AP17A - Vaccine. - Google Patents
Vaccine. Download PDFInfo
- Publication number
- AP17A AP17A APAP/P/1986/000020A AP8600020A AP17A AP 17 A AP17 A AP 17A AP 8600020 A AP8600020 A AP 8600020A AP 17 A AP17 A AP 17A
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000009650 gentamicin protection assay Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000004201 immune sera Anatomy 0.000 description 1
- 229940042743 immune sera Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 244000000056 intracellular parasite Species 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000005497 microtitration Methods 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000008191 permeabilizing agent Substances 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 238000002135 phase contrast microscopy Methods 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000164 protein isolation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69911585A | 1985-02-07 | 1985-02-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP8600020A0 AP8600020A0 (en) | 1986-02-01 |
| AP17A true AP17A (en) | 1988-04-02 |
Family
ID=24808000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1986/000020A AP17A (en) | 1985-02-07 | 1986-02-07 | Vaccine. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0191748B1 (de) |
| JP (2) | JPH0698005B2 (de) |
| CN (1) | CN86100979A (de) |
| AP (1) | AP17A (de) |
| AT (1) | ATE82322T1 (de) |
| AU (1) | AU603054B2 (de) |
| DE (1) | DE3687071T2 (de) |
| DK (1) | DK62486A (de) |
| EG (1) | EG17878A (de) |
| ES (1) | ES8704975A1 (de) |
| GR (1) | GR860351B (de) |
| HU (1) | HU201803B (de) |
| IL (1) | IL77788A0 (de) |
| MY (1) | MY102249A (de) |
| NZ (1) | NZ215034A (de) |
| OA (1) | OA08199A (de) |
| PT (1) | PT81967B (de) |
| YU (1) | YU18186A (de) |
| ZA (1) | ZA86797B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE78869T1 (de) * | 1985-02-07 | 1992-08-15 | Smithkline Beecham Corp | Malaria-impfstoff. |
| IT1187710B (it) * | 1985-07-25 | 1987-12-23 | Eniricerche Spa | Composizione peptidica utile per la preparazione di vaccini per la malaria e di kit diagnostici per la determinazione di affezioni malariche |
| EP0252588A3 (de) * | 1986-05-12 | 1989-07-12 | Smithkline Beecham Corporation | Verfahren zur Isolierung und Reinigung von P. falciparum CS-Protein in rekombinantem E. coli sowie seine Verwendung als Impfstoff |
| EP0254862A1 (de) * | 1986-06-26 | 1988-02-03 | BEHRINGWERKE Aktiengesellschaft | Impfstoffe gegen protozoischen Parasiten |
| DE3752363T2 (de) * | 1986-11-04 | 2004-02-19 | Protein Polymer Technologies, Inc., San Diego | Herstellung synthetischer dns und deren verwendung bei der synthese grosser polypeptide |
| IT1198225B (it) * | 1986-12-04 | 1988-12-21 | Eniricerche Spa | Polipeptidi immunologicamente attivi utili per la preparazione di vaccini antimalaria e di kits diagnostici per la determinazione di anticorpi antisporozoita |
| AP56A (en) * | 1987-01-30 | 1989-09-26 | Smithkline Biologicals S A | Hepatitis B virus surface antigens and hybrid antigehs containing them. |
| JPH0222300A (ja) * | 1987-02-02 | 1990-01-25 | Swiss Serum & Vaccine Inst Bern | 免疫原性接合体およびその製法ならびに免疫を生ぜしめる方法 |
| AT388934B (de) * | 1987-11-13 | 1989-09-25 | Wellcome Found | Rekombinationskonjugatprotein und neue vakzinen |
| ATE95188T1 (de) * | 1987-12-23 | 1993-10-15 | Immuno Ag | Zellulaere amphipatische proteine in aggregierten formen und verfahren zur herstellung und reinigung diese proteine. |
| NZ233494A (en) * | 1989-05-03 | 1993-08-26 | Smithkline Beecham Corp | Polypeptides comprising plasmodium surface protein with a reduced number of repeating immunogenic determinants fused to a carrier protein; vectors coding therefor and vaccines |
| CA2031468A1 (en) * | 1989-12-08 | 1991-06-09 | Mitchell S. Gross | Malaria vaccine |
| MY175250A (en) | 2009-05-05 | 2020-06-17 | Cadila Healthcare Ltd | Combined measles-malaria vaccine |
| US20180153945A1 (en) * | 2016-12-05 | 2018-06-07 | The United States Of America, As Represented By The Secretary Of Agriculture | Oral e. coli vector-based vaccine for prevention of coccidiosis in poultry |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2145092B (en) * | 1983-01-28 | 1988-04-07 | Univ New York | Protective peptide antigen |
| US4466917A (en) * | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
| AU569722B2 (en) * | 1983-01-28 | 1988-02-18 | Saramane Pty Ltd | Expression of plasmodium falciparum polypeptides from cloned cdna |
| DE3584300D1 (de) * | 1984-02-21 | 1991-11-14 | Nat Res Dev | Herstellung von malaria-impfstoffen. |
| US4707357A (en) * | 1984-06-26 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor |
-
1985
- 1985-02-07 CN CN198686100979A patent/CN86100979A/zh active Pending
-
1986
- 1986-02-03 AT AT86870013T patent/ATE82322T1/de not_active IP Right Cessation
- 1986-02-03 EP EP86870013A patent/EP0191748B1/de not_active Expired - Lifetime
- 1986-02-03 DE DE8686870013T patent/DE3687071T2/de not_active Expired - Fee Related
- 1986-02-03 AU AU52936/86A patent/AU603054B2/en not_active Ceased
- 1986-02-04 ZA ZA86797A patent/ZA86797B/xx unknown
- 1986-02-04 PT PT81967A patent/PT81967B/pt not_active IP Right Cessation
- 1986-02-04 NZ NZ215034A patent/NZ215034A/xx unknown
- 1986-02-04 IL IL77788A patent/IL77788A0/xx unknown
- 1986-02-05 GR GR860351A patent/GR860351B/el unknown
- 1986-02-05 ES ES551656A patent/ES8704975A1/es not_active Expired
- 1986-02-06 HU HU86505A patent/HU201803B/hu not_active IP Right Cessation
- 1986-02-06 OA OA58779A patent/OA08199A/xx unknown
- 1986-02-06 EG EG64/86A patent/EG17878A/xx active
- 1986-02-06 JP JP61025660A patent/JPH0698005B2/ja not_active Expired - Lifetime
- 1986-02-07 AP APAP/P/1986/000020A patent/AP17A/en active
- 1986-02-07 DK DK62486A patent/DK62486A/da not_active Application Discontinuation
- 1986-02-07 YU YU00181/86A patent/YU18186A/xx unknown
-
1987
- 1987-10-12 MY MYPI87002891A patent/MY102249A/en unknown
-
1994
- 1994-05-20 JP JP6106595A patent/JPH07102150B2/ja not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| none * |
Also Published As
| Publication number | Publication date |
|---|---|
| DK62486A (da) | 1986-08-08 |
| AP8600020A0 (en) | 1986-02-01 |
| DK62486D0 (da) | 1986-02-07 |
| NZ215034A (en) | 1989-07-27 |
| OA08199A (en) | 1987-10-30 |
| HUT40917A (en) | 1987-03-30 |
| AU5293686A (en) | 1986-08-14 |
| PT81967B (pt) | 1988-07-01 |
| ATE82322T1 (de) | 1992-11-15 |
| EG17878A (en) | 1991-06-30 |
| DE3687071T2 (de) | 1993-03-25 |
| DE3687071D1 (de) | 1992-12-17 |
| JPH07102150B2 (ja) | 1995-11-08 |
| ZA86797B (en) | 1986-09-24 |
| YU18186A (en) | 1988-06-30 |
| CN86100979A (zh) | 1986-12-17 |
| MY102249A (en) | 1992-05-15 |
| IL77788A0 (en) | 1986-07-31 |
| ES8704975A1 (es) | 1987-04-16 |
| ES551656A0 (es) | 1987-04-16 |
| HU201803B (en) | 1990-12-28 |
| JPH07170995A (ja) | 1995-07-11 |
| PT81967A (en) | 1986-03-01 |
| JPH0698005B2 (ja) | 1994-12-07 |
| AU603054B2 (en) | 1990-11-08 |
| EP0191748B1 (de) | 1992-11-11 |
| EP0191748A1 (de) | 1986-08-20 |
| JPS61181387A (ja) | 1986-08-14 |
| GR860351B (en) | 1986-06-05 |
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