AR000014A1 - Síntesis de un intermediario para la preparación de 7,7 dióxido de 5,6-dihidro-(s)-4-(etilamino)-(s)-6-metil-4h-tienoÄ2,3bÜtiopiran-2-sulfonamida y compuestos relacionados - Google Patents
Síntesis de un intermediario para la preparación de 7,7 dióxido de 5,6-dihidro-(s)-4-(etilamino)-(s)-6-metil-4h-tienoÄ2,3bÜtiopiran-2-sulfonamida y compuestos relacionadosInfo
- Publication number
- AR000014A1 AR000014A1 AR33628696A AR33628696A AR000014A1 AR 000014 A1 AR000014 A1 AR 000014A1 AR 33628696 A AR33628696 A AR 33628696A AR 33628696 A AR33628696 A AR 33628696A AR 000014 A1 AR000014 A1 AR 000014A1
- Authority
- AR
- Argentina
- Prior art keywords
- synthesis
- sulfonamide
- dihydro
- methyl
- related compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Esta invención concierne a un proceso mejorado para la síntesis de un intermediario para preparar 7,7 dióxido de 5,6 dihidro-(S)-6-metil-4H-tieno[2,3b]tiopiran-2-sulfonamida y compuestos relacionados. El presente proceso reduce el tiempo dereacción para la síntesis del intermediario clave, desde3 a 4 días, hasta alrededor de 2 a 4 horas, reteniendo la alta pureza enantiomérica del producto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/430,214 US5574176A (en) | 1995-04-26 | 1995-04-26 | Synthesis of an intermediate for the preparation of 5,6-dihydro-(s)-4-(ethylamino)-(s)-6-methyl-4h-thieno [2,3-b]thiopyran-2-sulfonamide 7,7-dioxide intermediates and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR000014A1 true AR000014A1 (es) | 1997-03-12 |
Family
ID=23706561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR33628696A AR000014A1 (es) | 1995-04-26 | 1996-04-25 | Síntesis de un intermediario para la preparación de 7,7 dióxido de 5,6-dihidro-(s)-4-(etilamino)-(s)-6-metil-4h-tienoÄ2,3bÜtiopiran-2-sulfonamida y compuestos relacionados |
Country Status (10)
Country | Link |
---|---|
US (1) | US5574176A (es) |
EP (1) | EP0824532A1 (es) |
JP (1) | JP3064017B2 (es) |
AR (1) | AR000014A1 (es) |
AU (1) | AU704210B2 (es) |
CA (1) | CA2218654C (es) |
HR (1) | HRP960199B1 (es) |
TW (1) | TW394767B (es) |
WO (1) | WO1996033990A1 (es) |
YU (1) | YU25196A (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0748804B1 (en) * | 1994-12-28 | 2001-03-14 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for producing carboxylic acid derivative |
EP0748803B1 (en) * | 1994-12-28 | 2001-04-04 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for producing carboxylic acid derivative |
US5760249A (en) * | 1995-08-29 | 1998-06-02 | Merck & Co., Inc. | Synthesis of hydroxysulfone and related compounds |
DE602005003672T2 (de) * | 2004-07-09 | 2008-11-20 | Fdc Ltd. | VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON 5,6 -DIHYDRO -4H-4(S)-ETHYLAMIN-6(S)-METHYLTHIENOÄ2,3-bÜ THIOPYRAN-2-SULFONAMID- 7,7 -DIOXID UND SEINEN SALZEN |
CN114891838B (zh) * | 2022-04-29 | 2023-09-08 | 株洲壹诺生物技术有限公司 | 盐酸多佐胺中间体(s)-3-(2-噻吩硫基)-丁酸的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4113968A (en) * | 1974-10-03 | 1978-09-12 | Kuraray Co., Ltd. | Process for preparation of substituted cyclopropane carboxylic acids and esters thereof and intermediates of said acids and esters |
US4797413A (en) * | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
US4968815A (en) * | 1990-04-16 | 1990-11-06 | Merck & Co., Inc. | Synthesis of (S)-3-(thien-2-ylthio)butyric acid analogs |
US4968814A (en) * | 1990-04-18 | 1990-11-06 | Merck & Co., Inc. | (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof |
-
1995
- 1995-04-26 US US08/430,214 patent/US5574176A/en not_active Expired - Fee Related
-
1996
- 1996-04-18 TW TW085104640A patent/TW394767B/zh active
- 1996-04-22 JP JP8532643A patent/JP3064017B2/ja not_active Expired - Fee Related
- 1996-04-22 WO PCT/US1996/005623 patent/WO1996033990A1/en not_active Application Discontinuation
- 1996-04-22 EP EP96911821A patent/EP0824532A1/en not_active Withdrawn
- 1996-04-22 AU AU54885/96A patent/AU704210B2/en not_active Ceased
- 1996-04-22 CA CA002218654A patent/CA2218654C/en not_active Expired - Fee Related
- 1996-04-24 HR HR960199A patent/HRP960199B1/xx not_active IP Right Cessation
- 1996-04-24 YU YU25196A patent/YU25196A/sh unknown
- 1996-04-25 AR AR33628696A patent/AR000014A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW394767B (en) | 2000-06-21 |
EP0824532A1 (en) | 1998-02-25 |
AU704210B2 (en) | 1999-04-15 |
AU5488596A (en) | 1996-11-18 |
CA2218654C (en) | 2002-09-17 |
US5574176A (en) | 1996-11-12 |
WO1996033990A1 (en) | 1996-10-31 |
YU25196A (sh) | 1999-03-04 |
HRP960199A2 (en) | 1998-02-28 |
CA2218654A1 (en) | 1996-10-31 |
HRP960199B1 (en) | 2002-02-28 |
JPH10507774A (ja) | 1998-07-28 |
JP3064017B2 (ja) | 2000-07-12 |
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