AP3280A - Fused pyrimidine-dione derivatives as TRPA1 modulators - Google Patents
Fused pyrimidine-dione derivatives as TRPA1 modulatorsInfo
- Publication number
- AP3280A AP3280A AP2011005887A AP2011005887A AP3280A AP 3280 A AP3280 A AP 3280A AP 2011005887 A AP2011005887 A AP 2011005887A AP 2011005887 A AP2011005887 A AP 2011005887A AP 3280 A AP3280 A AP 3280A
- Authority
- AP
- ARIPO
- Prior art keywords
- dione derivatives
- fused pyrimidine
- trpa1 modulators
- trpa1
- modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN665MU2009 | 2009-03-23 | ||
US17135509P | 2009-04-21 | 2009-04-21 | |
IN2212MU2009 | 2009-09-23 | ||
IN2211MU2009 | 2009-09-23 | ||
US25194409P | 2009-10-15 | 2009-10-15 | |
US25326309P | 2009-10-20 | 2009-10-20 | |
IN2891MU2009 | 2009-12-15 | ||
IN2892MU2009 | 2009-12-15 | ||
US29446310P | 2010-01-12 | 2010-01-12 | |
US30024110P | 2010-02-01 | 2010-02-01 | |
PCT/IB2010/000553 WO2010109287A1 (en) | 2009-03-23 | 2010-03-17 | Fused pyrimidine-dione derivatives as trpa1 modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
AP2011005887A0 AP2011005887A0 (en) | 2011-10-31 |
AP3280A true AP3280A (en) | 2015-05-31 |
Family
ID=42780198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2011005887A AP3280A (en) | 2009-03-23 | 2010-03-17 | Fused pyrimidine-dione derivatives as TRPA1 modulators |
Country Status (24)
Country | Link |
---|---|
US (1) | US9000159B2 (de) |
EP (2) | EP2411393B1 (de) |
JP (1) | JP5657638B2 (de) |
KR (1) | KR20110132575A (de) |
CN (1) | CN102361873B (de) |
AP (1) | AP3280A (de) |
AU (1) | AU2010227245B2 (de) |
BR (1) | BRPI1013559A2 (de) |
CA (1) | CA2756518A1 (de) |
CL (2) | CL2011002315A1 (de) |
DK (1) | DK2411393T3 (de) |
EA (1) | EA023857B1 (de) |
ES (2) | ES2551085T3 (de) |
HK (2) | HK1166075A1 (de) |
IL (1) | IL215178A (de) |
MX (1) | MX2011009824A (de) |
PE (1) | PE20120774A1 (de) |
PL (1) | PL2411393T3 (de) |
PT (1) | PT2411393E (de) |
SG (1) | SG174402A1 (de) |
SI (1) | SI2411393T1 (de) |
UA (1) | UA108069C2 (de) |
WO (1) | WO2010109287A1 (de) |
ZA (1) | ZA201107648B (de) |
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CA2660704A1 (en) | 2006-08-07 | 2008-02-14 | Ironwood Pharmaceuticals, Inc. | Indole compounds |
EA023857B1 (ru) | 2009-03-23 | 2016-07-29 | Гленмарк Фармасеутикалс С.А. | Сочлененные производные пиримидиндионов в качестве модуляторов trpa1 |
EP2655377B1 (de) | 2010-12-20 | 2016-03-30 | Glenmark Pharmaceuticals S.A. | 2-amino-4-arylthiazolverbindungen als trpa1-antagonisten |
AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
EP2520566A1 (de) | 2011-05-06 | 2012-11-07 | Orion Corporation | Neue pharmazeutische Verbindungen |
BR112013032025A2 (pt) | 2011-06-13 | 2016-12-20 | Glenmark Pharmaceutical S A | antagonistas trpa1, compostos ou seus sais farmaceuticamente aceitáveis, métodos para reduzir a quantidade de eosinófilos ou neutrófilos e/ou aumentar fev1 em indivíduo com distúrbio respiratório, para tratar distúrbio respiratório em indivíduo e/ou para identificar antagonista trpa1, usos de quantidade eficaz de antagonista trpa1, e composição farmacêutica para administração por inalação |
WO2012176105A1 (en) | 2011-06-22 | 2012-12-27 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist |
JP2014517062A (ja) | 2011-06-22 | 2014-07-17 | グレンマーク ファーマシューティカルズ, エセ.アー. | TRPA1アンタゴニスト及びβ2アゴニストを含む医薬組成物 |
WO2013014597A1 (en) | 2011-07-25 | 2013-01-31 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising a trpa1 antagonist and a steroid |
TW201311690A (zh) | 2011-08-09 | 2013-03-16 | Hydra Biosciences Inc | 抑制暫態受體電位離子通道trpa1 |
US20140364445A1 (en) | 2011-12-05 | 2014-12-11 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent |
CN104203236A (zh) | 2012-01-17 | 2014-12-10 | 味之素株式会社 | 杂环酰胺衍生物和含有其的药物 |
AU2013273118B2 (en) | 2012-06-08 | 2015-11-05 | Glenmark Pharmaceuticals S.A. | Amides of 2-amino-4-arylthiazole compounds and their salts |
SG11201502150PA (en) | 2012-10-01 | 2015-04-29 | Orion Corp | N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists |
US9394308B2 (en) | 2013-01-18 | 2016-07-19 | Merck Sharp & Dohme Corp. | Inhibiting the transient receptor potential A1 ion channel |
US9532988B2 (en) | 2013-10-15 | 2017-01-03 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition comprising a TRPA1 antagonist and an analgesic agent |
DK3064498T3 (da) * | 2013-10-30 | 2019-10-07 | Shanghai hengrui pharmaceutical co ltd | Pyrazolopyrimidin- eller pyrrolotriazon-derivater, fremgangsmåde til fremstilling af samme, og farmakologiske anvendelser deraf |
CN103755705B (zh) * | 2014-02-17 | 2017-02-15 | 上海佰特因医药科技有限公司 | 一种天然产物四甲基尿酸的全合成方法 |
WO2016023831A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives |
US20190175599A1 (en) | 2014-09-16 | 2019-06-13 | Glemark Pharmaceuticals S.A. | Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain |
CN105001170A (zh) * | 2015-07-13 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 末端腈基取代的三氮唑亚砜类化合物、其制备方法及其用途 |
WO2017060488A1 (en) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
WO2017064068A1 (en) | 2015-10-14 | 2017-04-20 | Almirall, S.A. | New trpa1 antagonists |
CN109983017B (zh) * | 2017-07-28 | 2021-11-12 | 江苏恒瑞医药股份有限公司 | 一种嘧啶酮并杂芳基类衍生物的制备方法及其中间体 |
CN109422749B (zh) * | 2017-08-21 | 2023-01-24 | 重庆医药工业研究院有限责任公司 | 一种抑制单羧酸转运蛋白的嘧啶二酮衍生物 |
US10710994B2 (en) | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
CN108558836A (zh) * | 2018-05-14 | 2018-09-21 | 东南大学 | 一类具有双重作用机制的dpp-4抑制剂及其用途 |
WO2023096915A1 (en) * | 2021-11-24 | 2023-06-01 | Slap Pharmaceuticals Llc | Multicyclic compounds |
WO2023150592A2 (en) * | 2022-02-03 | 2023-08-10 | D.E. Shaw Research, Llc | N3-substituted uracil compounds as trpa1 inhibitors |
AU2023235233A1 (en) * | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
CN114656472B (zh) * | 2022-04-27 | 2023-07-04 | 成都施贝康生物医药科技有限公司 | 吡唑并嘧啶类化合物、异构体或盐及其制备方法和用途 |
CN114656480B (zh) * | 2022-04-27 | 2024-01-26 | 成都施贝康生物医药科技有限公司 | 噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途 |
CN114656473B (zh) * | 2022-04-27 | 2023-09-29 | 成都施贝康生物医药科技有限公司 | 吡咯并嘧啶类化合物、异构体或盐及其制备方法和用途 |
WO2024153028A1 (zh) * | 2023-01-20 | 2024-07-25 | 深圳晶蛋生物医药科技有限公司 | 大环类化合物、其药物组合物及其应用 |
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2010
- 2010-03-17 EA EA201190143A patent/EA023857B1/ru not_active IP Right Cessation
- 2010-03-17 AP AP2011005887A patent/AP3280A/xx active
- 2010-03-17 KR KR1020117022612A patent/KR20110132575A/ko not_active Application Discontinuation
- 2010-03-17 PL PL10755503T patent/PL2411393T3/pl unknown
- 2010-03-17 EP EP10755503.9A patent/EP2411393B1/de not_active Not-in-force
- 2010-03-17 DK DK10755503.9T patent/DK2411393T3/da active
- 2010-03-17 EP EP13005523.9A patent/EP2708538B1/de not_active Not-in-force
- 2010-03-17 BR BRPI1013559A patent/BRPI1013559A2/pt active Search and Examination
- 2010-03-17 AU AU2010227245A patent/AU2010227245B2/en not_active Ceased
- 2010-03-17 ES ES13005523.9T patent/ES2551085T3/es active Active
- 2010-03-17 UA UAA201111147A patent/UA108069C2/uk unknown
- 2010-03-17 PE PE2011001707A patent/PE20120774A1/es not_active Application Discontinuation
- 2010-03-17 PT PT107555039T patent/PT2411393E/pt unknown
- 2010-03-17 ES ES10755503.9T patent/ES2456515T3/es active Active
- 2010-03-17 WO PCT/IB2010/000553 patent/WO2010109287A1/en active Application Filing
- 2010-03-17 CA CA2756518A patent/CA2756518A1/en not_active Abandoned
- 2010-03-17 MX MX2011009824A patent/MX2011009824A/es unknown
- 2010-03-17 CN CN201080013471.6A patent/CN102361873B/zh not_active Expired - Fee Related
- 2010-03-17 SI SI201030523T patent/SI2411393T1/sl unknown
- 2010-03-17 JP JP2012501401A patent/JP5657638B2/ja not_active Expired - Fee Related
- 2010-03-17 SG SG2011066487A patent/SG174402A1/en unknown
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2011
- 2011-09-15 IL IL215178A patent/IL215178A/en not_active IP Right Cessation
- 2011-09-20 CL CL2011002315A patent/CL2011002315A1/es unknown
- 2011-10-19 ZA ZA2011/07648A patent/ZA201107648B/en unknown
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2012
- 2012-07-11 HK HK12106785.2A patent/HK1166075A1/xx not_active IP Right Cessation
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2013
- 2013-11-14 US US14/079,932 patent/US9000159B2/en not_active Expired - Fee Related
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2014
- 2014-06-02 CL CL2014001447A patent/CL2014001447A1/es unknown
- 2014-08-13 HK HK14108296.8A patent/HK1194742A1/xx not_active IP Right Cessation
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