AR003436A1 - Ligandos de p-seletina y moleculas, acidos nucleicos purificados, vector, celula y uso de dichas moleculas para preparar medicamentos. - Google Patents
Ligandos de p-seletina y moleculas, acidos nucleicos purificados, vector, celula y uso de dichas moleculas para preparar medicamentos.Info
- Publication number
- AR003436A1 AR003436A1 ARP960103147A AR10314796A AR003436A1 AR 003436 A1 AR003436 A1 AR 003436A1 AR P960103147 A ARP960103147 A AR P960103147A AR 10314796 A AR10314796 A AR 10314796A AR 003436 A1 AR003436 A1 AR 003436A1
- Authority
- AR
- Argentina
- Prior art keywords
- molecules
- ligands
- nucleic acids
- purified nucleic
- seletine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/473—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used alpha-Glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Se describen aquí las moléculas orgánicas a las que están unidos covalentamente un determinante de sialil-Le(x) y un determinante sulfatado, almenos uno de estos determinantes está ubicado en un sitio de ocurrencia no natural en la molécula.También están descriptos los ligandos particulares de laP-selectina y las fusiones del anticuerpo con el ligando de la P.selectina. Estas moléculas, ligandos, y proteínas de fusión son útiles en la reducción yprotección contra la inflamación y las reacciones adversas dependientes de la extravasación, tal como el dano orgánico o coagulación (por ejemplo, asociadocon el síndrome de deficiencia respiratoria del adulto o dano isquémico del miocardio). Asimismo, se describen ácidos nucléicos purificados, vectores,células y el uso de dichas moléculas para preparar medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21395P | 1995-06-14 | 1995-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR003436A1 true AR003436A1 (es) | 1998-08-05 |
Family
ID=21690430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960103147A AR003436A1 (es) | 1995-06-14 | 1996-06-13 | Ligandos de p-seletina y moleculas, acidos nucleicos purificados, vector, celula y uso de dichas moleculas para preparar medicamentos. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0833650A4 (es) |
JP (1) | JPH11508131A (es) |
KR (1) | KR19990022954A (es) |
AR (1) | AR003436A1 (es) |
AU (1) | AU6272996A (es) |
BR (1) | BR9608918A (es) |
CA (1) | CA2224625A1 (es) |
CZ (1) | CZ401497A3 (es) |
HU (1) | HUP9901131A2 (es) |
IL (1) | IL122590A0 (es) |
NO (1) | NO975862L (es) |
TR (1) | TR199701620T1 (es) |
WO (1) | WO1997000079A1 (es) |
ZA (1) | ZA965032B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999043834A2 (en) * | 1998-02-27 | 1999-09-02 | Genetics Institute, Inc. | P-selectin ligand protein, including tetrameric fusion proteins |
MXPA03005945A (es) * | 2000-12-29 | 2004-10-15 | Savient Pharmaceuticals Inc | Moleculas aisladas que comprenden epitopes que contienen grupos sulfato, anticuerpos para tales epitopes y usos de ellos. |
JP4599027B2 (ja) * | 2002-10-30 | 2010-12-15 | 東洋水産株式会社 | L−セレクチン結合阻害剤 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0544815A1 (en) * | 1990-07-17 | 1993-06-09 | The Board Of Regents Of The University Of Oklahoma | Peptides from the GMP-140 lectinbindingdomain and selectin binding ligands on carbonhydrates |
US5318890A (en) * | 1991-05-06 | 1994-06-07 | The Regents Of The University Of California | Assays for inhibitors of leukocyte adhesion |
AU681369B2 (en) * | 1992-11-16 | 1997-08-28 | Board Of Regents Of The University Of Oklahoma, The | Glycoprotein ligand for P-selectin and methods of use thereof |
WO1995030001A2 (en) * | 1994-04-28 | 1995-11-09 | Genetics Institute, Inc. | Novel p-selectin ligand protein |
-
1996
- 1996-06-11 WO PCT/US1996/010043 patent/WO1997000079A1/en not_active Application Discontinuation
- 1996-06-11 TR TR97/01620T patent/TR199701620T1/xx unknown
- 1996-06-11 KR KR1019970709424A patent/KR19990022954A/ko not_active Application Discontinuation
- 1996-06-11 JP JP9503258A patent/JPH11508131A/ja active Pending
- 1996-06-11 IL IL12259096A patent/IL122590A0/xx unknown
- 1996-06-11 CZ CZ974014A patent/CZ401497A3/cs unknown
- 1996-06-11 BR BR9608918A patent/BR9608918A/pt not_active Application Discontinuation
- 1996-06-11 HU HU9901131A patent/HUP9901131A2/hu unknown
- 1996-06-11 EP EP96921519A patent/EP0833650A4/en not_active Withdrawn
- 1996-06-11 AU AU62729/96A patent/AU6272996A/en not_active Abandoned
- 1996-06-11 CA CA002224625A patent/CA2224625A1/en not_active Abandoned
- 1996-06-13 AR ARP960103147A patent/AR003436A1/es unknown
- 1996-06-13 ZA ZA965032A patent/ZA965032B/xx unknown
-
1997
- 1997-12-12 NO NO975862A patent/NO975862L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CZ401497A3 (cs) | 1998-07-15 |
IL122590A0 (en) | 1998-06-15 |
ZA965032B (en) | 1997-03-14 |
NO975862L (no) | 1998-02-12 |
CA2224625A1 (en) | 1997-01-03 |
AU6272996A (en) | 1997-01-15 |
KR19990022954A (ko) | 1999-03-25 |
TR199701620T1 (xx) | 1998-05-21 |
EP0833650A1 (en) | 1998-04-08 |
JPH11508131A (ja) | 1999-07-21 |
NO975862D0 (no) | 1997-12-12 |
BR9608918A (pt) | 1999-06-15 |
EP0833650A4 (en) | 2005-01-19 |
WO1997000079A1 (en) | 1997-01-03 |
HUP9901131A2 (hu) | 1999-07-28 |
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