1 (de) * | 2004-09-21 | 2006-03-23 | Wilex Ag | Stabile Dosierungsform von Phenylalanin-Derivaten |
WO2006136419A2 (en) | 2005-06-24 | 2006-12-28 | Wilex Ag | Use of urokinase inhibitors for the treatment and/or prevention of neuropathological diseases |
US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
SI3219705T1 (sl) | 2005-12-28 | 2020-08-31 | Vertex Pharmaceuticals Incorporated | Farmacevtski sestavki amorfne oblike N-(2,4-bis(1,1-dimetiletil)-5- hidroksifenil)-1,4-dihidro-4-oksokinolin-3-karboksamid |
DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
RU2543714C2 (ru) | 2009-03-20 | 2015-03-10 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения модуляторов регулятора трансмембранной проводимости кистозного фиброза |
JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
BR112014021090B1 (pt) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma |
RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
GB201617758D0 (en) | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
JP2022552019A (ja) | 2019-10-18 | 2022-12-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 病的血管障害の治療のための作用物質としての3-フェニルスルホニル-キノリン誘導体 |
WO2023165874A1 (en) * | 2022-03-01 | 2023-09-07 | Syngenta Crop Protection Ag | Pyrimidinyl-oxy-quinoline based herbicidal compounds |
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ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
US5340833A (en) * | 1992-05-01 | 1994-08-23 | Eisai Co., Ltd. | Urokinase inhibitors |
JP3457694B2 (ja) * | 1993-02-04 | 2003-10-20 | 第一製薬株式会社 | インフルエンザ感染予防・治療薬 |
WO1996016940A1 (fr) * | 1994-12-02 | 1996-06-06 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau derive d'amidinonaphtyle ou sel de celui-ci |
AU735144B2 (en) * | 1997-07-23 | 2001-07-05 | Yamanouchi Pharmaceutical Co., Ltd. | Novel hexahydro-1,4-diazepine derivatives or their salts |
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1998
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- 1998-07-24 CA CA002294300A patent/CA2294300A1/en not_active Abandoned
- 1998-07-24 JP JP51012199A patent/JP2002512636A/ja active Pending
- 1998-07-24 HU HU0100353A patent/HUP0100353A3/hu unknown
- 1998-07-24 SK SK1748-99A patent/SK174899A3/sk unknown
- 1998-07-24 IL IL13336898A patent/IL133368A0/xx unknown
- 1998-07-24 CN CN98806826A patent/CN1265645A/zh active Pending
- 1998-07-24 EP EP98937082A patent/EP1000018A2/en not_active Withdrawn
- 1998-07-24 WO PCT/US1998/015386 patent/WO1999005096A2/en not_active Application Discontinuation
- 1998-07-24 BR BR9811099-3A patent/BR9811099A/pt not_active Application Discontinuation
- 1998-07-24 KR KR1019997012528A patent/KR20010014369A/ko not_active Application Discontinuation
- 1998-07-24 PL PL98339429A patent/PL339429A1/xx unknown
- 1998-07-24 AU AU85874/98A patent/AU8587498A/en not_active Abandoned
- 1998-07-27 AR ARP980103690A patent/AR013372A1/es unknown
-
1999
- 1999-12-10 BG BG103981A patent/BG103981A/bg unknown
- 1999-12-30 NO NO996578A patent/NO996578L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1265645A (zh) | 2000-09-06 |
NO996578L (no) | 2000-01-25 |
ZA986594B (en) | 1999-01-27 |
IL133368A0 (en) | 2001-04-30 |
EP1000018A2 (en) | 2000-05-17 |
WO1999005096A2 (en) | 1999-02-04 |
AU8587498A (en) | 1999-02-16 |
SK174899A3 (en) | 2000-06-12 |
CA2294300A1 (en) | 1999-02-04 |
WO1999005096A3 (en) | 1999-06-03 |
HUP0100353A3 (en) | 2001-11-28 |
NO996578D0 (no) | 1999-12-30 |
PL339429A1 (en) | 2000-12-18 |
JP2002512636A (ja) | 2002-04-23 |
BG103981A (bg) | 2000-11-30 |
KR20010014369A (ko) | 2001-02-26 |
BR9811099A (pt) | 2002-05-14 |
HUP0100353A2 (hu) | 2001-05-28 |
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