AP333A - Phenyl-substituted pyridyl aliphatic compounds for treating leukotriene-related diseases. - Google Patents

Phenyl-substituted pyridyl aliphatic compounds for treating leukotriene-related diseases. Download PDF

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Publication number
AP333A
AP333A APAP/P/1992/000428A AP9200428A AP333A AP 333 A AP333 A AP 333A AP 9200428 A AP9200428 A AP 9200428A AP 333 A AP333 A AP 333A
Authority
AP
ARIPO
Prior art keywords
methoxyphenyl
carboxyethenyl
phenyl
thia
ethyl
Prior art date
Application number
APAP/P/1992/000428A
Other languages
English (en)
Other versions
AP9200428A0 (en
Inventor
Pamela Anne Chambers
Robert A Daines
Dalia R Jakas
William D Kingsbury
Israel Pendrak (Nmi)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AP9200428A0 publication Critical patent/AP9200428A0/xx
Application granted granted Critical
Publication of AP333A publication Critical patent/AP333A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
APAP/P/1992/000428A 1991-09-19 1992-09-17 Phenyl-substituted pyridyl aliphatic compounds for treating leukotriene-related diseases. AP333A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76271091A 1991-09-19 1991-09-19
US79093191A 1991-11-12 1991-11-12
US80959391A 1991-12-18 1991-12-18
US93286992A 1992-08-20 1992-08-20
CN93103596A CN1092409A (zh) 1991-09-19 1993-03-19 用于治疗白三烯有关的疾病的化合物

Publications (2)

Publication Number Publication Date
AP9200428A0 AP9200428A0 (en) 1992-10-31
AP333A true AP333A (en) 1994-04-25

Family

ID=36809157

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000428A AP333A (en) 1991-09-19 1992-09-17 Phenyl-substituted pyridyl aliphatic compounds for treating leukotriene-related diseases.

Country Status (12)

Country Link
EP (1) EP0604529A1 (zh)
JP (1) JPH06510786A (zh)
CN (1) CN1092409A (zh)
AP (1) AP333A (zh)
AU (1) AU2573592A (zh)
CA (1) CA2119467A1 (zh)
IL (1) IL103205A0 (zh)
MA (1) MA22649A1 (zh)
MX (1) MX9205358A (zh)
NZ (1) NZ244371A (zh)
PT (1) PT100881A (zh)
WO (1) WO1993006085A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3181917B2 (ja) * 1992-06-30 2001-07-03 スミスクライン・ビーチャム・コーポレイション フェニルチオメチルピリジニルアルケノアート類の製造方法
GB9313145D0 (en) * 1993-06-25 1993-08-11 Smithkline Beecham Plc Process
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
EP0812194B1 (en) * 1995-03-02 2000-08-16 Smithkline Beecham Corporation Use of substituted pyridine compounds for treating atopic dermatitis and contact dermatitis
GB9508137D0 (en) * 1995-04-21 1995-06-07 Smithkline Beecham Plc Formulation
JP2000504336A (ja) 1996-02-02 2000-04-11 ゼネカ・リミテッド 薬学製剤として有用なヘテロ環式化合物
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
US5929096A (en) * 1996-02-29 1999-07-27 Smithkline Beecham Corporation Method for treating atopic dermatitis and contact dermatitis
KR20000029984A (ko) * 1996-08-14 2000-05-25 사라 엔 람베쓰 치환된피리미딘유도체및이의약학적용도
AU4557397A (en) * 1996-09-26 1998-04-17 Novartis Ag Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
DE69815509T2 (de) 1997-02-13 2004-05-13 Astrazeneca Ab Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056619A (en) * 1975-09-08 1977-11-01 Warner-Lambert Company 1-Substituted-2-(2-pyridinyl)ethanone N-oxides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1322004C (en) * 1987-11-25 1993-09-07 Merck Frosst Canada Incorporated Pyridyl styrene dialkanoic acids
HUT64747A (en) * 1990-06-07 1994-02-28 Smithkline Beecham Corp Process for producing benzoic acid derivatives and pharmaceutical preparatives containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056619A (en) * 1975-09-08 1977-11-01 Warner-Lambert Company 1-Substituted-2-(2-pyridinyl)ethanone N-oxides

Also Published As

Publication number Publication date
AU2573592A (en) 1993-04-27
JPH06510786A (ja) 1994-12-01
PT100881A (pt) 1993-10-29
AP9200428A0 (en) 1992-10-31
IL103205A0 (en) 1993-02-21
MA22649A1 (fr) 1993-04-01
NZ244371A (en) 1995-11-27
WO1993006085A1 (en) 1993-04-01
CA2119467A1 (en) 1993-04-01
MX9205358A (es) 1993-07-01
CN1092409A (zh) 1994-09-21
EP0604529A1 (en) 1994-07-06

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