MX2020010275A - Uso de fibras huecas para obtener sangre o un derivado sanguineo empobrecido de celulas sanguineas y plaquetas derivadas de vesiculas extracelulares. - Google Patents

Uso de fibras huecas para obtener sangre o un derivado sanguineo empobrecido de celulas sanguineas y plaquetas derivadas de vesiculas extracelulares.

Info

Publication number
MX2020010275A
MX2020010275A MX2020010275A MX2020010275A MX2020010275A MX 2020010275 A MX2020010275 A MX 2020010275A MX 2020010275 A MX2020010275 A MX 2020010275A MX 2020010275 A MX2020010275 A MX 2020010275A MX 2020010275 A MX2020010275 A MX 2020010275A
Authority
MX
Mexico
Prior art keywords
blood
hollow fibers
impoverished
extracellular vesicles
derived extracellular
Prior art date
Application number
MX2020010275A
Other languages
English (en)
Inventor
Antonio Chiesi
Natasa Zarovni
Davide Zocco
Original Assignee
Exosomics S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exosomics S P A filed Critical Exosomics S P A
Publication of MX2020010275A publication Critical patent/MX2020010275A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02834—Pore size more than 0.1 and up to 1 µm
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Artificial Filaments (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con el uso de fibras huecas que tienen una porosidad por arriba de 20 nm, en particular fibras huecas de polietersulfona, para empobrecer sangre y derivados sanguíneos de vesículas extracelulares derivadas de sangre, en particular exosomas y exómeros, y a métodos para obtener y analizar esas muestras empobrecidas.
MX2020010275A 2018-03-30 2019-03-29 Uso de fibras huecas para obtener sangre o un derivado sanguineo empobrecido de celulas sanguineas y plaquetas derivadas de vesiculas extracelulares. MX2020010275A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18165289 2018-03-30
PCT/EP2019/058028 WO2019185874A1 (en) 2018-03-30 2019-03-29 Use of hollow fibers to obtain blood or a blood derivative impoverished from blood cells and platelets derived extracellular vesicles

Publications (1)

Publication Number Publication Date
MX2020010275A true MX2020010275A (es) 2020-11-06

Family

ID=61868373

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020010275A MX2020010275A (es) 2018-03-30 2019-03-29 Uso de fibras huecas para obtener sangre o un derivado sanguineo empobrecido de celulas sanguineas y plaquetas derivadas de vesiculas extracelulares.

Country Status (9)

Country Link
US (1) US20210025795A1 (es)
EP (1) EP3775882A1 (es)
JP (1) JP7337438B2 (es)
CN (1) CN112055814B (es)
AU (1) AU2019240901A1 (es)
BR (1) BR112020020083A2 (es)
CA (1) CA3094577A1 (es)
MX (1) MX2020010275A (es)
WO (1) WO2019185874A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230028621A1 (en) 2019-12-23 2023-01-26 Biopsense Oy Method, automated system and cartridge for extraction of cell-free nucleic acids from a blood sample
WO2023194465A1 (en) * 2022-04-06 2023-10-12 Grifols Worldwide Operations Limited Extracellular vesicle depleted blood fractions

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6802820B1 (en) 2000-04-13 2004-10-12 Transvivo, Inc. Specialized hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration
US20040241176A1 (en) 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
DE10256848A1 (de) * 2002-12-04 2004-07-08 Sibylle Latza Verfahren und Vorrichtung zum Separieren von Vollblut unter Schwerkraft in ein Erythrozytenkonzentrat und Plasma
JP4093134B2 (ja) 2003-08-22 2008-06-04 東洋紡績株式会社 中空糸型血液浄化膜
WO2005043121A2 (en) * 2003-10-31 2005-05-12 Vitatex, Inc. Blood test prototypes and methods for the detection of circulating tumor and endothelial cells
ES2736726T3 (es) 2006-03-09 2020-01-07 Aethlon Medical Inc Eliminación extracorpórea de partículas microvesiculares
WO2007127848A1 (en) 2006-04-26 2007-11-08 University Of Louisville Research Foundation, Inc Isolation of membrane vesicles from biological fluids and methods of using same
US8297959B2 (en) * 2006-05-03 2012-10-30 Terapia Celular, Ln, Inc. Systems for producing multilayered particles, fibers and sprays and methods for administering the same
EP2380905A1 (en) * 2010-04-19 2011-10-26 Thrombotargets Europe, S.L. Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof
WO2012054975A1 (en) * 2010-10-28 2012-05-03 Clinical Genomics Pty. Ltd. Method of microvesicle enrichment
JP2012143554A (ja) 2010-12-24 2012-08-02 Toray Ind Inc ポリスルホン系中空糸膜及び血小板浮遊液浄化用中空糸膜モジュール並びに血小板浮遊液の浄化方法
TWI549744B (zh) * 2012-03-28 2016-09-21 東麗股份有限公司 血液製劑淨化用的聚碸系中空絲膜以及中空絲膜模組
KR20140050465A (ko) * 2012-10-19 2014-04-29 포항공과대학교 산학협력단 다공성 중합체 모노리드 필터를 포함하는 체액으로부터 세포밖 소포를 분리하기 위한 장치
US10725024B2 (en) * 2013-03-28 2020-07-28 The University Of British Columbia Microfluidic devices and methods for use thereof in multicellular assays of secretion
DE102013010735A1 (de) * 2013-06-27 2015-01-15 Mann + Hummel Gmbh Keramisches Vollbluthohlfasermembranfiltermedium und Verwendung davon zum Abtrennen von Blutplasma/-serum von Vollblut
DK3110977T3 (en) 2014-02-28 2018-07-23 Exosome Sciences Inc BRAIN SPECIFIC EXOSOME-BASED DIAGNOSTIC AND EXTRACORPORAL THERAPIES
CA2950977C (en) 2014-06-06 2023-10-10 Exosomics Siena S.P.A. Use of tm9sf4 as a biomarker for tumor associated exosomes
WO2016157142A1 (en) * 2015-04-02 2016-10-06 Stegi-Ra Trust Composition for use in treating celiac disease
EP3093032B1 (de) * 2015-05-11 2018-09-19 3M Innovative Properties Company System und verfahren zur gewinnung von serum
US10160964B2 (en) * 2015-05-13 2018-12-25 Norgen Biotek Corp. Methods for extracellular vesicle isolation and selective removal
US11073511B2 (en) * 2016-02-01 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers
CN105651995B (zh) * 2016-02-19 2018-02-27 武汉大复生物科技有限公司 检测CD105、CD144、CD34、KDR、Annexin V和CD63的试剂在制备检测血液中的内皮及内皮祖细胞释放的细胞外囊泡的试剂中的应用
EP3246703A1 (en) * 2016-05-20 2017-11-22 Unicyte EV AG Method and kit for capturing extracellular vesicles (evs) on a solid surface
CN107655865B (zh) * 2016-07-25 2021-10-19 希森美康株式会社 血液分析装置及血液分析方法

Also Published As

Publication number Publication date
CN112055814A (zh) 2020-12-08
CA3094577A1 (en) 2019-10-03
US20210025795A1 (en) 2021-01-28
JP2021519421A (ja) 2021-08-10
RU2020135585A (ru) 2022-05-05
JP7337438B2 (ja) 2023-09-04
BR112020020083A2 (pt) 2021-01-05
EP3775882A1 (en) 2021-02-17
AU2019240901A2 (en) 2020-11-12
WO2019185874A1 (en) 2019-10-03
CN112055814B (zh) 2024-04-02
AU2019240901A1 (en) 2020-10-29

Similar Documents

Publication Publication Date Title
CR20180480A (es) Receptores quiméricos y métodos de uso de los mismos
CL2018002792A1 (es) Receptores quiméricos de flt3 y métodos de uso de los mismos.
CY1124977T1 (el) Αντισωματα anti-lag-3 για αγωγη αιματολογικων κακοηθειων
PH12014501472A1 (en) Fiber composition comprising 1,3-glucan and a method of preparing same
WO2018102795A3 (en) Synthetic immune receptors and methods of use thereof
MX2020010275A (es) Uso de fibras huecas para obtener sangre o un derivado sanguineo empobrecido de celulas sanguineas y plaquetas derivadas de vesiculas extracelulares.
EP4219449A3 (en) Substituted indole derivatives and methods of preparation thereof
CY1118105T1 (el) Αγγειογενεση χρησιμοποιωντας πλακουντιακα βλαστικα κυτταρα
SG10201808523RA (en) Il-22 polypeptides and il-22 fc fusion proteins and methods of use
EP1784639A4 (en) PROCESS FOR PREPARING FREEZERTED BLOOD PLATES, FLUIDIZED BLOOD PLATES, COMPOSITIONS AND USE METHOD
BRPI0607045A2 (pt) células estromais adultas derivadas de adiposas exibindo caracterìsticas de células endoteliais
EA201101519A1 (ru) Способы диагностики метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
BR112018000632A2 (pt) moléculas de anticorpo que ligam a cd79
WO2008063842A3 (en) Methods of treating neuropathic pain with agonists of ppar-gamma
MD3529262T2 (ro) Metode pentru promovarea răspunsului celulelor T
MX2017006242A (es) Determinacion de niveles de glicosaminoglicanos mediante espectrometria de masas.
WO2010007502A3 (en) Platelet fraction deriving from placental blood
WO2014174114A3 (en) Hair dyeing process using henna and then indigo and an oil and/or butter
WO2017120545A3 (en) Systems and methods for preparation of platelets
MX2022010954A (es) Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo.
MA34978B1 (fr) Antidotes pour anticoagulants
CL2023003182A1 (es) Receptores químericos de steap1 y métodos de uso de los mismos
TR201909997T4 (tr) 5-HT4 reseptör agonistleri olarak amid bileşikleri.
AR122422A1 (es) Métodos para enriquecer vesículas extracelulares de muestras de líquido biológico
YU90301A (sh) Konjugati i postupci za njihovu proizvodnju i njihova upotreba za transport molekula kroz biološke membrane