SG11201807903TA - A bioreactor system and method thereof - Google Patents

A bioreactor system and method thereof

Info

Publication number
SG11201807903TA
SG11201807903TA SG11201807903TA SG11201807903TA SG11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA
Authority
SG
Singapore
Prior art keywords
international
discs
rule
central shaft
pct
Prior art date
Application number
SG11201807903TA
Inventor
Ravindrakumar Dhirubhai Patel
Original Assignee
Ravindrakumar Dhirubhai Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ravindrakumar Dhirubhai Patel filed Critical Ravindrakumar Dhirubhai Patel
Publication of SG11201807903TA publication Critical patent/SG11201807903TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111011110110110111011111101111011111 International Bureau 0.. .... .. ..... ..or::,,,, (10) International Publication Number (43) International Publication Date WO 2017/158611 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C12M 1/00 (2006.01) C12M 1/12 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, C12M 3/00 (2006.01) C12M 1/02 (2006.01) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/IN2016/050336 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (22) International Filing Date: TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 4 October 2016 (04.10.2016) ZW. (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 201621008865 14 March 2016 (14.03.2016) IN TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventor; and LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant : PATEL, Ravindrakumar Dhirubhai SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, [IN/IN]; B-202, Royal Residency, Nr. Vandematram City, GW, KM, ML, MR, NE, SN, TD, TG). Nr. Gota Railway Crossing, Gota, Ahmedabad, Gujarat 382421 (IN). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) (74) Agents: ACHARYA, Rajeshkumar H. et al.; H K ACHARYA & COMPANY, Advocates•Patent & Trade- — as to applicant's entitlement to apply for and be granted a — marks Attorneys, HK Avenue, 19, Swastik Society Nav- patent (Rule 4.17(U)) — rangpura, Ahmedabad, Gujarat 380009 (IN). — of inventorship (Rule 4.17(iv)) Designated States indicated, (81) (unless otherwise for every Published: kind AE, AG, AL, AM, of national protection available): AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, — with international search report (Art. 21(3)) = BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, = = = (54) Title: A BIOREACTOR SYSTEM AND METHOD THEREOF = N. 2 = = ... ..... .......... = = 4\: '4k.,,,,, 1(b) i I/ 1 . :a ---- 19 = 5 3-, st, \ Il ,0.--,........ ‘‘k, Il 1-1 Fig.1 (a) GC iln (57) : The present invention relates to bioreactor system and method thereof wherein support matrix (2) comprises at last 1-1 --... one central shaft and plurality of peripheral shaft being radially surrounds central shaft. Arrays of discs (11) are mounted along the IN 1-1 shaft by defining interspatial vicinities between two successive plates. Thus, discs mounted on peripheral shafts are rotated within C the interspatial vicinity of discs of central shaft to ensures sufficient mixing and avoid stagnant fluidic zones which is created when N discs are mounted closely apart from each other on shafts. Further, plurality of deflector vanes that are axially provided along the Olength of the central shaft to redirect substantially co-axial direction fluid flow into interior of culture vessel and more specifically ,1. towards the central axis. Thus, bioreactor system provides scalable and disposable bioreactor with efficient mixing and homogen- eous conditions and thereby supports high density growth and maintenance of cells and other biological material.
SG11201807903TA 2016-03-14 2016-10-04 A bioreactor system and method thereof SG11201807903TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621008865 2016-03-14
PCT/IN2016/050336 WO2017158611A1 (en) 2016-03-14 2016-10-04 A bioreactor system and method thereof

Publications (1)

Publication Number Publication Date
SG11201807903TA true SG11201807903TA (en) 2018-10-30

Family

ID=57227026

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201807903TA SG11201807903TA (en) 2016-03-14 2016-10-04 A bioreactor system and method thereof

Country Status (18)

Country Link
US (1) US11365382B2 (en)
EP (1) EP3430119B1 (en)
JP (1) JP6840219B2 (en)
KR (1) KR102641877B1 (en)
CN (1) CN109196086B (en)
AU (1) AU2016397306B2 (en)
BR (1) BR112018068711B1 (en)
CA (1) CA3017434C (en)
DK (1) DK3430119T3 (en)
ES (1) ES2955959T3 (en)
FI (1) FI3430119T3 (en)
GB (1) GB2563794B (en)
IL (1) IL261716B (en)
MY (1) MY197074A (en)
PL (1) PL3430119T3 (en)
PT (1) PT3430119T (en)
SG (1) SG11201807903TA (en)
WO (1) WO2017158611A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11365382B2 (en) 2016-03-14 2022-06-21 Omnibrx Biotechnologies Private Limited Bioreactor system and method thereof

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3613841B1 (en) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passive replacement of media
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN109415696A (en) 2016-05-25 2019-03-01 泰尔茂比司特公司 Cell amplification
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
BE1024733B1 (en) 2016-11-09 2018-06-14 Univercells Sa CELL GROWTH MATRIX
CN117247899A (en) 2017-03-31 2023-12-19 泰尔茂比司特公司 cell expansion
WO2018200123A1 (en) * 2017-04-28 2018-11-01 Becton, Dickinson And Company Particle detection cartridges, systems thereof and methods for using the same
US20200308524A1 (en) * 2017-10-10 2020-10-01 Temple University-of The Commonwealth SAystem of Higher Education Device and Method for Enhanced Air Bubble Removal from Rotary Bioreactor Cell Cultures and Culture Chambers
JP7433232B2 (en) 2017-12-20 2024-02-19 ユニバーセルズ テクノロジーズ エス．エー． Bioreactors and related methods
EP3502229B1 (en) * 2017-12-22 2022-05-11 Evologic Technologies GmbH Inoculation vessel and bioreactor for hairy root cultures
CN108854881A (en) * 2018-06-20 2018-11-23 北京濮源新材料技术研究院(普通合伙) For producing the Novel disc reactor of polycarbonate
FI128391B (en) * 2019-01-14 2020-04-15 Solar Foods Oy Bioreactors for growing micro-organisms
US20200248123A1 (en) 2019-02-05 2020-08-06 Corning Incorporated Packed-bed bioreactor systems and methods of using the same
CN110416567B (en) * 2019-07-10 2022-05-31 上海交通大学 Membrane bioreactor for co-production of ethanol and electric energy by high-density microorganisms
WO2021043712A1 (en) * 2019-09-06 2021-03-11 Bayer Aktiengesellschaft System for planning, maintaining, managing and optimizing a production process
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same
WO2021207293A1 (en) * 2020-04-06 2021-10-14 Mission Barns, Inc. Scalable bioreactor systems and related methods of use
CN111500463A (en) * 2020-04-13 2020-08-07 青岛旭能生物工程有限责任公司 Method for continuously culturing chrysophyceae
CN111528103B (en) * 2020-07-01 2021-10-08 广州齐志生物工程设备有限公司 Plant tissue culture reactor and amplification culture method thereof
CN112947224A (en) * 2021-03-04 2021-06-11 镇江江工生物工程成套设备有限公司 Based on crooked formula bioreactor intelligence control system
WO2022241099A2 (en) * 2021-05-12 2022-11-17 Arizona Board Of Regents On Behalf Of The University Of Arizona In situ soil gas probes and sampling sytems
GB2608426A (en) * 2021-07-01 2023-01-04 Smdr Ltd Multi-disc catalytic reactor
WO2023023854A1 (en) * 2021-08-23 2023-03-02 Summit View Development Corp. A system and method for enhancing gas mass transfer
CN114149919B (en) * 2021-12-02 2023-06-23 鲁东大学 Culture device for cassava genetic information transformation
CN114276927B (en) * 2021-12-29 2024-05-10 上海日泰医药设备工程有限公司 Folding carrier column for bioreactor
CN114250147B (en) * 2021-12-29 2024-05-14 上海日泰医药设备工程有限公司 Biological reaction device
CN114317270B (en) * 2022-03-12 2022-06-17 广州赛太特生物医学科技有限公司 Cell culture device for biological gene research
CN114651725B (en) * 2022-04-21 2023-01-10 四川省农业科学院园艺研究所 Orchid seedling group banks up device with earth based on intelligent regulation and control
US11981884B2 (en) * 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same
CN117126736A (en) * 2023-10-26 2023-11-28 山东百沃生物科技有限公司 Biological culture device for enzyme conversion

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407120A (en) 1965-12-23 1968-10-22 Abbott Lab Tissue culture propagator and method
US3933585A (en) 1972-06-14 1976-01-20 Merck & Co., Inc. Process for production of vaccines
NL7307143A (en) 1972-06-14 1973-12-18
US4065359A (en) * 1975-05-01 1977-12-27 Merck & Co., Inc. Cell removing device
AU6156780A (en) 1979-08-24 1981-04-09 G.D. Searle & Co. Stack plate culture
GB2058131A (en) * 1979-08-24 1981-04-08 Searle & Co Stack plate culture
EP0289666B1 (en) 1987-04-03 1992-06-17 Yeda Research And Development Company Limited Cell culture carriers etc.
CH677496A5 (en) * 1988-04-05 1991-05-31 Gerd Kloss
JP3036032B2 (en) * 1990-09-17 2000-04-24 日立プラント建設株式会社 Cell culturing method and device
JPH04335882A (en) 1991-05-02 1992-11-24 Nitto Denko Corp Apparatus for culture
JPH04126068U (en) 1991-05-09 1992-11-17 株式会社エンヤシステム diaphragm valve
JP3453167B2 (en) 1993-06-22 2003-10-06 宇宙開発事業団 Continuous culture unit
JPH0775550A (en) 1993-09-10 1995-03-20 Ebara Corp Cell culture apparatus
JP3215862B2 (en) * 1995-03-02 2001-10-09 農林水産省農業研究センター所長 Bioreactor and method of using the same
US6589780B2 (en) * 2000-12-15 2003-07-08 Council Of Scientific And Industrial Research Bio-reactor for enhancing the biomass yield of plant organs
US7176024B2 (en) * 2003-05-30 2007-02-13 Biolex, Inc. Bioreactor for growing biological materials supported on a liquid surface
WO2008101127A2 (en) * 2007-02-15 2008-08-21 Broadley-James Corporation Bioreactor jacket
CN101486966B (en) * 2008-09-12 2012-12-26 广州齐志生物工程设备有限公司 Bioreactor and method for animal cell adherent culture
US20110281343A1 (en) * 2008-10-02 2011-11-17 Gay Roger J Bioreactor with rods arrayed for culturing anchorage-dependent cells
US8809037B2 (en) * 2008-10-24 2014-08-19 Bioprocessh20 Llc Systems, apparatuses and methods for treating wastewater
FR2943560B1 (en) * 2009-03-24 2011-05-27 Jean Pascal Zambaux DISPOSABLE BIOREACTOR AND AGITATOR SYSTEM FOR SINGLE USE
CN201459147U (en) * 2009-06-02 2010-05-12 北京必威安泰生物科技有限公司 Multi-shaft, multi-propeller bioreactor
AU2010275687A1 (en) * 2009-07-24 2012-01-12 F. Hoffmann-La Roche Ag Stirrer system
DE102010005415B4 (en) * 2010-01-22 2015-07-16 Zellwerk Gmbh Method and device for the dynamic expansion and / or differentiation of suspended primary cells or stem cells of human and animal origin
CN101805695B (en) * 2010-01-29 2012-06-13 福尔生物制药股份有限公司 Oblique rotational gravity mixed biological reaction equipment
WO2011097566A1 (en) 2010-02-08 2011-08-11 Renewable Process Technologies Llc System and method for producing biomaterials
US20130337548A1 (en) * 2010-03-04 2013-12-19 Utah State University Rotating Bioreactor
KR20130109000A (en) * 2010-05-11 2013-10-07 아르텔리스 에스에이 Apparatus and methods for cell culture
US20130196375A1 (en) * 2010-06-23 2013-08-01 Strobbe Tech A/S Biopharmaceutical process apparatuses assembled into a column
US20120196336A1 (en) * 2011-01-28 2012-08-02 Mccutchen Co. Radial counterflow reactor with applied radiant energy
DE102012002047A1 (en) * 2011-03-12 2012-09-13 Oerlikon Textile Gmbh & Co. Kg Dynamic mixer for blending polymer melt during melt spinning process for manufacturing synthetic threads, has sensor device arranged in region of outlet to measure physical parameters of melt and connected with control device
EP3572497A1 (en) 2011-06-06 2019-11-27 Regenesys bvba Expansion of stem cells in hollow fiber bioreactors
WO2013006681A2 (en) * 2011-07-06 2013-01-10 Joule Unlimited Technologies, Inc. Bioreactors circulation apparatus, system and method
JP5818619B2 (en) * 2011-10-05 2015-11-18 地方独立行政法人東京都立産業技術研究センター Slurry catalyst solution adhesion device
CN203360028U (en) * 2013-07-05 2013-12-25 攀钢集团钛业有限责任公司 Stirring shaft of continuous acidolysis reactor
WO2016013069A1 (en) 2014-07-23 2016-01-28 株式会社日立製作所 Cell culture device, cell culture system, and cell culture method
EP2988130A1 (en) 2014-08-20 2016-02-24 Eppendorf Ag Method for coating a solid support
CN104475000B (en) * 2014-12-04 2016-08-17 佛山市特赛化工设备有限公司 A kind of dynamic continuous production device of sizing finished product and production technology
DK3430119T3 (en) 2016-03-14 2023-09-18 Omnibrx Biotechnologies Private Ltd A BIOREACTOR SYSTEM AND ITS OPERATION

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11365382B2 (en) 2016-03-14 2022-06-21 Omnibrx Biotechnologies Private Limited Bioreactor system and method thereof

Also Published As

Publication number Publication date
EP3430119B1 (en) 2023-06-07
CN109196086A (en) 2019-01-11
IL261716B (en) 2022-03-01
KR102641877B1 (en) 2024-02-27
CA3017434A1 (en) 2017-09-21
EP3430119A1 (en) 2019-01-23
PT3430119T (en) 2023-09-12
ES2955959T3 (en) 2023-12-11
BR112018068711B1 (en) 2022-06-21
FI3430119T3 (en) 2023-09-11
PL3430119T3 (en) 2023-11-13
BR112018068711A2 (en) 2019-01-22
MY197074A (en) 2023-05-24
GB201816573D0 (en) 2018-11-28
GB2563794B (en) 2021-02-24
CN109196086B (en) 2022-04-26
JP2019512270A (en) 2019-05-16
US11365382B2 (en) 2022-06-21
CA3017434C (en) 2024-01-09
WO2017158611A1 (en) 2017-09-21
IL261716A (en) 2018-10-31
KR20190128546A (en) 2019-11-18
JP6840219B2 (en) 2021-03-10
AU2016397306B2 (en) 2022-02-03
GB2563794A (en) 2018-12-26
AU2016397306A1 (en) 2018-11-01
DK3430119T3 (en) 2023-09-18
US20180187139A1 (en) 2018-07-05

Similar Documents

Publication Publication Date Title
SG11201807903TA (en) A bioreactor system and method thereof
Todhunter et al. Programmed synthesis of three-dimensional tissues
SG11201808681UA (en) Hydroponic cultivation unit and system
SG11201407802WA (en) Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
SG11201804372PA (en) Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9
SG11201810286WA (en) Variable diameter bioreactors
SG11201811048UA (en) Single-cell transcript sequencing
SG11201407226WA (en) Improved methods of cell culture for adoptive cell therapy
SG11201811435PA (en) Automated cell processing systems and methods
SG11201908337VA (en) Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
SG11201406903SA (en) Cell culture compositions and methods for polypeptide production
SG11201407702XA (en) Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
SG11201908127WA (en) Method for producing multispecific antibodies
SG11201909331UA (en) Antigen-specific immune effector cells
SG11201805119QA (en) Methods to determine tumor gene copy number by analysis of cell-free dna
SG11201407486PA (en) Compositions and methods for modulating utrn expression
SG11201900772YA (en) Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
SG11201804205UA (en) Media mixing chamber
SG11201809515VA (en) Charged isoporous materials for electrostatic separations
SG11201908240YA (en) Methods for evaluating tumor cell spheroids using 3d microfluidic cell culture device
SG11201404936YA (en) Channel plate heat transfer system
SG11201407710VA (en) Compositions comprising short-acting benzodiazepines
SG11201903353WA (en) Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof
SG11201407800SA (en) Selective binding of biological targets to solid phase ureides
SG11201809051YA (en) Cell retention device and method