AP2756A - New dihydroindolone compounds, a process for theirpreparation and pharmaceutical compositions containing them - Google Patents

New dihydroindolone compounds, a process for theirpreparation and pharmaceutical compositions containing them

Info

Publication number
AP2756A
AP2756A AP2010005343A AP2010005343A AP2756A AP 2756 A AP2756 A AP 2756A AP 2010005343 A AP2010005343 A AP 2010005343A AP 2010005343 A AP2010005343 A AP 2010005343A AP 2756 A AP2756 A AP 2756A
Authority
AP
ARIPO
Prior art keywords
theirpreparation
pharmaceutical compositions
compositions containing
new
compounds
Prior art date
Application number
AP2010005343A
Other languages
English (en)
Other versions
AP2010005343A0 (en
Inventor
Jean-Claude Ortuno
Alexis Cordi
Jean-Michel Lacoste
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AP2010005343A0 publication Critical patent/AP2010005343A0/en
Application granted granted Critical
Publication of AP2756A publication Critical patent/AP2756A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Computer And Data Communications (AREA)
  • Storage Device Security (AREA)
AP2010005343A 2009-08-04 2010-07-26 New dihydroindolone compounds, a process for theirpreparation and pharmaceutical compositions containing them AP2756A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903839A FR2948940B1 (fr) 2009-08-04 2009-08-04 Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
AP2010005343A0 AP2010005343A0 (en) 2010-08-31
AP2756A true AP2756A (en) 2013-09-30

Family

ID=41796204

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2010005343A AP2756A (en) 2009-08-04 2010-07-26 New dihydroindolone compounds, a process for theirpreparation and pharmaceutical compositions containing them

Country Status (43)

Country Link
US (3) US8133889B2 (ja)
EP (1) EP2281822B1 (ja)
JP (2) JP5475588B2 (ja)
KR (1) KR101309101B1 (ja)
CN (1) CN101987848B (ja)
AP (1) AP2756A (ja)
AR (1) AR077510A1 (ja)
AU (1) AU2010203305B2 (ja)
BR (1) BRPI1003241A2 (ja)
CA (1) CA2710224C (ja)
CL (1) CL2010000804A1 (ja)
CO (1) CO6320143A1 (ja)
CU (1) CU23921B1 (ja)
CY (1) CY1113914T1 (ja)
DK (1) DK2281822T3 (ja)
EA (1) EA019481B1 (ja)
EC (1) ECSP10010380A (ja)
ES (1) ES2403227T3 (ja)
FR (1) FR2948940B1 (ja)
GE (1) GEP20125548B (ja)
HK (1) HK1155742A1 (ja)
HN (1) HN2010001537A (ja)
HR (1) HRP20130327T1 (ja)
IL (1) IL207183A (ja)
JO (1) JO2808B1 (ja)
MA (1) MA32184B1 (ja)
ME (1) ME01491B (ja)
MX (1) MX2010008557A (ja)
MY (1) MY183326A (ja)
NI (1) NI201000134A (ja)
NZ (1) NZ586993A (ja)
PE (1) PE20110206A1 (ja)
PL (1) PL2281822T3 (ja)
PT (1) PT2281822E (ja)
RS (1) RS52701B (ja)
SA (1) SA110310634B1 (ja)
SG (1) SG168499A1 (ja)
SI (1) SI2281822T1 (ja)
TW (1) TWI408138B (ja)
UA (1) UA105357C2 (ja)
UY (1) UY32801A (ja)
WO (1) WO2011015728A1 (ja)
ZA (1) ZA201005424B (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2948940B1 (fr) 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10245270B2 (en) * 2013-07-12 2019-04-02 Les Laboratoires Servier Salt of 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, its preparation, and formulations containing it
FR3008411B1 (fr) * 2013-07-12 2015-07-03 Servier Lab Nouveau sel de la 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, sa preparation, et les formulations qui le contiennent
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
FR3039401B1 (fr) * 2015-07-31 2018-07-13 Les Laboratoires Servier Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr
US10343991B2 (en) * 2016-11-02 2019-07-09 Council Of Scientific & Industrial Research C5, C6 substituted and/or fused oxindoles as anti-cancer agents and process for preparation thereof
EP3661917B1 (en) 2017-08-04 2022-05-11 Bayer Aktiengesellschaft 6-((3-trifluoromethyl)phenyl)-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
JOP20200024A1 (ar) * 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
CN113845524B (zh) * 2021-10-29 2023-11-07 四川农业大学 一种螺吡咯吲哚酮类化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060814A2 (en) * 2000-02-15 2001-08-23 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0892248A (ja) * 1994-09-26 1996-04-09 Yamanouchi Pharmaceut Co Ltd インドリノン誘導体
CA2383623A1 (en) * 1998-08-04 2000-02-17 Sugen, Inc. 3-methylidenyl-2-indolinone modulators of protein kinase
DK1157019T3 (da) * 1998-12-17 2003-07-14 Hoffmann La Roche 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2
WO2001000814A2 (en) 1999-06-25 2001-01-04 Universität Zürich Hetero-associating coiled-coil peptides and screenign method therefor
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
MXPA04006271A (es) * 2001-12-27 2004-10-04 Theravance Inc Derivados de indolinona utiles como inhibidores de la proteina cinasa.
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
RU2006117635A (ru) * 2003-10-24 2007-12-10 Шеринг Акциенгезельшафт (De) Производные индолинона и их применение для лечения патологических состояний, таких как злокачественное новообразование
US7378530B2 (en) * 2005-02-22 2008-05-27 Nereus Pharmaceuticals, Inc. Anti-cancer and anti-microbial 5-membered heterocyclic compounds
JP2009522276A (ja) * 2005-12-29 2009-06-11 ザ スクリップス リサーチ インスティテュート インドリノンベースのプロテインキナーゼ阻害剤のアミノ酸誘導体
FR2948940B1 (fr) 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060814A2 (en) * 2000-02-15 2001-08-23 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors

Also Published As

Publication number Publication date
TW201118092A (en) 2011-06-01
MA32184B1 (fr) 2011-04-01
US20110034460A1 (en) 2011-02-10
JP5538580B2 (ja) 2014-07-02
KR20110014116A (ko) 2011-02-10
FR2948940A1 (fr) 2011-02-11
US8653073B2 (en) 2014-02-18
CA2710224A1 (fr) 2011-02-04
IL207183A0 (en) 2010-12-30
HRP20130327T1 (hr) 2013-05-31
CU23921B1 (es) 2013-07-31
CU20100157A7 (es) 2012-03-15
UA105357C2 (uk) 2014-05-12
PE20110206A1 (es) 2011-04-09
EA019481B1 (ru) 2014-04-30
JP5475588B2 (ja) 2014-04-16
CL2010000804A1 (es) 2011-08-26
MX2010008557A (es) 2011-02-03
BRPI1003241A2 (pt) 2012-04-10
AU2010203305A1 (en) 2011-02-24
AP2010005343A0 (en) 2010-08-31
AU2010203305B2 (en) 2015-02-05
US20130331380A1 (en) 2013-12-12
IL207183A (en) 2014-01-30
EP2281822B1 (fr) 2013-01-16
RS52701B (en) 2013-08-30
US8541412B2 (en) 2013-09-24
CO6320143A1 (es) 2011-09-20
MY183326A (en) 2021-02-18
JP2011037848A (ja) 2011-02-24
DK2281822T3 (da) 2013-04-22
AR077510A1 (es) 2011-08-31
JP2013116908A (ja) 2013-06-13
CN101987848A (zh) 2011-03-23
NZ586993A (en) 2012-01-12
NI201000134A (es) 2014-02-11
ME01491B (me) 2014-04-20
CA2710224C (fr) 2013-01-08
GEP20125548B (en) 2012-05-25
ES2403227T3 (es) 2013-05-16
PL2281822T3 (pl) 2013-06-28
SA110310634B1 (ar) 2013-11-10
EA201001087A1 (ru) 2011-04-29
WO2011015728A1 (fr) 2011-02-10
HK1155742A1 (en) 2012-05-25
EP2281822A1 (fr) 2011-02-09
PT2281822E (pt) 2013-02-27
ZA201005424B (en) 2011-04-28
CY1113914T1 (el) 2016-07-27
US20120046287A1 (en) 2012-02-23
KR101309101B1 (ko) 2013-09-16
FR2948940B1 (fr) 2011-07-22
UY32801A (es) 2011-01-31
CN101987848B (zh) 2014-06-18
JO2808B1 (en) 2014-09-15
US8133889B2 (en) 2012-03-13
TWI408138B (zh) 2013-09-11
ECSP10010380A (es) 2011-03-31
HN2010001537A (es) 2013-05-06
SG168499A1 (en) 2011-02-28
SI2281822T1 (sl) 2013-04-30

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