AR009892A1 - Aplicacion de compuestos de imidazolidin-2,4-diona sustituidos, como medicamentos para el tratamiento del dolor - Google Patents

Aplicacion de compuestos de imidazolidin-2,4-diona sustituidos, como medicamentos para el tratamiento del dolor

Info

Publication number
AR009892A1
AR009892A1 ARP980103559A ARP980103559A AR009892A1 AR 009892 A1 AR009892 A1 AR 009892A1 AR P980103559 A ARP980103559 A AR P980103559A AR P980103559 A ARP980103559 A AR P980103559A AR 009892 A1 AR009892 A1 AR 009892A1
Authority
AR
Argentina
Prior art keywords
alkyl
application
compounds
diona
medicines
Prior art date
Application number
ARP980103559A
Other languages
English (en)
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR009892A1 publication Critical patent/AR009892A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Aplicacion de compuestos de imidazolidin-2,4-diona sustituidos de la formula general (I) en la cual R1 representa C1-6-alquilo o C3-6-alquilo y R2representa C1-6-alquilo, fenilo, -(CH2)1-3-fenilo o -(CH2)1-4-COOR5, o R1 y R2 conjuntamente representan -(CH2)4-6, -(CH2)2-O-(CH2)2- o (II) R3 representahidrogeno, C1-5-alquilo o (CH2)1-4-COOR5; R4 representa un nucleo heteroaromático elegido del grupo que comprende los de las formulas (II);R5 representa C1-3-alquilo; R6 representa hidrogeno, C1-4-alquilo, fenilo o bencilo; y R7 representa hidrogeno, C1-4-alquilo o trifluorometilo, para lapreparacion de un mediamento para el tratamiento del dolor.
ARP980103559A 1997-07-31 1998-07-21 Aplicacion de compuestos de imidazolidin-2,4-diona sustituidos, como medicamentos para el tratamiento del dolor AR009892A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732928A DE19732928C2 (de) 1997-07-31 1997-07-31 Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel

Publications (1)

Publication Number Publication Date
AR009892A1 true AR009892A1 (es) 2000-05-03

Family

ID=7837435

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103559A AR009892A1 (es) 1997-07-31 1998-07-21 Aplicacion de compuestos de imidazolidin-2,4-diona sustituidos, como medicamentos para el tratamiento del dolor

Country Status (23)

Country Link
US (1) US6022875A (es)
EP (1) EP0894497B1 (es)
JP (1) JPH1192370A (es)
KR (1) KR19990014290A (es)
CN (1) CN1160071C (es)
AR (1) AR009892A1 (es)
AT (1) ATE262903T1 (es)
AU (1) AU732955B2 (es)
CA (1) CA2244200A1 (es)
CO (1) CO5210886A1 (es)
DE (2) DE19732928C2 (es)
DK (1) DK0894497T3 (es)
ES (1) ES2219811T3 (es)
HK (1) HK1017264A1 (es)
HU (1) HUP9801711A3 (es)
IL (1) IL125583A (es)
NZ (1) NZ330667A (es)
PE (1) PE105499A1 (es)
PL (1) PL327767A1 (es)
PT (1) PT894497E (es)
RU (1) RU2195933C2 (es)
SI (1) SI0894497T1 (es)
ZA (1) ZA986829B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19927688A1 (de) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
DE19927689A1 (de) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Orale Darreichungsformen zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
DE19936521A1 (de) * 1999-08-06 2001-02-15 Gruenenthal Gmbh Substituierte Pyrrolidin-2,3,4-trion-3-oxim-Derivate
DE10059020A1 (de) * 2000-11-28 2002-05-29 Gruenenthal Gmbh Parenteral applizierbare Darreichungsformen
DE10210190A1 (de) * 2002-03-07 2003-09-25 Sanol Arznei Schwarz Gmbh Aza-Spiroverbindungen
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
WO2005000194A2 (en) * 2002-10-08 2005-01-06 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same
RU2338555C2 (ru) 2002-10-08 2008-11-20 Ринат Ньюросайенс Корп. Способы лечения послеоперационной боли введением антагониста фактора роста нервов и композиции, содержащие фактор роста нервов
UA80447C2 (en) * 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
EP1575517B1 (en) 2002-12-24 2012-04-11 Rinat Neuroscience Corp. Anti-ngf antibodies and methods using same
US7569364B2 (en) * 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2850652B1 (fr) * 2003-01-31 2008-05-30 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
EP1594441B1 (en) 2003-02-19 2010-12-15 Rinat Neuroscience Corp. Method for treating pain by administering a nerve growth factor antagonist and an nsaid and composition containing the same
US7199125B2 (en) * 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
CN1917876A (zh) * 2003-12-16 2007-02-21 Cns生物有限公司 方法和组合物
ITRM20030601A1 (it) * 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
AU2005243247B2 (en) * 2004-04-07 2012-03-01 Regents Of The University Of Minnesota Methods for treating bone cancer pain by administering a nerve growth factor antagonist
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621536A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
ITRM20050290A1 (it) * 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
DE102005061429A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxazol-Derivate
FR2896504B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896503B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
US7649007B2 (en) * 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
TW200815428A (en) 2006-08-15 2008-04-01 Wyeth Corp Oxazolidone derivatives as PR modulators
WO2008021309A1 (en) * 2006-08-15 2008-02-21 Wyeth Imidazolidin-2-one derivatives useful as pr modulators
KR20110077006A (ko) 2006-08-15 2011-07-06 노파르티스 아게 증가된 지질 수준과 관련된 질환의 치료에 적합한 헤테로시클릭 화합물
WO2008021337A1 (en) 2006-08-15 2008-02-21 Wyeth Oxazinan-2-one derivatives useful as pr modulators
KR20230095473A (ko) 2021-12-22 2023-06-29 최은지 당뇨환자를 위한 디저트, 감자양갱

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019731B2 (ja) * 1978-10-09 1985-05-17 協和醗酵工業株式会社 消炎鎮痛剤
WO1992007567A1 (en) * 1990-11-06 1992-05-14 Smithkline Beecham Corporation Imidazolidinone compounds
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19540027A1 (de) * 1995-10-27 1997-04-30 Gruenenthal Gmbh Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
JP3449084B2 (ja) * 1995-12-25 2003-09-22 富士レビオ株式会社 ヒダントイン誘導体
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
HUP9801711A2 (hu) 1999-03-29
HU9801711D0 (en) 1998-09-28
CO5210886A1 (es) 2002-10-30
IL125583A (en) 2002-09-12
SI0894497T1 (en) 2004-08-31
JPH1192370A (ja) 1999-04-06
DK0894497T3 (da) 2004-05-03
KR19990014290A (ko) 1999-02-25
ATE262903T1 (de) 2004-04-15
ZA986829B (en) 1999-02-02
AU732955B2 (en) 2001-05-03
IL125583A0 (en) 1999-03-12
HUP9801711A3 (en) 2000-01-28
CN1207291A (zh) 1999-02-10
US6022875A (en) 2000-02-08
RU2195933C2 (ru) 2003-01-10
EP0894497B1 (de) 2004-03-31
NZ330667A (en) 2000-09-29
PT894497E (pt) 2004-08-31
CN1160071C (zh) 2004-08-04
DE19732928A1 (de) 1999-02-04
PE105499A1 (es) 1999-11-27
DE59811080D1 (de) 2004-05-06
ES2219811T3 (es) 2004-12-01
EP0894497A1 (de) 1999-02-03
AU7868098A (en) 1999-02-11
HK1017264A1 (en) 1999-11-19
DE19732928C2 (de) 2000-05-18
CA2244200A1 (en) 1999-01-31
PL327767A1 (en) 1999-02-01

Similar Documents

Publication Publication Date Title
AR009892A1 (es) Aplicacion de compuestos de imidazolidin-2,4-diona sustituidos, como medicamentos para el tratamiento del dolor
AR004517A1 (es) Compuestos de imidazolin-2-4 diona sustituida, procedimiento de preparacion de dichos compuestos, y aplicacion para el uso de estos compuestos
TR200003206T2 (tr) İndol türevleri ve patolojik hücre çoğalmasının neden olduğu habis hastalıklar ve diğer hastalıkların tedavisinde kullanımları.
AR023727A1 (es) Compuestos empleados en el tratamiento de padecimientos inflamatorios
BR0113643A (pt) Compostos de guanidinobenzamidas como agonistas de mc4-r e seus usos
BR0116217A (pt) Quinolonas antimicrobianas, composição farmacêutica, bem como aplicação farmacêutica das referidas quinolonas
CY1107080T1 (el) Υποκατεστημενες ινδολο-βασεις του mannich
AR028948A1 (es) Compuestos novedosos
AR013153A1 (es) Derivados de 2-arildihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados, y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n.
TR199901077A2 (en) �spen�iyari form�lasyonlar.
AR028810A1 (es) Derivados de arilpiperazinil-ciclohexil indol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos para el tratamiento de la depresion
BRPI0417717A (pt) composto, composição farmacêutica, e, uso de um composto
PA8593101A1 (es) Composiciones para el tratamiento de crecimiento celular anormal
SV2002000195A (es) Compuestos farmaceuticamente activos ref. pcs10342 afae/bb
TR200001840T2 (tr) Arile bağlı azopolisiklik bileşikler
DE60045508D1 (de) Dalda-analoge und ihre verwendung
CO6140035A2 (es) Derivados de bencimidazol 5-sulfonamida como ligandos del receptor cannabinoide 1 (cb1)
PE20040698A1 (es) Derivados de isoindolina
TR200002380T2 (tr) Yeni triazolo (4,5-d) pirimidin bileşikleri
UY28536A1 (es) Derivados de bencimidazol, composiciones que los contienen, preparacion y usos de los mismos.
AR016551A1 (es) Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos
ES2182546T3 (es) Imidazo(1,2a)azinas sustituidas como inhibidores selectivos de la cox-2.
UY26988A1 (es) Nuevas indolinonas sustituidas, su preparación y su utilización como medicamentos.
PA8583801A1 (es) Piperazinas sustituidas heterocíclicas para el tratamiento de la esquizofrenia
ES2111492B1 (es) Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central.

Legal Events

Date Code Title Description
FB Suspension of granting procedure