AP435A - Substituted azolone derivatives. - Google Patents
Substituted azolone derivatives. Download PDFInfo
- Publication number
- AP435A AP435A APAP/P/1994/000622A AP9400622A AP435A AP 435 A AP435 A AP 435A AP 9400622 A AP9400622 A AP 9400622A AP 435 A AP435 A AP 435A
- Authority
- AP
- ARIPO
- Prior art keywords
- formula
- piperazinyl
- dihydro
- pyridinyl
- triazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93200474 | 1993-02-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9400622A0 AP9400622A0 (en) | 1994-04-30 |
| AP435A true AP435A (en) | 1995-11-17 |
Family
ID=8213653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1994/000622A AP435A (en) | 1993-02-19 | 1994-02-18 | Substituted azolone derivatives. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5650411A (en, 2012) |
| EP (1) | EP0684821A1 (en, 2012) |
| JP (1) | JPH08506821A (en, 2012) |
| CN (1) | CN1118138A (en, 2012) |
| AP (1) | AP435A (en, 2012) |
| AU (1) | AU675508B2 (en, 2012) |
| CA (1) | CA2155830A1 (en, 2012) |
| FI (1) | FI953899A0 (en, 2012) |
| HU (1) | HUT73662A (en, 2012) |
| IL (1) | IL108703A (en, 2012) |
| LT (1) | LT3214B (en, 2012) |
| MX (1) | MX9401294A (en, 2012) |
| NO (1) | NO953254L (en, 2012) |
| NZ (1) | NZ261854A (en, 2012) |
| PL (1) | PL174836B1 (en, 2012) |
| RU (1) | RU2128659C1 (en, 2012) |
| TW (1) | TW279864B (en, 2012) |
| WO (1) | WO1994018978A1 (en, 2012) |
| ZA (1) | ZA941137B (en, 2012) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703236A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| WO1995027704A1 (en) * | 1994-04-06 | 1995-10-19 | Janssen Pharmaceutica N.V. | Anti-helicobacter ester and carbamate derivatives of azolones |
| US5639754A (en) * | 1994-07-12 | 1997-06-17 | Janssen Pharmaceutica N.V. | Urea and thiourea derivatives of azolones |
| US5637592A (en) * | 1994-07-12 | 1997-06-10 | Janssen Pharmaceutica N.V. | Acyl derivatives of azolones |
| US5607932A (en) * | 1994-07-12 | 1997-03-04 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives of azolones |
| CA2160423A1 (en) * | 1994-11-02 | 1996-05-03 | Hemant N. Joshi | Salts of nefazodone having improved dissolution rates |
| GB9524754D0 (en) * | 1995-12-04 | 1996-04-24 | Symmetricom Inc | Mobile position determination |
| US6432947B1 (en) * | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
| DE69826883T2 (de) | 1997-10-27 | 2005-02-03 | Neurosearch A/S | Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren |
| RU2145975C1 (ru) * | 1999-07-19 | 2000-02-27 | Тверская медакадемия | Способ культивирования helicobacter pylori |
| US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
| US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
| US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
| US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
| US6369087B1 (en) * | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
| US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
| US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
| US8013156B2 (en) * | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| CN105622463B (zh) | 2006-12-26 | 2019-02-22 | 兰休斯医疗成像公司 | 用于使心脏神经支配成像的配体 |
| CN102234267A (zh) * | 2010-04-21 | 2011-11-09 | 中国科学院上海药物研究所 | 新型三氮唑类抗真菌化合物、其药物组合物及其制备方法和用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0228125A1 (en) * | 1985-12-23 | 1987-07-08 | Janssen Pharmaceutica N.V. | Novel derivatives of [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| EP0331232A2 (en) * | 1988-02-29 | 1989-09-06 | Janssen Pharmaceutica N.V. | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT311956B (de) * | 1971-06-07 | 1973-12-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Phenylimidazolidinonderivate und ihrer Salze |
| AR208414A1 (es) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2) |
| US4724239A (en) * | 1985-09-16 | 1988-02-09 | Morgan Lee R | Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine |
| US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| CA2076257A1 (en) * | 1991-09-13 | 1993-03-14 | Jan Heeres | 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives |
-
1994
- 1994-02-02 TW TW083100854A patent/TW279864B/zh active
- 1994-02-09 EP EP94907534A patent/EP0684821A1/en not_active Withdrawn
- 1994-02-09 CA CA002155830A patent/CA2155830A1/en not_active Abandoned
- 1994-02-09 AU AU61081/94A patent/AU675508B2/en not_active Ceased
- 1994-02-09 US US08/491,960 patent/US5650411A/en not_active Expired - Fee Related
- 1994-02-09 WO PCT/EP1994/000380 patent/WO1994018978A1/en not_active Application Discontinuation
- 1994-02-09 JP JP6518613A patent/JPH08506821A/ja active Pending
- 1994-02-09 NZ NZ261854A patent/NZ261854A/en unknown
- 1994-02-09 CN CN94191221A patent/CN1118138A/zh active Pending
- 1994-02-09 PL PL94310348A patent/PL174836B1/pl unknown
- 1994-02-09 RU RU95122796A patent/RU2128659C1/ru active
- 1994-02-09 HU HU9501923A patent/HUT73662A/hu unknown
- 1994-02-18 MX MX9401294A patent/MX9401294A/es unknown
- 1994-02-18 LT LTIP1874A patent/LT3214B/lt not_active IP Right Cessation
- 1994-02-18 AP APAP/P/1994/000622A patent/AP435A/en active
- 1994-02-18 IL IL108703A patent/IL108703A/en not_active IP Right Cessation
- 1994-02-18 ZA ZA941137A patent/ZA941137B/xx unknown
-
1995
- 1995-08-18 FI FI953899A patent/FI953899A0/fi unknown
- 1995-08-18 NO NO953254A patent/NO953254L/no unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0228125A1 (en) * | 1985-12-23 | 1987-07-08 | Janssen Pharmaceutica N.V. | Novel derivatives of [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| EP0331232A2 (en) * | 1988-02-29 | 1989-09-06 | Janssen Pharmaceutica N.V. | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1118138A (zh) | 1996-03-06 |
| LTIP1874A (en) | 1994-09-25 |
| HUT73662A (en) | 1996-09-30 |
| WO1994018978A1 (en) | 1994-09-01 |
| HU9501923D0 (en) | 1995-09-28 |
| TW279864B (en, 2012) | 1996-07-01 |
| PL174836B1 (pl) | 1998-09-30 |
| LT3214B (en) | 1995-04-25 |
| AU6108194A (en) | 1994-09-14 |
| IL108703A (en) | 1998-01-04 |
| JPH08506821A (ja) | 1996-07-23 |
| PL310348A1 (en) | 1995-12-11 |
| FI953899A7 (fi) | 1995-08-18 |
| EP0684821A1 (en) | 1995-12-06 |
| NO953254L (no) | 1995-09-11 |
| CA2155830A1 (en) | 1994-09-01 |
| MX9401294A (es) | 1994-08-31 |
| NZ261854A (en) | 1997-04-24 |
| FI953899A0 (fi) | 1995-08-18 |
| NO953254D0 (no) | 1995-08-18 |
| AU675508B2 (en) | 1997-02-06 |
| ZA941137B (en) | 1995-10-25 |
| IL108703A0 (en) | 1994-05-30 |
| AP9400622A0 (en) | 1994-04-30 |
| RU2128659C1 (ru) | 1999-04-10 |
| US5650411A (en) | 1997-07-22 |
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