AP832A - 3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues. - Google Patents

3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues. Download PDF

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Publication number
AP832A
AP832A APAP/P/1991/000305A AP9100305A AP832A AP 832 A AP832 A AP 832A AP 9100305 A AP9100305 A AP 9100305A AP 832 A AP832 A AP 832A
Authority
AP
ARIPO
Prior art keywords
carboxylate
tetrahydrofuran
ceph
compound
aminothiazol
Prior art date
Application number
APAP/P/1991/000305A
Other languages
English (en)
Other versions
AP9100305A0 (en
Inventor
John Hargreaves Bateson
Stephen Christopher Martin Fell
George Burton
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016189A external-priority patent/GB9016189D0/en
Priority claimed from GB919109540A external-priority patent/GB9109540D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of AP9100305A0 publication Critical patent/AP9100305A0/xx
Application granted granted Critical
Publication of AP832A publication Critical patent/AP832A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
APAP/P/1991/000305A 1990-07-24 1991-07-22 3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues. AP832A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016189A GB9016189D0 (en) 1990-07-24 1990-07-24 Novel compounds
GB919109540A GB9109540D0 (en) 1991-05-02 1991-05-02 Novel compounds

Publications (2)

Publication Number Publication Date
AP9100305A0 AP9100305A0 (en) 1991-07-31
AP832A true AP832A (en) 2000-05-03

Family

ID=26297372

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000305A AP832A (en) 1990-07-24 1991-07-22 3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues.

Country Status (26)

Country Link
EP (2) EP0540609B1 (fr)
JP (2) JPH05509089A (fr)
KR (1) KR100189075B1 (fr)
CN (2) CN1061046C (fr)
AP (1) AP832A (fr)
AT (1) ATE185567T1 (fr)
AU (1) AU648329B2 (fr)
CA (2) CA2087967C (fr)
CZ (1) CZ6493A3 (fr)
DE (2) DE122006000065I2 (fr)
DK (1) DK0540609T3 (fr)
ES (1) ES2137162T3 (fr)
FI (1) FI930270A (fr)
GR (1) GR3031711T3 (fr)
HU (1) HUT63628A (fr)
IE (1) IE912569A1 (fr)
IL (1) IL98909A0 (fr)
LU (1) LU91290I2 (fr)
MX (1) MX9100317A (fr)
MY (1) MY106399A (fr)
NL (1) NL300249I1 (fr)
NO (1) NO930226L (fr)
NZ (1) NZ239061A (fr)
PT (1) PT98426A (fr)
WO (2) WO1992001695A1 (fr)
YU (1) YU129691A (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125645D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compounds
EP0624160B1 (fr) * 1992-01-22 2001-10-31 Pfizer Inc. Derives de 2-isocephem et d'oxacephem, procedes de preparation, les intermediaires de ceux-ci et leur utilisation comme agents antibacteriens
GB9212609D0 (en) * 1992-06-13 1992-07-29 Smithkline Beecham Plc Novel compounds
GB9213567D0 (en) * 1992-06-26 1992-08-12 Smithkline Beecham Plc Novel compounds
GB9424847D0 (en) * 1994-12-09 1995-02-08 Smithkline Beecham Plc Novel process
GB2300856A (en) * 1995-05-16 1996-11-20 Pfizer Ltd Beta-lactam preparation
AU4398297A (en) * 1996-10-02 1998-04-24 Daiichi Pharmaceutical Co., Ltd. Method for esterifying carboxylic compounds
FR2776292B1 (fr) 1998-03-20 2004-09-10 Oncopharm Cephalotaxanes porteurs de chaine laterale et leur procede de synthese
GB0019124D0 (en) 2000-08-03 2000-09-27 Pfizer Novel process
HUP0400642A3 (en) * 2000-12-04 2010-03-29 Pfizer Prod Inc Coupling process and intermediates useful for preparing cephalosphorins
ATE319719T1 (de) * 2000-12-04 2006-03-15 Pfizer Prod Inc Verfahren und esterderivate zur herstellung von cephalosphorinen
US7378408B2 (en) * 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
KR100710555B1 (ko) 2001-12-04 2007-04-24 에스케이 주식회사 광학적으로 순수한 (ｒ)-폼 또는 (ｓ)-폼의테트라히드로퓨라닐 케톤의 제조방법
MX356509B (es) 2011-12-22 2018-05-30 Alios Biopharma Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9422323B2 (en) 2012-05-25 2016-08-23 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
PT2935303T (pt) 2012-12-21 2021-04-30 Alios Biopharma Inc 4'-fluoro-nucleósidos, 4'-fluoro-nucleótidos e seus análogos para o tratamento de hcv
CN105254648B (zh) * 2015-11-13 2018-04-03 广东温氏大华农生物科技有限公司 一种头孢维星及其钠盐的合成方法
GB2575261B (en) 2018-07-02 2022-03-09 Norbrook Lab Ltd Intermediates in the synthesis of C3-substituted cephalosporins
JP2021534196A (ja) 2018-08-23 2021-12-09 シージェン インコーポレイテッド 抗ｔｉｇｉｔ抗体
IL293592A (en) 2019-12-06 2022-08-01 Vertex Pharma Transduced tetrahydrofurans as sodium channel modulators
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
CN111620893B (zh) * 2020-06-08 2021-12-14 重庆医药高等专科学校 C-3位四氢呋喃取代的头孢菌素-铁载体耦合物及其制备方法和应用
US11697666B2 (en) 2021-04-16 2023-07-11 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
AU2022284886A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2300009A1 (de) * 1971-12-31 1973-07-12 Roussel Uclaf Verfahren zur herstellung neuer cephalosporinderivate sowie die erhaltenen produkte
GB1385831A (en) * 1972-05-05 1975-03-05 Hoechst Ag Acylamino-cephem-carboxylic acids and process for their preparation
EP0075805A1 (fr) * 1981-09-18 1983-04-06 Kyowa Hakko Kogyo Co., Ltd Composé beta-lactame et une composition pharmaceutique le contenant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2197573A1 (en) * 1972-09-07 1974-03-29 Roussel Uclaf 7-substd-phenylacetamido-cephalosporin derivs - - antibiotics active against streptococci and staphylococci
BE791161A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Procede pour la preparation d'analogues des cephalosporines
BE791160A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Nouveaux cephemes substitues
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
DE69032681T2 (de) * 1989-03-30 1999-02-25 Pfizer Cephalosporine und ihre Homologen, Verfahren zu ihrer Herstellung und pharmazeutische Präparate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2300009A1 (de) * 1971-12-31 1973-07-12 Roussel Uclaf Verfahren zur herstellung neuer cephalosporinderivate sowie die erhaltenen produkte
GB1385831A (en) * 1972-05-05 1975-03-05 Hoechst Ag Acylamino-cephem-carboxylic acids and process for their preparation
EP0075805A1 (fr) * 1981-09-18 1983-04-06 Kyowa Hakko Kogyo Co., Ltd Composé beta-lactame et une composition pharmaceutique le contenant

Also Published As

Publication number Publication date
NL300249I2 (en) 2007-02-01
NO930226D0 (no) 1993-01-22
CA2359744A1 (fr) 1992-02-06
DE69131714T2 (de) 2000-02-24
DK0540609T3 (da) 1999-12-27
FI930270A0 (fi) 1993-01-22
DE122006000065I1 (de) 2007-03-01
EP0540606A1 (fr) 1993-05-12
CZ6493A3 (en) 1994-04-13
WO1992001695A1 (fr) 1992-02-06
IL98909A0 (en) 1992-07-15
ES2137162T3 (es) 1999-12-16
EP0540609B1 (fr) 1999-10-13
LU91290I2 (fr) 2007-01-22
HUT63628A (en) 1993-09-28
CN1223859A (zh) 1999-07-28
JPH05509089A (ja) 1993-12-16
CA2087967A1 (fr) 1992-01-25
PT98426A (pt) 1992-05-29
NO930226L (no) 1993-03-23
IE912569A1 (en) 1992-01-29
MY106399A (en) 1995-05-30
JP2851428B2 (ja) 1999-01-27
GR3031711T3 (en) 2000-02-29
MX9100317A (es) 1992-02-28
ATE185567T1 (de) 1999-10-15
AU648329B2 (en) 1994-04-21
NZ239061A (en) 1993-11-25
CN1061046C (zh) 2001-01-24
YU129691A (sh) 1994-01-20
AU8222491A (en) 1992-02-18
DE69131714D1 (de) 1999-11-18
KR100189075B1 (ko) 1999-06-01
KR930701456A (ko) 1993-06-11
NL300249I1 (nl) 2007-02-01
FI930270A (fi) 1993-03-22
WO1992001696A1 (fr) 1992-02-06
HU9300177D0 (en) 1993-04-28
EP0540609A1 (fr) 1993-05-12
CN1060469A (zh) 1992-04-22
AP9100305A0 (en) 1991-07-31
CN1111410C (zh) 2003-06-18
JPH05509305A (ja) 1993-12-22
CA2087967C (fr) 2002-09-10
CA2359744C (fr) 2007-02-13
DE122006000065I2 (de) 2007-09-13

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