AP2008004463A0 - pyrazole derivatives and their medical use - Google Patents

pyrazole derivatives and their medical use

Info

Publication number
AP2008004463A0
AP2008004463A0 AP2008004463A AP2008004463A AP2008004463A0 AP 2008004463 A0 AP2008004463 A0 AP 2008004463A0 AP 2008004463 A AP2008004463 A AP 2008004463A AP 2008004463 A AP2008004463 A AP 2008004463A AP 2008004463 A0 AP2008004463 A0 AP 2008004463A0
Authority
AP
ARIPO
Prior art keywords
medical use
pyrazole derivatives
pyrazole
derivatives
medical
Prior art date
Application number
AP2008004463A
Other languages
English (en)
Inventor
Paul Anthony Bradlley
Kevin Neil Dack
Patrik Stephen Et Al Johnson
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AP2008004463A0 publication Critical patent/AP2008004463A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AP2008004463A 2005-11-08 2006-10-26 pyrazole derivatives and their medical use AP2008004463A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73509105P 2005-11-08 2005-11-08
PCT/IB2006/003080 WO2007054770A2 (en) 2005-11-08 2006-10-26 Pyrazole derivatives and their medical use

Publications (1)

Publication Number Publication Date
AP2008004463A0 true AP2008004463A0 (en) 2008-06-30

Family

ID=37909834

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004463A AP2008004463A0 (en) 2005-11-08 2006-10-26 pyrazole derivatives and their medical use

Country Status (35)

Country Link
US (2) US7309712B2 (da)
EP (1) EP1948615B1 (da)
JP (1) JP4234786B1 (da)
KR (1) KR100997595B1 (da)
CN (1) CN101304974A (da)
AP (1) AP2008004463A0 (da)
AR (1) AR056780A1 (da)
AT (1) ATE537150T1 (da)
AU (1) AU2006313478A1 (da)
BR (1) BRPI0618630A2 (da)
CA (1) CA2628844C (da)
CR (1) CR9959A (da)
CY (1) CY1112286T1 (da)
DK (1) DK1948615T3 (da)
DO (1) DOP2006000245A (da)
EA (1) EA014693B1 (da)
EC (1) ECSP088431A (da)
ES (1) ES2376252T3 (da)
GT (1) GT200600478A (da)
HN (1) HN2006037713A (da)
IL (1) IL190806A0 (da)
MA (1) MA29940B1 (da)
NL (1) NL2000299C2 (da)
NO (1) NO20082504L (da)
PE (1) PE20070642A1 (da)
PL (1) PL1948615T3 (da)
PT (1) PT1948615E (da)
RS (1) RS20080191A (da)
SI (1) SI1948615T1 (da)
TN (1) TNSN08202A1 (da)
TW (1) TWI321563B (da)
UA (1) UA90763C2 (da)
UY (1) UY29904A1 (da)
WO (1) WO2007054770A2 (da)
ZA (1) ZA200803670B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
SI1948615T1 (sl) * 2005-11-08 2012-02-29 Pfizer Ltd Derivati pirazola, uporabni za zdravljenje ginekoloških obolenj
WO2008014199A2 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 receptor
CA2664310A1 (en) 2006-09-25 2008-04-03 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2008135824A1 (en) * 2007-05-02 2008-11-13 Pfizer Limited Oxyalkylpyrazole compounds useful in therapy
WO2009061652A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
EP2283001A2 (en) * 2008-05-13 2011-02-16 Boehringer Ingelheim International GmbH Sulfone compounds which modulate the cb2 receptor
US8178568B2 (en) 2008-07-10 2012-05-15 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the CB2 receptor
CA2737639A1 (en) 2008-09-25 2010-04-01 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
EP2443107B1 (en) 2009-06-16 2018-08-08 Boehringer Ingelheim International GmbH Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
JP2013505295A (ja) 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US20110136815A1 (en) * 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
JP2013517271A (ja) 2010-01-15 2013-05-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
US20110263606A1 (en) * 2010-04-26 2011-10-27 Horst Zerbe Solid oral dosage forms comprising tadalafil
JP5746764B2 (ja) 2010-07-22 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
KR20210076069A (ko) * 2018-10-18 2021-06-23 난징 산홈 팔마세우티칼 컴퍼니 리미티드 TGF-βR1 억제제로서의 화합물 및 이의 적용
RU2711615C1 (ru) * 2019-09-12 2020-01-17 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" Способ лечения эндометриоза на основании экспериментальной модели у крыс
CN111269097B (zh) * 2020-04-02 2023-02-17 苏州爱玛特生物科技有限公司 一种多元环双取代的1,3-丙二酮类化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6281638A (ja) * 1985-10-07 1987-04-15 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
JPS63313784A (ja) * 1987-03-12 1988-12-21 Zeria Shinyaku Kogyo Kk 新規ピラゾール誘導体およびその製造法ならびにこれを有効成分とする抗潰瘍剤
DE4414792A1 (de) * 1993-08-11 1995-02-16 Bayer Ag Arzneimittel enthaltend 1-Thiocarbamoyl-5-hydroxypyrazolen und deren Verwendung als Mittel zur Bekämpfung des septischen Schocks
EE05400B1 (et) * 2001-04-10 2011-04-15 Pfizer Inc. Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks
GB0229618D0 (en) * 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
SI1948615T1 (sl) * 2005-11-08 2012-02-29 Pfizer Ltd Derivati pirazola, uporabni za zdravljenje ginekoloških obolenj

Also Published As

Publication number Publication date
NO20082504L (no) 2008-06-05
US7425569B2 (en) 2008-09-16
JP4234786B1 (ja) 2009-03-04
US20080085919A1 (en) 2008-04-10
ECSP088431A (es) 2008-06-30
DOP2006000245A (es) 2007-06-30
CY1112286T1 (el) 2015-12-09
PE20070642A1 (es) 2007-08-24
WO2007054770A3 (en) 2007-10-04
TW200804295A (en) 2008-01-16
IL190806A0 (en) 2008-11-03
MA29940B1 (fr) 2008-11-03
AU2006313478A1 (en) 2007-05-18
ES2376252T3 (es) 2012-03-12
EP1948615B1 (en) 2011-12-14
PL1948615T3 (pl) 2012-04-30
CA2628844C (en) 2011-12-06
CN101304974A (zh) 2008-11-12
TNSN08202A1 (fr) 2009-10-30
US7309712B2 (en) 2007-12-18
KR100997595B1 (ko) 2010-11-30
CR9959A (es) 2008-08-01
ZA200803670B (en) 2009-03-25
SI1948615T1 (sl) 2012-02-29
EA200801053A1 (ru) 2008-10-30
NL2000299C2 (nl) 2007-11-20
CA2628844A1 (en) 2007-05-18
EP1948615A2 (en) 2008-07-30
EA014693B1 (ru) 2010-12-30
TWI321563B (en) 2010-03-11
RS20080191A (en) 2009-07-15
KR20080056761A (ko) 2008-06-23
GT200600478A (es) 2007-06-08
UY29904A1 (es) 2007-06-29
AR056780A1 (es) 2007-10-24
HN2006037713A (es) 2010-06-09
BRPI0618630A2 (pt) 2011-09-06
JP2009514938A (ja) 2009-04-09
US20070105909A1 (en) 2007-05-10
NL2000299A1 (nl) 2007-05-09
ATE537150T1 (de) 2011-12-15
DK1948615T3 (da) 2012-02-06
UA90763C2 (ru) 2010-05-25
WO2007054770A2 (en) 2007-05-18
PT1948615E (pt) 2012-02-03

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