AR011167A1 - Proceso para la preparacion de derivados de acido 4h-4-oxo-quinolizina-3- carboxilico - Google Patents
Proceso para la preparacion de derivados de acido 4h-4-oxo-quinolizina-3- carboxilicoInfo
- Publication number
- AR011167A1 AR011167A1 ARP980100840A ARP980100840A AR011167A1 AR 011167 A1 AR011167 A1 AR 011167A1 AR P980100840 A ARP980100840 A AR P980100840A AR P980100840 A ARP980100840 A AR P980100840A AR 011167 A1 AR011167 A1 AR 011167A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxo
- preparation
- alkyl
- group
- quinolizina
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un proceso para la preparacion de un compuesto que tiene la formula (I) en donde, R1 es seleccionado del grupo que consiste de C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C3-C6-cicloalquilo, fenilo, fluorofenilo, difluorofenilo,ni trofenilo, dinitrofenilo, y fluoropiridilo; R2 es C1-C3-alquilo, o ciclopropilo; R3 es cloro, bromo, iodo, metilsulfonato, trifluorometilsulfonato, o toluensulfonato; R4 es fluoro, cloro, bromo, oiodo y R5 es C1-C6-alquilo; a partirde u na amina mediante expansion de cadena y cierre de anillo, seguido por derivatizacion adicional, tratamientocon un compuesto 3-alcoxil-acriloilo, otro cierre de anillo, y conversion de un grupo hidroxilo a un grupo de salida. Derivadosde ácid o 4H-4-oxo-quinolizina-3-carboxílico, que tienen uso como intermedios en la preparacion de agentes antibacteriales de ácido 4H-4-oxo-quinolizina-3-carboxílico (también conocidoscomo antibioticos de piridona).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/806,806 US5693813A (en) | 1997-02-26 | 1997-02-26 | Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011167A1 true AR011167A1 (es) | 2000-08-02 |
Family
ID=25194886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100840A AR011167A1 (es) | 1997-02-26 | 1998-02-25 | Proceso para la preparacion de derivados de acido 4h-4-oxo-quinolizina-3- carboxilico |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5693813A (es) |
| EP (1) | EP0971919B1 (es) |
| JP (1) | JP2001513104A (es) |
| KR (1) | KR20000075700A (es) |
| CN (1) | CN1248256A (es) |
| AR (1) | AR011167A1 (es) |
| AT (1) | ATE207920T1 (es) |
| AU (1) | AU724353B2 (es) |
| BG (1) | BG103737A (es) |
| BR (1) | BR9807726A (es) |
| CA (1) | CA2281734A1 (es) |
| CO (1) | CO4920239A1 (es) |
| CZ (1) | CZ290252B6 (es) |
| DE (1) | DE69802274T2 (es) |
| DK (1) | DK0971919T3 (es) |
| ES (1) | ES2168740T3 (es) |
| HU (1) | HUP0001323A3 (es) |
| IL (1) | IL131050A0 (es) |
| NO (1) | NO994108L (es) |
| NZ (1) | NZ336876A (es) |
| PL (1) | PL335373A1 (es) |
| PT (1) | PT971919E (es) |
| SK (1) | SK115299A3 (es) |
| TR (1) | TR199901956T2 (es) |
| TW (1) | TW444017B (es) |
| WO (1) | WO1998038191A1 (es) |
| ZA (1) | ZA98836B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| CN106432222A (zh) * | 2016-09-19 | 2017-02-22 | 丹诺医药(苏州）有限公司 | 8‑氯‑1‑环丙基‑7‑氟‑9‑甲基‑4‑氧‑4‑氢‑喹嗪‑3‑羧酸酯及其制备方法 |
| CN106543170B (zh) * | 2016-10-27 | 2018-02-23 | 丹诺医药(苏州）有限公司 | 8‑氯‑1‑环丙基‑7‑氟‑9‑甲基‑4‑氧‑4‑氢‑喹嗪‑3‑羧酸酯及其合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726182A (en) * | 1990-05-02 | 1998-03-10 | Abbott Laboratories | Quinolizinone type compounds |
| IE911472A1 (en) * | 1990-05-02 | 1991-11-06 | Abbott Lab | Quinolizinone type compounds |
| ATE217309T1 (de) * | 1993-10-14 | 2002-05-15 | Abbott Lab | Verbindungen des chinolizinon-typs |
| IL122296A0 (en) * | 1995-06-06 | 1998-04-05 | Abbott Lab | Quinolizinone type compounds |
-
1997
- 1997-02-26 US US08/806,806 patent/US5693813A/en not_active Expired - Fee Related
-
1998
- 1998-02-02 ZA ZA98836A patent/ZA98836B/xx unknown
- 1998-02-06 TR TR1999/01956T patent/TR199901956T2/xx unknown
- 1998-02-06 WO PCT/US1998/002327 patent/WO1998038191A1/en not_active Application Discontinuation
- 1998-02-06 AU AU62718/98A patent/AU724353B2/en not_active Ceased
- 1998-02-06 PL PL98335373A patent/PL335373A1/xx unknown
- 1998-02-06 DK DK98904979T patent/DK0971919T3/da active
- 1998-02-06 DE DE69802274T patent/DE69802274T2/de not_active Expired - Fee Related
- 1998-02-06 KR KR1019997007767A patent/KR20000075700A/ko not_active Application Discontinuation
- 1998-02-06 CA CA002281734A patent/CA2281734A1/en not_active Abandoned
- 1998-02-06 JP JP53766398A patent/JP2001513104A/ja active Pending
- 1998-02-06 CZ CZ19992881A patent/CZ290252B6/cs not_active IP Right Cessation
- 1998-02-06 EP EP98904979A patent/EP0971919B1/en not_active Expired - Lifetime
- 1998-02-06 NZ NZ336876A patent/NZ336876A/xx unknown
- 1998-02-06 AT AT98904979T patent/ATE207920T1/de not_active IP Right Cessation
- 1998-02-06 IL IL13105098A patent/IL131050A0/xx unknown
- 1998-02-06 CN CN98802785A patent/CN1248256A/zh active Pending
- 1998-02-06 BR BR9807726-0A patent/BR9807726A/pt not_active IP Right Cessation
- 1998-02-06 PT PT98904979T patent/PT971919E/pt unknown
- 1998-02-06 HU HU0001323A patent/HUP0001323A3/hu unknown
- 1998-02-06 SK SK1152-99A patent/SK115299A3/sk unknown
- 1998-02-06 ES ES98904979T patent/ES2168740T3/es not_active Expired - Lifetime
- 1998-02-16 TW TW087102119A patent/TW444017B/zh not_active IP Right Cessation
- 1998-02-24 CO CO98009918A patent/CO4920239A1/es unknown
- 1998-02-25 AR ARP980100840A patent/AR011167A1/es unknown
-
1999
- 1999-08-25 NO NO994108A patent/NO994108L/no not_active Application Discontinuation
- 1999-09-16 BG BG103737A patent/BG103737A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6271898A (en) | 1998-09-18 |
| BG103737A (en) | 2000-06-30 |
| KR20000075700A (ko) | 2000-12-26 |
| AU724353B2 (en) | 2000-09-21 |
| HUP0001323A2 (hu) | 2000-10-28 |
| WO1998038191A1 (en) | 1998-09-03 |
| BR9807726A (pt) | 2000-02-15 |
| DE69802274T2 (de) | 2002-07-18 |
| US5693813A (en) | 1997-12-02 |
| TR199901956T2 (xx) | 1999-10-21 |
| PT971919E (pt) | 2002-04-29 |
| ES2168740T3 (es) | 2002-06-16 |
| ZA98836B (en) | 1998-08-05 |
| NZ336876A (en) | 2000-12-22 |
| CA2281734A1 (en) | 1998-09-03 |
| SK115299A3 (en) | 2000-01-18 |
| EP0971919B1 (en) | 2001-10-31 |
| HUP0001323A3 (en) | 2001-01-29 |
| NO994108D0 (no) | 1999-08-25 |
| JP2001513104A (ja) | 2001-08-28 |
| IL131050A0 (en) | 2001-01-28 |
| PL335373A1 (en) | 2000-04-25 |
| TW444017B (en) | 2001-07-01 |
| CO4920239A1 (es) | 2000-05-29 |
| DE69802274D1 (de) | 2001-12-06 |
| CZ288199A3 (cs) | 1999-11-17 |
| DK0971919T3 (da) | 2002-01-28 |
| CZ290252B6 (cs) | 2002-06-12 |
| EP0971919A1 (en) | 2000-01-19 |
| ATE207920T1 (de) | 2001-11-15 |
| CN1248256A (zh) | 2000-03-22 |
| NO994108L (no) | 1999-10-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |