AP2015008366A0 - 2-Phenyl-5-heterocyclyl-tetrahydro-2H-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders - Google Patents
2-Phenyl-5-heterocyclyl-tetrahydro-2H-pyran-3-amine compounds for use in the treatment of diabetes and its associated disordersInfo
- Publication number
- AP2015008366A0 AP2015008366A0 AP2015008366A AP2015008366A AP2015008366A0 AP 2015008366 A0 AP2015008366 A0 AP 2015008366A0 AP 2015008366 A AP2015008366 A AP 2015008366A AP 2015008366 A AP2015008366 A AP 2015008366A AP 2015008366 A0 AP2015008366 A0 AP 2015008366A0
- Authority
- AP
- ARIPO
- Prior art keywords
- pyran
- heterocyclyl
- tetrahydro
- diabetes
- phenyl
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3030MU2012 | 2012-10-17 | ||
PCT/IN2013/000627 WO2014061031A1 (en) | 2012-10-17 | 2013-10-17 | 2-phenyl-5-heterocyclyl-tetrahydro-2h-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2015008366A0 true AP2015008366A0 (en) | 2015-04-30 |
Family
ID=49917687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2015008366A AP2015008366A0 (en) | 2012-10-17 | 2013-10-17 | 2-Phenyl-5-heterocyclyl-tetrahydro-2H-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders |
Country Status (23)
Country | Link |
---|---|
US (1) | US20150246025A1 (de) |
EP (1) | EP2909199A1 (de) |
JP (1) | JP2016500685A (de) |
KR (1) | KR20150070325A (de) |
CN (1) | CN104736534A (de) |
AP (1) | AP2015008366A0 (de) |
AR (1) | AR093047A1 (de) |
AU (1) | AU2013333405A1 (de) |
BR (1) | BR112015008717A2 (de) |
CA (1) | CA2886710A1 (de) |
CL (1) | CL2015000976A1 (de) |
CO (1) | CO7350641A2 (de) |
EA (1) | EA201590735A1 (de) |
HK (1) | HK1207860A1 (de) |
IL (1) | IL238027A0 (de) |
MA (1) | MA38079A1 (de) |
MX (1) | MX2015004846A (de) |
PE (1) | PE20150902A1 (de) |
PH (1) | PH12015500860A1 (de) |
SG (1) | SG11201502653VA (de) |
TW (1) | TWI500613B (de) |
WO (1) | WO2014061031A1 (de) |
ZA (1) | ZA201502290B (de) |
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CN105085528A (zh) * | 2014-05-15 | 2015-11-25 | 成都贝斯凯瑞生物科技有限公司 | 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物 |
JP6574474B2 (ja) * | 2014-07-21 | 2019-09-11 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | キラルジペプチジルペプチダーゼ−iv阻害剤の製造方法 |
CN106478631B (zh) * | 2015-08-24 | 2019-04-05 | 四川科伦药物研究院有限公司 | 长效二肽基肽酶-iv抑制剂、用途及其中间体的制备方法 |
TWI682933B (zh) * | 2015-08-27 | 2020-01-21 | 大陸商四川海思科製藥有限公司 | 三員稠合環取代的胺基六員環類衍生物及其在醫藥上的應用 |
CN105198847B (zh) * | 2015-10-28 | 2017-05-17 | 四川凯科医药科技有限公司 | 一种化合物的制备方法 |
CN106146405B (zh) * | 2016-06-22 | 2018-11-30 | 湖北生物医药产业技术研究院有限公司 | 药物杂质中间体及其制备方法和用途 |
RS60209B1 (sr) * | 2017-03-20 | 2020-06-30 | Forma Therapeutics Inc | Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr) |
WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
US20220031671A1 (en) | 2018-09-19 | 2022-02-03 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
CN109928971B (zh) * | 2019-03-14 | 2024-01-16 | 广东东阳光药业股份有限公司 | 芳基取代的氨基四氢吡喃类化合物及其用途 |
CN115304605B (zh) * | 2022-01-21 | 2023-10-03 | 陕西国际商贸学院 | 具有抗肿瘤活性的氧杂环丁烷衍生物及其制备方法和应用 |
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WO2008060488A1 (en) | 2006-11-14 | 2008-05-22 | Merck & Co., Inc. | Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
EP2190428A4 (de) * | 2007-08-21 | 2012-02-29 | Merck Sharp & Dohme | Heterocyclische verbindungen als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes |
CN101468988A (zh) | 2007-12-26 | 2009-07-01 | 上海恒瑞医药有限公司 | 哌嗪类衍生物,其制备方法及其在医药上的应用 |
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CN102260265B (zh) * | 2010-05-24 | 2015-09-02 | 上海阳帆医药科技有限公司 | 六氢吡咯[3,4-b]吡咯衍生物、其制备方法及其用途 |
WO2012101654A2 (en) | 2011-01-25 | 2012-08-02 | Sphaera Pharma Pvt. Ltd | Novel triazine compounds |
EP2680851B1 (de) | 2011-03-03 | 2016-08-17 | Merck Sharp & Dohme Corp. | Kondensierte bicyclische heterocyclen als dipeptidylpeptidase-iv-hemmer |
KR20140034861A (ko) | 2011-06-29 | 2014-03-20 | 머크 샤프 앤드 돔 코포레이션 | 디펩티딜 펩티다제-iv 억제제의 신규한 결정질 형태 |
US9073930B2 (en) | 2012-02-17 | 2015-07-07 | Merck Sharp & Dohme | Dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
-
2013
- 2013-10-16 TW TW102137331A patent/TWI500613B/zh not_active IP Right Cessation
- 2013-10-17 AU AU2013333405A patent/AU2013333405A1/en not_active Abandoned
- 2013-10-17 EP EP13817742.3A patent/EP2909199A1/de not_active Withdrawn
- 2013-10-17 US US14/436,504 patent/US20150246025A1/en not_active Abandoned
- 2013-10-17 MA MA38079A patent/MA38079A1/fr unknown
- 2013-10-17 CN CN201380054443.2A patent/CN104736534A/zh active Pending
- 2013-10-17 AR ARP130103771A patent/AR093047A1/es unknown
- 2013-10-17 WO PCT/IN2013/000627 patent/WO2014061031A1/en active Application Filing
- 2013-10-17 AP AP2015008366A patent/AP2015008366A0/xx unknown
- 2013-10-17 SG SG11201502653VA patent/SG11201502653VA/en unknown
- 2013-10-17 MX MX2015004846A patent/MX2015004846A/es unknown
- 2013-10-17 EA EA201590735A patent/EA201590735A1/ru unknown
- 2013-10-17 BR BR112015008717A patent/BR112015008717A2/pt not_active IP Right Cessation
- 2013-10-17 KR KR1020157012688A patent/KR20150070325A/ko not_active Application Discontinuation
- 2013-10-17 JP JP2015537421A patent/JP2016500685A/ja not_active Ceased
- 2013-10-17 PE PE2015000501A patent/PE20150902A1/es not_active Application Discontinuation
- 2013-10-17 CA CA2886710A patent/CA2886710A1/en not_active Abandoned
-
2015
- 2015-03-30 IL IL238027A patent/IL238027A0/en unknown
- 2015-04-07 ZA ZA2015/02290A patent/ZA201502290B/en unknown
- 2015-04-16 CO CO15085319A patent/CO7350641A2/es unknown
- 2015-04-16 CL CL2015000976A patent/CL2015000976A1/es unknown
- 2015-04-17 PH PH12015500860A patent/PH12015500860A1/en unknown
- 2015-08-31 HK HK15108497.4A patent/HK1207860A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
TW201429960A (zh) | 2014-08-01 |
CL2015000976A1 (es) | 2015-12-18 |
CO7350641A2 (es) | 2015-08-10 |
ZA201502290B (en) | 2016-01-27 |
EA201590735A1 (ru) | 2016-04-29 |
WO2014061031A1 (en) | 2014-04-24 |
IL238027A0 (en) | 2015-05-31 |
US20150246025A1 (en) | 2015-09-03 |
BR112015008717A2 (pt) | 2017-07-04 |
KR20150070325A (ko) | 2015-06-24 |
CA2886710A1 (en) | 2014-04-24 |
MX2015004846A (es) | 2015-07-21 |
TWI500613B (zh) | 2015-09-21 |
AU2013333405A1 (en) | 2015-05-07 |
AR093047A1 (es) | 2015-05-13 |
EP2909199A1 (de) | 2015-08-26 |
HK1207860A1 (en) | 2016-02-12 |
PE20150902A1 (es) | 2015-06-25 |
SG11201502653VA (en) | 2015-05-28 |
JP2016500685A (ja) | 2016-01-14 |
CN104736534A (zh) | 2015-06-24 |
PH12015500860A1 (en) | 2015-06-22 |
MA38079A1 (fr) | 2016-09-30 |
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