AP2408A - Pyridine[3,4-B]pyrazinones. - Google Patents

Pyridine[3,4-B]pyrazinones.

Info

Publication number
AP2408A
AP2408A AP2008004640A AP2008004640A AP2408A AP 2408 A AP2408 A AP 2408A AP 2008004640 A AP2008004640 A AP 2008004640A AP 2008004640 A AP2008004640 A AP 2008004640A AP 2408 A AP2408 A AP 2408A
Authority
AP
ARIPO
Prior art keywords
pyrazinones
pyridine
Prior art date
Application number
AP2008004640A
Other languages
English (en)
Other versions
AP2008004640A0 (en
Inventor
Andrew Simon Bell
David Louis Brown
David Graham Brown
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2008004640A0 publication Critical patent/AP2008004640A0/xx
Application granted granted Critical
Publication of AP2408A publication Critical patent/AP2408A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2008004640A 2006-04-21 2007-04-10 Pyridine[3,4-B]pyrazinones. AP2408A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79397106P 2006-04-21 2006-04-21
PCT/IB2007/001001 WO2007122466A1 (en) 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones

Publications (2)

Publication Number Publication Date
AP2008004640A0 AP2008004640A0 (en) 2008-10-31
AP2408A true AP2408A (en) 2012-05-30

Family

ID=38431249

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004640A AP2408A (en) 2006-04-21 2007-04-10 Pyridine[3,4-B]pyrazinones.

Country Status (41)

Country Link
US (1) US7902195B2 (sl)
EP (1) EP2013208B1 (sl)
JP (1) JP4436892B2 (sl)
KR (1) KR101061328B1 (sl)
CN (1) CN101454320B (sl)
AP (1) AP2408A (sl)
AR (1) AR060525A1 (sl)
AT (1) ATE513831T1 (sl)
AU (1) AU2007242555B2 (sl)
BR (1) BRPI0710658A2 (sl)
CA (1) CA2649775C (sl)
CR (1) CR10327A (sl)
CU (1) CU23777B7 (sl)
CY (1) CY1111739T1 (sl)
DK (1) DK2013208T3 (sl)
DO (1) DOP2007000080A (sl)
EA (1) EA014919B1 (sl)
EC (1) ECSP088803A (sl)
ES (1) ES2366239T3 (sl)
GT (1) GT200700035A (sl)
HR (1) HRP20110539T1 (sl)
IL (1) IL194591A (sl)
MA (1) MA30352B1 (sl)
ME (1) MEP23808A (sl)
MX (1) MX2008012456A (sl)
MY (1) MY148583A (sl)
NL (1) NL2000583C2 (sl)
NO (1) NO20084129L (sl)
NZ (1) NZ571540A (sl)
PA (1) PA8724201A1 (sl)
PE (1) PE20080192A1 (sl)
PL (1) PL2013208T3 (sl)
RS (2) RS20080484A (sl)
SI (1) SI2013208T1 (sl)
SV (1) SV2008003074A (sl)
TN (1) TNSN08408A1 (sl)
TW (1) TWI337609B (sl)
UA (1) UA92637C2 (sl)
UY (1) UY30291A1 (sl)
WO (1) WO2007122466A1 (sl)
ZA (1) ZA200808283B (sl)

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BRPI0908569B8 (pt) * 2008-03-05 2021-05-25 Merck Patent Gmbh estimuladores de secreção de insulina derivados de piridopirazinonas, seu uso, e composição farmacêutica
JPWO2010041711A1 (ja) * 2008-10-09 2012-03-08 杏林製薬株式会社 イソキノリン誘導体及びそれらを有効成分とするpde阻害剤
KR20120091240A (ko) * 2009-10-26 2012-08-17 시그날 파마소티칼 엘엘씨 헤테로아릴 화합물의 합성 및 정제 방법
US20120269898A1 (en) 2010-10-15 2012-10-25 Luiz Belardinelli Compositions and methods of treating pulmonary hypertension
ES2602794T3 (es) 2011-03-31 2017-02-22 Pfizer Inc Piridinonas bicíclicas novedosas
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
EP2751116B1 (en) 2011-08-31 2016-10-12 Pfizer Inc Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
CA2872154C (en) 2012-05-04 2016-08-23 Pfizer Inc. Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2
US9260455B2 (en) 2012-09-20 2016-02-16 Pfizer Inc. Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
EP2931731A1 (en) 2012-12-11 2015-10-21 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
US9403846B2 (en) 2012-12-19 2016-08-02 Pfizer Inc. Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CA2897678A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
MA38333A1 (fr) 2013-02-19 2017-02-28 Pfizer Composés d'azabenzimidazole en tant qu'inhibiteurs d'isozymes pde4 pour le traitement de troubles du snc et d'autres affections
EP3052495B1 (en) 2013-10-04 2019-06-26 Pfizer Inc Novel bicyclic pyridinones as gamma-secretase modulators
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
CN106211770B (zh) 2014-04-01 2018-02-06 辉瑞公司 作为γ‑分泌酶调节剂的色烯和1,1A,2,7B‑四氢环丙烷并[c]色烯吡啶并吡嗪二酮
CN106459088A (zh) 2014-04-10 2017-02-22 辉瑞公司 2‑氨基‑6‑甲基‑4,4a,5,6‑四氢吡喃并[3,4‑d][1,3]噻嗪‑8a(8H)‑基‑1,3‑噻唑‑4‑基酰胺
WO2016012896A1 (en) 2014-07-24 2016-01-28 Pfizer Inc. Pyrazolopyrimidine compounds
SG11201700243YA (en) 2014-08-06 2017-02-27 Pfizer Imidazopyridazine compounds
BR112017015693A2 (pt) 2015-02-03 2018-03-20 Pfizer ciclopropabenzofuranil piridopirazinadionas
DK3310784T3 (da) 2015-06-17 2020-11-09 Pfizer Tricykliske forbindelser og deres anvendelse som phosphodiesterasehæmmere
EP3353183A1 (en) 2015-09-24 2018-08-01 Pfizer Inc N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3]thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl]amides
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
WO2017051303A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
MX379704B (es) 2016-02-23 2025-03-11 Pfizer Compuestos de 6,7-dihidro-5h-pirazolo[5,1-b][1,3]oxazina-2-carboxamida
SG11201811712QA (en) 2016-07-01 2019-01-30 Pfizer 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
PT3642202T (pt) 2017-06-22 2023-02-02 Pfizer Derivados de dihidro-pirrolo-piridina
CN111182898B (zh) * 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
CA3094366A1 (en) 2018-03-23 2019-09-26 Pfizer Inc. Piperazine azaspiro derivatives
WO2022182658A1 (en) 2021-02-23 2022-09-01 Hoth Therapeutics, Inc. Use of aprepitant for treating alzheimer's disease
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors
WO2025145091A1 (en) 2023-12-29 2025-07-03 Pfizer Inc. Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases
WO2025160132A1 (en) * 2024-01-23 2025-07-31 Maplight Therapeutics, Inc. Gpr6 inverse agonists

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US20020147199A1 (en) * 2000-03-14 2002-10-10 Degenhard Marx Process for the treatment of erectile dysfunction and product therefor
EP1364950A1 (en) * 2001-02-26 2003-11-26 Tanabe Seiyaku Co., Ltd. Pyridopyrimidine or naphthyridine derivative
WO2006126082A2 (en) * 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors

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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20020147199A1 (en) * 2000-03-14 2002-10-10 Degenhard Marx Process for the treatment of erectile dysfunction and product therefor
EP1364950A1 (en) * 2001-02-26 2003-11-26 Tanabe Seiyaku Co., Ltd. Pyridopyrimidine or naphthyridine derivative
WO2006126082A2 (en) * 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors

Also Published As

Publication number Publication date
CN101454320B (zh) 2012-12-19
PE20080192A1 (es) 2008-03-01
CN101454320A (zh) 2009-06-10
EA200801998A1 (ru) 2009-04-28
EP2013208A1 (en) 2009-01-14
AR060525A1 (es) 2008-06-25
HRP20110539T1 (hr) 2011-08-31
UY30291A1 (es) 2007-11-30
HK1133875A1 (en) 2010-04-09
DK2013208T3 (da) 2011-08-15
TW200808794A (en) 2008-02-16
CA2649775C (en) 2011-05-31
PL2013208T3 (pl) 2011-10-31
US7902195B2 (en) 2011-03-08
CA2649775A1 (en) 2007-11-01
NL2000583C2 (nl) 2007-12-14
UA92637C2 (en) 2010-11-25
CU23777B7 (es) 2012-02-15
SV2008003074A (es) 2010-01-12
KR20080110930A (ko) 2008-12-19
ATE513831T1 (de) 2011-07-15
MA30352B1 (fr) 2009-04-01
RS51885B (sr) 2012-02-29
IL194591A (en) 2012-07-31
JP2009534368A (ja) 2009-09-24
GT200700035A (es) 2008-02-05
DOP2007000080A (es) 2007-11-15
BRPI0710658A2 (pt) 2011-08-16
AP2008004640A0 (en) 2008-10-31
TNSN08408A1 (fr) 2010-04-14
JP4436892B2 (ja) 2010-03-24
TWI337609B (en) 2011-02-21
CY1111739T1 (el) 2015-10-07
PA8724201A1 (es) 2009-08-26
MY148583A (en) 2013-04-30
CR10327A (es) 2008-10-21
ES2366239T3 (es) 2011-10-18
MEP23808A (en) 2010-06-10
AU2007242555B2 (en) 2010-12-16
NZ571540A (en) 2010-10-29
SI2013208T1 (sl) 2011-09-30
CU20080194A7 (es) 2011-03-21
WO2007122466A1 (en) 2007-11-01
RS20080484A (sr) 2009-07-15
US20070249615A1 (en) 2007-10-25
EA014919B1 (ru) 2011-04-29
NL2000583A1 (nl) 2007-10-23
AU2007242555A1 (en) 2007-11-01
ZA200808283B (en) 2009-11-25
ECSP088803A (es) 2008-11-27
MX2008012456A (es) 2008-10-10
EP2013208B1 (en) 2011-06-22
NO20084129L (no) 2008-10-29
KR101061328B1 (ko) 2011-08-31

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