AR002959A1 - 2,3-dihidro-1,4-dioxinopiridinas substituidas vasoconstrictoras, procedimientos para su preparacion, su uso para la preparacion de una composicion, intermediarias utiles en dichos procedimientos y una composicion farmaceutica que las contiene - Google Patents
2,3-dihidro-1,4-dioxinopiridinas substituidas vasoconstrictoras, procedimientos para su preparacion, su uso para la preparacion de una composicion, intermediarias utiles en dichos procedimientos y una composicion farmaceutica que las contieneInfo
- Publication number
- AR002959A1 AR002959A1 ARP960101287A AR10128796A AR002959A1 AR 002959 A1 AR002959 A1 AR 002959A1 AR P960101287 A ARP960101287 A AR P960101287A AR 10128796 A AR10128796 A AR 10128796A AR 002959 A1 AR002959 A1 AR 002959A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- alkyl
- procedures
- hydrogen
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a 2,3-dihidro-1,4-dioxinopiridinas substituidas vasoconstrictoras de fórmula (I) a las formas de N-óxido, a lassales de adición farmacéuticamente aceptables y a las formas estereoquímicament e isoméricas delas mismas, donde =a1-a2=a3-a4= es unradical bivalente de fórmula =N-CH=CH-CH= (a), =CH-N=CH-CH= (b), =CH-CH=N-CH= (c), =CH-CH=CH-N= (d), donde uno o dos átomos de hidrógeno pueden estarsubstituidos con halo, hidroxi, alquilo C1-6 o alquiloxiC1-6; R1 es hidroxi o alquilo C1-6; R2 es hidrógeno o alquilo C1-6; R3 es hidrógeno o alquilo C1-6;Alk1 es alcanodiilo C1-5; Alk2 es alcanodiilo C2-15; Q es un anillo heterocíclico de 5 a 6 miembros que contiene por lo menos un átomode nitrógenoo un radical de fórmula -C(NR5R6)=C-R4 donde R4 es hidrógeno, ciano, aminocarbonilo o alquilo C1-6; R5 es hidrógeno, alquilo C1-6, alquenilo C3-6 óalquinilo C3-6; R6 es hidrógeno o alquilo C1-6; ó R5 y R6 tomados conjuntamente pueden formar un radical bivalente de fórmula R-(CH2)4- ó -(CH2)5-. Sedescribe además un procedimiento para su preparación, su uso para la preparación de un medicamento, intermediarios de los mismos, composiciónfarmacéutica quel os contiene y un procedimiento para la preparación de dicha composición farmacéutica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95200290 | 1995-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR002959A1 true AR002959A1 (es) | 1998-05-27 |
Family
ID=8219997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960101287A AR002959A1 (es) | 1995-02-07 | 1996-02-06 | 2,3-dihidro-1,4-dioxinopiridinas substituidas vasoconstrictoras, procedimientos para su preparacion, su uso para la preparacion de una composicion, intermediarias utiles en dichos procedimientos y una composicion farmaceutica que las contiene |
Country Status (16)
Country | Link |
---|---|
US (1) | US5990123A (es) |
EP (1) | EP0808316B9 (es) |
JP (1) | JP4093431B2 (es) |
KR (1) | KR100412070B1 (es) |
AR (1) | AR002959A1 (es) |
AT (1) | ATE263170T1 (es) |
AU (1) | AU692361B2 (es) |
DE (1) | DE69632032T2 (es) |
ES (1) | ES2218582T3 (es) |
FI (1) | FI113774B (es) |
IL (1) | IL117045A (es) |
MY (1) | MY113426A (es) |
NO (1) | NO315237B1 (es) |
TW (1) | TW446706B (es) |
WO (1) | WO1996024596A1 (es) |
ZA (1) | ZA96933B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6656950B2 (en) | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
US6821981B2 (en) | 2001-04-26 | 2004-11-23 | Wyeth | Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists |
WO2004106298A1 (en) * | 2003-05-30 | 2004-12-09 | Janssen Pharmaceutica N.V. | Indole derivatives with an improved antipsychotic activity |
RU2007110731A (ru) * | 2004-09-23 | 2008-10-27 | Редди Юс Терапевтикс | Новые соединения пиримидина, способ их получения и содержащие их композиции |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1254496B (it) * | 1992-03-05 | 1995-09-25 | Enichem Spa | Preparazione di copolimeri alternati olefine/ossido di carbonio per mezzo di un catalizzatore eterogeneo supportato |
ZA931343B (en) * | 1992-03-06 | 1993-09-24 | Akzo Nv | 1,4-dioxino(2,3-b)pyridine derivatives. |
DE4226527A1 (de) * | 1992-08-11 | 1994-02-17 | Merck Patent Gmbh | 1,4-Benzodioxanderivate |
-
1996
- 1996-01-29 TW TW085101041A patent/TW446706B/zh not_active IP Right Cessation
- 1996-01-30 KR KR1019970705318A patent/KR100412070B1/ko active IP Right Grant
- 1996-01-30 ES ES96903952T patent/ES2218582T3/es not_active Expired - Lifetime
- 1996-01-30 WO PCT/EP1996/000396 patent/WO1996024596A1/en active IP Right Grant
- 1996-01-30 EP EP96903952A patent/EP0808316B9/en not_active Expired - Lifetime
- 1996-01-30 AT AT96903952T patent/ATE263170T1/de not_active IP Right Cessation
- 1996-01-30 AU AU47856/96A patent/AU692361B2/en not_active Expired
- 1996-01-30 DE DE69632032T patent/DE69632032T2/de not_active Expired - Lifetime
- 1996-01-30 JP JP52394996A patent/JP4093431B2/ja not_active Expired - Lifetime
- 1996-01-30 US US08/875,835 patent/US5990123A/en not_active Expired - Lifetime
- 1996-02-06 IL IL11704596A patent/IL117045A/xx not_active IP Right Cessation
- 1996-02-06 ZA ZA9600933A patent/ZA96933B/xx unknown
- 1996-02-06 AR ARP960101287A patent/AR002959A1/es unknown
- 1996-02-07 MY MYPI96000448A patent/MY113426A/en unknown
-
1997
- 1997-08-06 FI FI973245A patent/FI113774B/fi not_active IP Right Cessation
- 1997-08-06 NO NO19973624A patent/NO315237B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL117045A (en) | 1999-03-12 |
JPH10513460A (ja) | 1998-12-22 |
MY113426A (en) | 2002-02-28 |
AU4785696A (en) | 1996-08-27 |
KR100412070B1 (ko) | 2004-05-24 |
TW446706B (en) | 2001-07-21 |
ZA96933B (en) | 1997-08-06 |
AU692361B2 (en) | 1998-06-04 |
IL117045A0 (en) | 1996-06-18 |
EP0808316A1 (en) | 1997-11-26 |
KR19980701921A (ko) | 1998-06-25 |
DE69632032D1 (de) | 2004-05-06 |
DE69632032T2 (de) | 2005-03-10 |
NO973624D0 (no) | 1997-08-06 |
EP0808316B1 (en) | 2004-03-31 |
FI973245A0 (fi) | 1997-08-06 |
WO1996024596A1 (en) | 1996-08-15 |
FI113774B (fi) | 2004-06-15 |
NO315237B1 (no) | 2003-08-04 |
US5990123A (en) | 1999-11-23 |
NO973624L (no) | 1997-08-06 |
EP0808316B9 (en) | 2004-12-01 |
ATE263170T1 (de) | 2004-04-15 |
JP4093431B2 (ja) | 2008-06-04 |
FI973245A (fi) | 1997-08-06 |
ES2218582T3 (es) | 2004-11-16 |
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