AR008993A1 - Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos - Google Patents

Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos

Info

Publication number
AR008993A1
AR008993A1 ARP970102405A ARP970102405A AR008993A1 AR 008993 A1 AR008993 A1 AR 008993A1 AR P970102405 A ARP970102405 A AR P970102405A AR P970102405 A ARP970102405 A AR P970102405A AR 008993 A1 AR008993 A1 AR 008993A1
Authority
AR
Argentina
Prior art keywords
phenyl
methyl
salts
propionics
imidazolidin
Prior art date
Application number
ARP970102405A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of AR008993A1 publication Critical patent/AR008993A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Concierne a sales de ésteres etílicos de ácidos 3-(2-(4-(4-(amino-imino- metil)-fenil)-4-metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos de la formula general (I), en la que HB significa ácido maleico, así como sus salesfis iologicamente compatibles, a procedimientos para supreparacion y a su utilizacion en medicamentos.
ARP970102405A 1996-06-05 1997-06-03 Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos AR008993A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19622489A DE19622489A1 (de) 1996-06-05 1996-06-05 Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters

Publications (1)

Publication Number Publication Date
AR008993A1 true AR008993A1 (es) 2000-03-08

Family

ID=7796165

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102405A AR008993A1 (es) 1996-06-05 1997-06-03 Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos

Country Status (24)

Country Link
US (1) US6294562B1 (es)
EP (1) EP0811616B1 (es)
JP (1) JP4249277B2 (es)
KR (1) KR980002029A (es)
CN (1) CN1104420C (es)
AR (1) AR008993A1 (es)
AT (1) ATE294783T1 (es)
AU (1) AU717106B2 (es)
BR (1) BR9703459A (es)
CA (1) CA2206748C (es)
CZ (1) CZ292672B6 (es)
DE (2) DE19622489A1 (es)
ES (1) ES2241016T3 (es)
HK (1) HK1006359A1 (es)
HR (1) HRP970309B1 (es)
HU (1) HUP9700998A3 (es)
IL (1) IL120984A (es)
MX (1) MX9704128A (es)
NO (1) NO307999B1 (es)
PL (1) PL320355A1 (es)
RU (1) RU2174119C2 (es)
SK (1) SK70897A3 (es)
TR (1) TR199700457A2 (es)
ZA (1) ZA974912B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19647380A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
KR20060058728A (ko) * 2003-10-02 2006-05-30 파마시아 앤드 업존 캄파니 엘엘씨 피롤-치환된 인돌리논 화합물의 염 및 다형체
US20090298814A1 (en) * 2005-06-07 2009-12-03 Ramot At Tel Aviv Univeristy Ltd Novel salts of conjugated psychotropic drugs and processes of preparing same
CN101511388B (zh) 2006-07-17 2012-10-24 特拉维夫大学拉莫特有限公司 含有精神药物或gaba激动剂和有机酸的缀合物以及它们在治疗疼痛和其它cns疾病中的用途
US8207369B2 (en) 2008-02-11 2012-06-26 Ramot At Tel-Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
EP2509603A1 (en) 2009-12-09 2012-10-17 Biolinerx Ltd. Methods of improving cognitive functions
JP2013520488A (ja) 2010-02-24 2013-06-06 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド ペルフェナジン−ｇａｂａのトリメシラート塩の結晶性形態物及びその製法方法
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same
EP3773573A4 (en) 2018-04-12 2022-04-06 Morphic Therapeutic, Inc. ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4) (BETA7)
TWI775182B (zh) 2019-10-16 2022-08-21 美商莫菲克醫療股份有限公司 抑制人類整合素αβ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de) 1992-07-24 1994-01-27 Cassella Ag Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
DE4308034A1 (de) 1993-03-13 1994-09-15 Cassella Ag Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4309867A1 (de) 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
DE4427979A1 (de) 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
DE19515177A1 (de) 1995-04-28 1996-10-31 Cassella Ag Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
HUP9700998A3 (en) 1999-03-01
CN1104420C (zh) 2003-04-02
IL120984A0 (en) 1997-11-20
TR199700457A2 (xx) 1997-12-21
EP0811616B1 (de) 2005-05-04
CA2206748C (en) 2007-05-01
JP4249277B2 (ja) 2009-04-02
DE19622489A1 (de) 1997-12-11
IL120984A (en) 2001-08-26
PL320355A1 (en) 1997-12-08
ATE294783T1 (de) 2005-05-15
KR980002029A (ko) 1998-03-30
DE59712294D1 (de) 2005-06-09
ZA974912B (en) 1997-12-05
CN1174835A (zh) 1998-03-04
SK70897A3 (en) 1999-05-07
MX9704128A (es) 1997-12-31
BR9703459A (pt) 1998-10-06
US6294562B1 (en) 2001-09-25
CZ292672B6 (cs) 2003-11-12
HK1006359A1 (en) 1999-02-26
HU9700998D0 (en) 1997-07-28
JPH1059948A (ja) 1998-03-03
ES2241016T3 (es) 2005-10-16
RU2174119C2 (ru) 2001-09-27
NO972506D0 (no) 1997-06-02
EP0811616A1 (de) 1997-12-10
NO972506L (no) 1997-12-08
CZ172997A3 (en) 1997-12-17
HRP970309A2 (en) 1998-04-30
AU2467497A (en) 1997-12-11
HRP970309B1 (en) 2002-06-30
CA2206748A1 (en) 1997-12-05
HUP9700998A1 (hu) 1998-03-30
AU717106B2 (en) 2000-03-16
NO307999B1 (no) 2000-07-03

Similar Documents

Publication Publication Date Title
AR008993A1 (es) Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos
ATE420876T1 (de) Propansäurederivate die die bindung von integrinen an ihre rezeptoren hemmen
NO20015394L (no) Karboksylsyrederivater som hemmer bindingen av integriner til deres reseptorer
PE20020340A1 (es) Composicion farmaceutica que comprende ester etilico de acido [2r,4s]-4-[(3,5-bis-trifluorometilbencil)metoxicarbonilamino]-2-etil-6-trifluorometil-3,4-dihidro-2h-quinolina-1-carboxilico y atorvastatina o sus metabolitos hidroxilicos
ATE383153T1 (de) Carbonsäurederivate die die bindung von integrinen an ihre rezeptoren hemmen
AR024944A1 (es) Amidas de acidos carboxilicos, medicamentos que contienen estos compuestos, su utilizacion y su preparacion
EA200401136A1 (ru) Предназначенная для перорального применения лекарственная форма для этилового эфира 3-[(2-{[4-(гексилоксикарбониламиноиминометил)фениламино]метил}-1-метил-1h-бензимидазол-5-карбонил)пиридин-2-иламино]пропионовой кислоты и его солей
DE60210567D1 (de) Zusammensetzung zum oxidativen Färben von Keratinfasern, die eine alkoxylierte Ethercarbonsäure, ein assoziatives Polymer und einen ungesättigten Fettalkohol enthält
CO4940466A1 (es) Sales metanosulfonato de 5-(2-(4-(1,2-benzoisotiazol-3-il)- 1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona dihidratadas
CO5261552A1 (es) Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidas
DK0611767T3 (da) Heterocyclisk substituerede phenylcyclohexancarboxylsyrederivater som angiotension II-antagonister
CH700328B8 (de) O/W-Emulsion zur Pflege der Hand.
DE69415018T2 (de) Oralanzuwendende flüssige arzneizubereitung enthaltend 2-(4-isobutylphenyl)propionsäure
FR2849597B1 (fr) Composition cosmetique pour le soin des peaux grasses, contenant un acide gras carboxylique ou l'un de ses derives
BR0112245A (pt) éster de ácido 4-alcóxi-ciclohexano-1-amino-carboxìlico e processo para sua preparação
AR040763A1 (es) Profarmacos de la (n-2- piridil-n-2- hidroxicarbonil-etil) - amida del acido 1- metil-2-(4-amidinofenilaminometil)-- benzimidazol-5-il-carboxilico, su preparacion y su utilizacion como medicamentos
ES2191099T3 (es) Derivados de hidantoina como productos intermedios para principios activos farmaceuticos.
BR0113809A (pt) Composições farmacêuticas
DE69518073T2 (de) Pyrazol-Carbonsäurederivate als Mittel zur Bekämpfung von Pflanzenkrankheiten
DK0888340T3 (da) 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin
AR247327A1 (es) Una composicion herbicida
AR017426A1 (es) Sal de monoargininilo del acido (e)-3-[1-n-butil-5-[2-(2-carboxifenil)metoxi-4-clorofenil]-1h-pirazol-4-il]-2-[(5-metoxi-2,3-dihidrobenzofuran-6-il)metil]-prop-2-enoico, composicion farmaceutica que la contiene, su uso para la manufactura de un medicamento y procedimiento para su preparacion
AR005878A1 (es) Procedimiento para la elaboracion del ester metilico del acido 2-(2- metilfenil)-3-metoxiacrilico
PT746551E (pt) Acidos 4-aril-2-hidroxitetronicos opticamente puros
BR0307490A (pt) Derivado de piperidina e composição farmacêutica que compreende o mesmo como ingrediente ativo