HUP9700998A1 - 3-(2-(4-(4-(Amino-imino-metil)-fenil)-4-metil-2,5-dioxo-imidazolidin-1-il)-acetil-amino)-3-fenil-propionsav-etilészter maleinsav sói, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents

3-(2-(4-(4-(Amino-imino-metil)-fenil)-4-metil-2,5-dioxo-imidazolidin-1-il)-acetil-amino)-3-fenil-propionsav-etilészter maleinsav sói, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

Info

Publication number
HUP9700998A1
HUP9700998A1 HU9700998A HUP9700998A HUP9700998A1 HU P9700998 A1 HUP9700998 A1 HU P9700998A1 HU 9700998 A HU9700998 A HU 9700998A HU P9700998 A HUP9700998 A HU P9700998A HU P9700998 A1 HUP9700998 A1 HU P9700998A1
Authority
HU
Hungary
Prior art keywords
methyl
phenyl
amino
imidazolidin
dioxo
Prior art date
Application number
HU9700998A
Other languages
English (en)
Inventor
Gerhard Beck
Manfred Radau
Hans Ulrich Stilz
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of HU9700998D0 publication Critical patent/HU9700998D0/hu
Publication of HUP9700998A1 publication Critical patent/HUP9700998A1/hu
Publication of HUP9700998A3 publication Critical patent/HUP9700998A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány tárgya sejt-sejt adhézió gátló hatású, (I) általánősképletű 3-[2-{4-[4-(aminő-iminő-metil)-fenil)]-4-metil-2,5-diőxő-imidazőlidin-1-il]}-acetil-aminő}]-3-fenil-prőpiőnsav-etilészter sók -a képletben HB jelentése maleinsav -, ennek összes sztereőizőmerfőrmája és a sztereőizőmerek tetszés szerinti keveréke, valamintfiziőlógiásan elfőgadható sói. A találmány vőnatkőzik tővábbá a fenti (I) általánős képletűvegyületek előállítási eljárására is. ŕ
HU9700998A 1996-06-05 1997-06-04 Maleic acid salts of 3-(2-(4-(4-(amino-imino-methyl)-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3-phenyl propionicacid ethylester, pharmaceutical compositons containing them and process for producing them HUP9700998A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19622489A DE19622489A1 (de) 1996-06-05 1996-06-05 Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters

Publications (3)

Publication Number Publication Date
HU9700998D0 HU9700998D0 (en) 1997-07-28
HUP9700998A1 true HUP9700998A1 (hu) 1998-03-30
HUP9700998A3 HUP9700998A3 (en) 1999-03-01

Family

ID=7796165

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700998A HUP9700998A3 (en) 1996-06-05 1997-06-04 Maleic acid salts of 3-(2-(4-(4-(amino-imino-methyl)-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3-phenyl propionicacid ethylester, pharmaceutical compositons containing them and process for producing them

Country Status (24)

Country Link
US (1) US6294562B1 (hu)
EP (1) EP0811616B1 (hu)
JP (1) JP4249277B2 (hu)
KR (1) KR980002029A (hu)
CN (1) CN1104420C (hu)
AR (1) AR008993A1 (hu)
AT (1) ATE294783T1 (hu)
AU (1) AU717106B2 (hu)
BR (1) BR9703459A (hu)
CA (1) CA2206748C (hu)
CZ (1) CZ292672B6 (hu)
DE (2) DE19622489A1 (hu)
ES (1) ES2241016T3 (hu)
HK (1) HK1006359A1 (hu)
HR (1) HRP970309B1 (hu)
HU (1) HUP9700998A3 (hu)
IL (1) IL120984A (hu)
MX (1) MX9704128A (hu)
NO (1) NO307999B1 (hu)
PL (1) PL320355A1 (hu)
RU (1) RU2174119C2 (hu)
SK (1) SK70897A3 (hu)
TR (1) TR199700457A2 (hu)
ZA (1) ZA974912B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19647380A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
DK1670785T3 (da) * 2003-10-02 2010-10-18 Pharmacia & Upjohn Co Llc Salte og polymorphe former af en pyrrolsubstitueret indolinonforbindelse
MX2007015511A (es) * 2005-06-07 2008-03-06 Univ Ramot Sales novedosas de farmacos sicotropicos conjugados y procesos para prepararlas.
EP2051735B1 (en) 2006-07-17 2012-08-29 Ramot, at Tel Aviv University Ltd. Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders
WO2009101616A1 (en) 2008-02-11 2009-08-20 Ramot At Tel Aviv University Ltd. Novel conjugates for treating neurodegenerative diseases and disorders
US8975251B2 (en) 2009-12-09 2015-03-10 Bar-Ilan University Methods of improving cognitive functions
WO2011104637A2 (en) 2010-02-24 2011-09-01 Ramot At Tel-Aviv University Ltd. Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same
MA52249A (fr) * 2018-04-12 2021-05-05 Morphic Therapeutic Inc Antagonistes de l'intégrine humaine (alpha4) (beta7)
AR120244A1 (es) 2019-10-16 2022-02-09 Morphic Therapeutic Inc INHIBICIÓN DE INTEGRINA a4b7 HUMANA

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de) 1992-07-24 1994-01-27 Cassella Ag Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
DE4308034A1 (de) 1993-03-13 1994-09-15 Cassella Ag Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4309867A1 (de) 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
DE4427979A1 (de) * 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
DE19515177A1 (de) 1995-04-28 1996-10-31 Cassella Ag Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
ES2241016T3 (es) 2005-10-16
JP4249277B2 (ja) 2009-04-02
AU2467497A (en) 1997-12-11
HRP970309A2 (en) 1998-04-30
IL120984A (en) 2001-08-26
IL120984A0 (en) 1997-11-20
CN1104420C (zh) 2003-04-02
NO972506D0 (no) 1997-06-02
HUP9700998A3 (en) 1999-03-01
SK70897A3 (en) 1999-05-07
AR008993A1 (es) 2000-03-08
BR9703459A (pt) 1998-10-06
KR980002029A (ko) 1998-03-30
HK1006359A1 (en) 1999-02-26
EP0811616A1 (de) 1997-12-10
NO972506L (no) 1997-12-08
DE19622489A1 (de) 1997-12-11
NO307999B1 (no) 2000-07-03
ATE294783T1 (de) 2005-05-15
CZ172997A3 (en) 1997-12-17
TR199700457A2 (xx) 1997-12-21
AU717106B2 (en) 2000-03-16
HU9700998D0 (en) 1997-07-28
RU2174119C2 (ru) 2001-09-27
ZA974912B (en) 1997-12-05
MX9704128A (es) 1997-12-31
US6294562B1 (en) 2001-09-25
CN1174835A (zh) 1998-03-04
DE59712294D1 (de) 2005-06-09
JPH1059948A (ja) 1998-03-03
EP0811616B1 (de) 2005-05-04
CA2206748C (en) 2007-05-01
CA2206748A1 (en) 1997-12-05
HRP970309B1 (en) 2002-06-30
PL320355A1 (en) 1997-12-08
CZ292672B6 (cs) 2003-11-12

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