CN201459147U - Multi-shaft, multi-propeller bioreactor - Google Patents
Multi-shaft, multi-propeller bioreactor Download PDFInfo
- Publication number
- CN201459147U CN201459147U CN 200920108811 CN200920108811U CN201459147U CN 201459147 U CN201459147 U CN 201459147U CN 200920108811 CN200920108811 CN 200920108811 CN 200920108811 U CN200920108811 U CN 200920108811U CN 201459147 U CN201459147 U CN 201459147U
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- China
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- stirring
- shell
- shaft
- stirring rake
- stir shaft
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model relates to a multi-shaft, multi-propeller bioreactor, which comprises a tank-shaped shell, stirring propellers and two or more stirring shafts, and the upper ends of the stirring shafts are rotatably inserted into the shell and connected with the stirring propellers. The bioreactor has the following characteristics that: the stirring shafts are evenly arranged on the axis of the shell and/or a circle with the axis of the shell as the centre of the circle, and each stirring shaft is provided with a stirring propeller. The utility model has the following advantages that: under the premise that the same reactor size can achieve the same stirring effect, multi-shaft stirring can allow the diameter and rotation speed of the stirring propeller to be reduced compared with single-shaft stirring, and thereby the shearing force generated by the blades can be reduced. Consequently, the multi-shaft stirring bioreactor can carry out cell culture on a larger scale.
Description
Technical field
The utility model relates to a kind of many oars of multiaxis stirring type bioreactor, is used for the large scale culturing to the suspension cell of shearing force sensitivity.
Background technology
The structure of existing stirring type bioreactor comprises a jar shape shell, a stir shaft and some stirring rakes, and the upper end of stir shaft is rotated to penetrate in the shell and with stirring rake and is connected, and stir shaft is positioned at the axle center of shell.In cell cultivation process, need to keep the well blend of liquid, be beneficial to the exchange of substance and the gravity settling of avoiding cell of cell growth; Promote the dissolving and the emission of carbon-dioxide of oxygen simultaneously.Achieve the above object, stirring system need be kept certain stirring dynamics, but along with the increase of reactor volume, the linear velocity of stirring rake is also increasing, and the shearing force that produces during greater than certain value when the linear speed of stirring rake will cause damage by pair cell.Single shaft stirs the volume of culture that has limited bio-reactor, and this is the bottleneck of mass cell suspension culture.
Summary of the invention
The purpose of this utility model just provides a kind of many oars of multiaxis bio-reactor, with solve that prior art exists can not scale operation problem.
The technical solution adopted in the utility model is: comprise a jar shape shell, stirring rake and stir shaft, the upper end of stir shaft is rotated to penetrate in the shell and with stirring rake and is connected, it is characterized in that: described stir shaft is provided with two or more than two, this stir shaft is evenly distributed on the axle center of described shell and/or is on the circumference in the center of circle with the axle center of shell, on each root stir shaft described stirring rake is housed all.
The shape of cross section of described shell is shape circular or that match with the circumscribed circle of described stirring rake.
Stirring rake on each described stir shaft is one or more than one, the size of stirring rake, array mode and number are not limit.
The utility model has the advantages that: at identical reactor volume, reach under the prerequisite of identical mixing effect, multiaxis stirs to stir with single shaft and compares, and can reduce stirring rake diameter and rotating speed, reduces the shearing force that blade produced.Therefore, the multiaxis stirred reactor can be finished more massive cell cultures.
Description of drawings
Fig. 1 is the axial sectional structure synoptic diagram of an embodiment of the present utility model;
Fig. 2 is one of A-A sectional view of Fig. 1 (shell of rounded section);
Fig. 3 is two (shells of multi sphere tee section) of the A-A sectional view of Fig. 1;
Fig. 4 is the axial sectional structure synoptic diagram of another embodiment of the present utility model;
Fig. 5 is one of B-B sectional view of Fig. 4 (shell of rounded section);
Fig. 6 is two (shells of multi sphere tee section) of the B-B sectional view of Fig. 4.
Embodiment
Referring to Fig. 1～Fig. 6, the utility model comprises a jar shape shell 1, stirring rake 2 and stir shaft 3, and the upper end of stir shaft 3 is rotated in the top that penetrates shell 1 and with stirring rake 2 and is connected.Described stir shaft 3 is provided with two or more than two (as three of Fig. 1～shown in Figure 3), the axle center that this stir shaft 3 is evenly distributed on shell is on the circumference in the center of circle, and two (also can more than two) described stirring rakes 2 (as Fig. 1～shown in Figure 3) all are housed on each this stir shaft 3.Also a stir shaft 3 can also be set in the axle center of shell 1, can only install a stirring rake 2 this moment on each stir shaft 3, stirring rake 2 on the stir shaft 3 in axle center staggers mutually with stirring rake 2 on three stir shafts 3 on every side (as Fig. 4～shown in Figure 6), so that mixing effect is better.
According to the size of shell, can be on each described stir shaft 3 be installed as one or at interval more than a stirring rake 2.The size of stirring rake 2, number and array mode can be according to the shape and the size decisions of shell 1.
The shape of cross section of described shell 1 is circular (as Fig. 2 and shown in Figure 5); Or the shape (as Fig. 3 and shown in Figure 6) that matches with the circumscribed circle of described stirring rake 2, several stirring rakes 2 circumscribed circles of the latter's non-circular shape and circle distribution coincide mutually, eliminate and stir the dead angle, help stirring evenly.
Claims (3)
1. many oars of multiaxis bio-reactor, comprise a jar shape shell, stirring rake and stir shaft, the upper end of stir shaft is rotated to penetrate in the shell and with stirring rake and is connected, it is characterized in that: described stir shaft is provided with two or more than two, this stir shaft is evenly distributed on the axle center of described shell and/or is on the circumference in the center of circle with the axle center of shell, on each this stir shaft described stirring rake is housed all.
2. many oars of multiaxis bio-reactor according to claim 1 is characterized in that: the shape of cross section of described shell is shape circular or that match with the circumscribed circle of described stirring rake.
3. many oars multiaxis bio-reactor according to claim 1 is characterized in that: the stirring rake on each described stir shaft is one or more than one, the size of stirring rake, array mode and number are not limit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200920108811 CN201459147U (en) | 2009-06-02 | 2009-06-02 | Multi-shaft, multi-propeller bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200920108811 CN201459147U (en) | 2009-06-02 | 2009-06-02 | Multi-shaft, multi-propeller bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201459147U true CN201459147U (en) | 2010-05-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200920108811 Expired - Fee Related CN201459147U (en) | 2009-06-02 | 2009-06-02 | Multi-shaft, multi-propeller bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201459147U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012100510A1 (en) * | 2011-01-24 | 2012-08-02 | 上海众伟生化有限公司 | Dual body circulatory reactor for cellulose enzymolysis and application thereof |
| CN102876571A (en) * | 2011-07-12 | 2013-01-16 | 上海众伟生化有限公司 | High-capacity double-systematic-circulation cellulose enzymolysis reactor and its application |
| CN109196086A (en) * | 2016-03-14 | 2019-01-11 | R·D·帕特尔 | bioreactor system and its method |
-
2009
- 2009-06-02 CN CN 200920108811 patent/CN201459147U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012100510A1 (en) * | 2011-01-24 | 2012-08-02 | 上海众伟生化有限公司 | Dual body circulatory reactor for cellulose enzymolysis and application thereof |
| CN102876571A (en) * | 2011-07-12 | 2013-01-16 | 上海众伟生化有限公司 | High-capacity double-systematic-circulation cellulose enzymolysis reactor and its application |
| CN102876571B (en) * | 2011-07-12 | 2014-11-05 | 上海众伟生化有限公司 | High-capacity double-systematic-circulation cellulose enzymolysis reactor and its application |
| CN109196086A (en) * | 2016-03-14 | 2019-01-11 | R·D·帕特尔 | bioreactor system and its method |
| CN109196086B (en) * | 2016-03-14 | 2022-04-26 | Omnibrx生物科技私人有限公司 | Bioreactor system and method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: INNER MONGOLIA BIGVET BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: BIGVET BIOTECH CO., LTD.;THE REGIONAL SPECIALTY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES Effective date: 20110331 Free format text: FORMER OWNER: GAO YUN |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100176 2/F, BAOJI'AN BUILDING, NO. 6, KANGDING STREET, YIZHUANG ECONOMIC DEVELOPMENT ZONE, BEIJING TO: 010176 200 METERS EAST OF POLICE STATION, SHENGLE ECONOMIC DEVELOPMENT ZONE, HELIN COUNTY, HOHHOT CITY, INNER MONGOLIA AUTONOMOUS REGION |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20110331 Address after: 010176 the Inner Mongolia Autonomous Region and Hohhot County police station Shengle Economic Development Zone East 200 meters Patentee after: INNER MONGOLIA BIWEI ANTAI BIOTECHNOLOGY CO., LTD. Address before: Two, building 6, Ji'an building, 100176 Kangding street, Yizhuang Economic Development Zone, Beijing, China Co-patentee before: Institute of Specialty, Chinese Academy of Agricultural Sciences Patentee before: Beijing Bigvet Biotechnology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100512 Termination date: 20180602 |