CO5210886A1 - Aplicacion de compuestos de imidazolidin-2, 4-diona susti- tuida como antalgicos - Google Patents

Aplicacion de compuestos de imidazolidin-2, 4-diona susti- tuida como antalgicos

Info

Publication number
CO5210886A1
CO5210886A1 CO98043532A CO98043532A CO5210886A1 CO 5210886 A1 CO5210886 A1 CO 5210886A1 CO 98043532 A CO98043532 A CO 98043532A CO 98043532 A CO98043532 A CO 98043532A CO 5210886 A1 CO5210886 A1 CO 5210886A1
Authority
CO
Colombia
Prior art keywords
alkyl
imidazolidin
antalgical
diona
composite application
Prior art date
Application number
CO98043532A
Other languages
English (en)
Inventor
Oswald Zimmer
Norma Selve
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of CO5210886A1 publication Critical patent/CO5210886A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de imidazolidin-diona para la preparación de medicamentos antiálgicos, CARACTERIZADOS porque comprenden compuestos de imidazolidin-2,4-diona sustituidos de la formula I<EMI FILE="98043532_1" ID="1" IMF=JPEG >en la cual R1 representa C1-C6-alquilo o C3-C6-alquilo y R2 representa C1-C6-alquilo, fenilo, -(CH2)1-3-fenilo o -(CH2)1-4-COOR5, ó R1 y R2 conjuntamente representan -(CH2)4-6, -(CH2)2- O-(CH2)2- ó <EMI FILE="98043532_2" ID="2" IMF=JPEG >R3 representa hidrógeno, C1-C5-alquilo ó -(CH2)1-4-COOR5, R4 representa un núcleo heteroaromático elegido del grupo que comprende los de las fórmulas<EMI FILE="98043532_3" ID="3" IMF=JPEG >R5 representa C1-C3-alquilo. R6 representa hidrógeno, C1-C4-alquilo, fenilo o bencilo, y R7 representa hidrógeno, C1-C4-alquilo o trifluorometilo.
CO98043532A 1997-07-31 1998-07-30 Aplicacion de compuestos de imidazolidin-2, 4-diona susti- tuida como antalgicos CO5210886A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732928A DE19732928C2 (de) 1997-07-31 1997-07-31 Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel

Publications (1)

Publication Number Publication Date
CO5210886A1 true CO5210886A1 (es) 2002-10-30

Family

ID=7837435

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98043532A CO5210886A1 (es) 1997-07-31 1998-07-30 Aplicacion de compuestos de imidazolidin-2, 4-diona susti- tuida como antalgicos

Country Status (23)

Country Link
US (1) US6022875A (es)
EP (1) EP0894497B1 (es)
JP (1) JPH1192370A (es)
KR (1) KR19990014290A (es)
CN (1) CN1160071C (es)
AR (1) AR009892A1 (es)
AT (1) ATE262903T1 (es)
AU (1) AU732955B2 (es)
CA (1) CA2244200A1 (es)
CO (1) CO5210886A1 (es)
DE (2) DE19732928C2 (es)
DK (1) DK0894497T3 (es)
ES (1) ES2219811T3 (es)
HK (1) HK1017264A1 (es)
HU (1) HUP9801711A3 (es)
IL (1) IL125583A (es)
NZ (1) NZ330667A (es)
PE (1) PE105499A1 (es)
PL (1) PL327767A1 (es)
PT (1) PT894497E (es)
RU (1) RU2195933C2 (es)
SI (1) SI0894497T1 (es)
ZA (1) ZA986829B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19927688A1 (de) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
DE19927689A1 (de) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Orale Darreichungsformen zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
DE19936521A1 (de) * 1999-08-06 2001-02-15 Gruenenthal Gmbh Substituierte Pyrrolidin-2,3,4-trion-3-oxim-Derivate
DE10059020A1 (de) 2000-11-28 2002-05-29 Gruenenthal Gmbh Parenteral applizierbare Darreichungsformen
DE10210190A1 (de) * 2002-03-07 2003-09-25 Sanol Arznei Schwarz Gmbh Aza-Spiroverbindungen
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
BR0315164A (pt) 2002-10-08 2005-08-23 Rinat Neuroscience Corp Métodos para tratar dor pós-cirúrgica administrando um antagonista de fator de crescimento nervoso e composições contendo o mesmo
WO2005000194A2 (en) * 2002-10-08 2005-01-06 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same
UA80447C2 (en) * 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US7569364B2 (en) * 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
SI1575517T1 (sl) 2002-12-24 2012-06-29 Rinat Neuroscience Corp Protitelesa proti ĺ˝iväśnemu rastnemu dejavniku in metode njihove uporabe
US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2850652B1 (fr) * 2003-01-31 2008-05-30 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
ATE491444T1 (de) 2003-02-19 2011-01-15 Rinat Neuroscience Corp Verfahren zur behandlung von schmerzen durch verabreichung eines nervenwachstumsfaktor- antagonisten und eines nsaid und diese enthaltende zusammensetzung
US7199125B2 (en) * 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US8334263B2 (en) * 2003-12-16 2012-12-18 Raymond Nadeson Analgesic methods and compositions
ITRM20030601A1 (it) * 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
ES2338344T3 (es) * 2004-04-07 2010-05-06 Rinat Neuroscience Corporation Procedimiento de tratamiento del dolor de cancer de hueso mediante la administracion de una antagonista del factor de crecimiento neuronal.
EP1621536A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
ITRM20050290A1 (it) * 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
DE102005061429A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxazol-Derivate
FR2896504B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896503B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
US7649007B2 (en) * 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
TW200815428A (en) 2006-08-15 2008-04-01 Wyeth Corp Oxazolidone derivatives as PR modulators
RU2009109147A (ru) * 2006-08-15 2010-09-27 Новартис АГ (CH) Органические соединения
US7652018B2 (en) * 2006-08-15 2010-01-26 Wyeth Llc Imidazolidin-2-one derivatives useful as PR modulators
WO2008021337A1 (en) 2006-08-15 2008-02-21 Wyeth Oxazinan-2-one derivatives useful as pr modulators
KR20230095473A (ko) 2021-12-22 2023-06-29 최은지 당뇨환자를 위한 디저트, 감자양갱

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019731B2 (ja) * 1978-10-09 1985-05-17 協和醗酵工業株式会社 消炎鎮痛剤
CA2095429A1 (en) * 1990-11-06 1992-05-07 Paul E. Bender Imidazolidinone compounds
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19540027A1 (de) * 1995-10-27 1997-04-30 Gruenenthal Gmbh Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
JP3449084B2 (ja) * 1995-12-25 2003-09-22 富士レビオ株式会社 ヒダントイン誘導体
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
HUP9801711A3 (en) 2000-01-28
DE59811080D1 (de) 2004-05-06
EP0894497A1 (de) 1999-02-03
HUP9801711A2 (hu) 1999-03-29
CN1160071C (zh) 2004-08-04
PE105499A1 (es) 1999-11-27
HK1017264A1 (en) 1999-11-19
CA2244200A1 (en) 1999-01-31
PL327767A1 (en) 1999-02-01
EP0894497B1 (de) 2004-03-31
DE19732928A1 (de) 1999-02-04
HU9801711D0 (en) 1998-09-28
AU7868098A (en) 1999-02-11
ATE262903T1 (de) 2004-04-15
AR009892A1 (es) 2000-05-03
DK0894497T3 (da) 2004-05-03
ES2219811T3 (es) 2004-12-01
KR19990014290A (ko) 1999-02-25
ZA986829B (en) 1999-02-02
US6022875A (en) 2000-02-08
IL125583A0 (en) 1999-03-12
RU2195933C2 (ru) 2003-01-10
JPH1192370A (ja) 1999-04-06
NZ330667A (en) 2000-09-29
DE19732928C2 (de) 2000-05-18
AU732955B2 (en) 2001-05-03
SI0894497T1 (en) 2004-08-31
IL125583A (en) 2002-09-12
PT894497E (pt) 2004-08-31
CN1207291A (zh) 1999-02-10

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