IL128690A - Cyclic amine derivatives and pharmaceutical compositions containing the same - Google Patents
Cyclic amine derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL128690A IL128690A IL12869097A IL12869097A IL128690A IL 128690 A IL128690 A IL 128690A IL 12869097 A IL12869097 A IL 12869097A IL 12869097 A IL12869097 A IL 12869097A IL 128690 A IL128690 A IL 128690A
- Authority
- IL
- Israel
- Prior art keywords
- alkoxy
- alkyl
- substituted
- optionally substituted
- halo
- Prior art date
Links
- -1 Cyclic amine Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22650796 | 1996-08-28 | ||
| PCT/JP1997/002990 WO1998008811A1 (fr) | 1996-08-28 | 1997-08-28 | Derives cycliques d'amines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL128690A0 IL128690A0 (en) | 2000-01-31 |
| IL128690A true IL128690A (en) | 2003-03-12 |
Family
ID=16846212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12869097A IL128690A (en) | 1996-08-28 | 1997-08-28 | Cyclic amine derivatives and pharmaceutical compositions containing the same |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6087379A (xx) |
| EP (1) | EP0934928B1 (xx) |
| KR (1) | KR100417887B1 (xx) |
| CN (1) | CN1192019C (xx) |
| AT (1) | ATE279389T1 (xx) |
| AU (1) | AU715531B2 (xx) |
| CA (1) | CA2263983C (xx) |
| CZ (1) | CZ300295B6 (xx) |
| DE (1) | DE69731218T2 (xx) |
| ES (1) | ES2229382T3 (xx) |
| HU (1) | HU228082B1 (xx) |
| IL (1) | IL128690A (xx) |
| NO (1) | NO312955B1 (xx) |
| NZ (1) | NZ334389A (xx) |
| PT (1) | PT934928E (xx) |
| RU (1) | RU2163596C2 (xx) |
| WO (1) | WO1998008811A1 (xx) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID25589A (id) * | 1998-02-27 | 2000-10-19 | Sankyo Company Ltd Cs | Senyawa-senyawa amino siklik |
| WO2001094304A1 (fr) * | 2000-06-08 | 2001-12-13 | Kaneka Corporation | Procede de production d'esters sulfoniques |
| WO2005051913A1 (ja) * | 2003-11-28 | 2005-06-09 | Sankyo Company, Limited | ヘテロアリール環を有する環状アミン誘導体 |
| BRPI0512535A (pt) | 2004-06-24 | 2008-03-25 | Incyte Corp | compostos de piperidinas n-substituìdas, suas composições e métodos de modulações |
| JP2008504279A (ja) * | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| US20090306059A1 (en) * | 2005-05-13 | 2009-12-10 | Tomio Kimura | Cyclic amine derivative having substituted alkyl group |
| WO2006126676A1 (ja) * | 2005-05-27 | 2006-11-30 | Daiichi Sankyo Company, Limited | 置換アルキル基を有する環状アミン誘導体 |
| EP1940399A2 (en) * | 2005-08-19 | 2008-07-09 | Eli Lilly & Company | Use of par-i/par- 4 inhibitors for treating or preventing vascular diseases |
| KR101044559B1 (ko) * | 2007-09-20 | 2011-06-28 | 국제약품공업주식회사 | 티올 화합물의 산부가염 및 그의 제조방법 |
| BRPI1016130A2 (pt) * | 2009-04-02 | 2017-03-28 | Shionogi & Co | composto, composição farmacêutica, e , métodos para tratar ou prevenir um distúrbio e uma condição. |
| DE202009018503U1 (de) | 2009-04-30 | 2011-11-16 | Saint-Gobain Sekurit Deutschland Gmbh & Co. Kg | Infrarotstrahlung abschirmendes, für sichtbares Licht transparentes Laminat mit einem für Infrarotstrahlung durchlässigen optischen Fenster |
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| CN106554303A (zh) * | 2015-09-25 | 2017-04-05 | 陕西合成药业股份有限公司 | 噻吩并吡啶类衍生物及其制备方法和用途 |
| CN105481760A (zh) * | 2016-01-20 | 2016-04-13 | 天津药物研究院有限公司 | 衍生化的替比格雷活性代谢产物的制备方法 |
| CN111484446A (zh) * | 2020-04-02 | 2020-08-04 | 北京翼方生物科技有限责任公司 | 氯吡格雷代谢活性体二硫衍生物、其制备方法及医药用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2215948B1 (xx) * | 1973-02-01 | 1976-05-14 | Centre Etd Ind Pharma | |
| FR2495156A1 (fr) * | 1980-11-28 | 1982-06-04 | Sanofi Sa | Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique |
| FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
| FR2576901B1 (fr) * | 1985-01-31 | 1987-03-20 | Sanofi Sa | Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique |
| FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
| FI101150B (fi) * | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
| JPH07503459A (ja) * | 1992-01-21 | 1995-04-13 | グラクソ、グループ、リミテッド | 酢酸誘導体 |
| EP0621037B1 (de) * | 1993-04-23 | 1999-07-07 | Hoechst Aktiengesellschaft | Pyrido-pyrimidindione, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU698748B2 (en) * | 1993-09-17 | 1998-11-05 | Brigham And Women's Hospital | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
-
1997
- 1997-07-28 NZ NZ334389A patent/NZ334389A/en not_active IP Right Cessation
- 1997-08-28 IL IL12869097A patent/IL128690A/xx not_active IP Right Cessation
- 1997-08-28 KR KR10-1999-7001526A patent/KR100417887B1/ko active IP Right Grant
- 1997-08-28 DE DE69731218T patent/DE69731218T2/de not_active Expired - Lifetime
- 1997-08-28 EP EP97937814A patent/EP0934928B1/en not_active Expired - Lifetime
- 1997-08-28 WO PCT/JP1997/002990 patent/WO1998008811A1/ja active IP Right Grant
- 1997-08-28 HU HU9903762A patent/HU228082B1/hu not_active IP Right Cessation
- 1997-08-28 CN CNB971992452A patent/CN1192019C/zh not_active Expired - Lifetime
- 1997-08-28 CZ CZ0063099A patent/CZ300295B6/cs not_active IP Right Cessation
- 1997-08-28 CA CA002263983A patent/CA2263983C/en not_active Expired - Lifetime
- 1997-08-28 AU AU40312/97A patent/AU715531B2/en not_active Expired
- 1997-08-28 AT AT97937814T patent/ATE279389T1/de active
- 1997-08-28 PT PT97937814T patent/PT934928E/pt unknown
- 1997-08-28 ES ES97937814T patent/ES2229382T3/es not_active Expired - Lifetime
- 1997-08-28 RU RU99104152/04A patent/RU2163596C2/ru active
-
1999
- 1999-02-25 US US09/257,818 patent/US6087379A/en not_active Expired - Lifetime
- 1999-02-26 NO NO19990951A patent/NO312955B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0934928B1 (en) | 2004-10-13 |
| NZ334389A (en) | 2001-05-25 |
| CZ300295B6 (cs) | 2009-04-15 |
| NO312955B1 (no) | 2002-07-22 |
| WO1998008811A1 (fr) | 1998-03-05 |
| ES2229382T3 (es) | 2005-04-16 |
| KR20000035839A (ko) | 2000-06-26 |
| PT934928E (pt) | 2004-12-31 |
| US6087379A (en) | 2000-07-11 |
| NO990951D0 (no) | 1999-02-26 |
| CN1235596A (zh) | 1999-11-17 |
| AU4031297A (en) | 1998-03-19 |
| EP0934928A4 (en) | 2001-05-09 |
| RU2163596C2 (ru) | 2001-02-27 |
| EP0934928A1 (en) | 1999-08-11 |
| CN1192019C (zh) | 2005-03-09 |
| AU715531B2 (en) | 2000-02-03 |
| IL128690A0 (en) | 2000-01-31 |
| CA2263983C (en) | 2006-03-21 |
| KR100417887B1 (ko) | 2004-02-11 |
| DE69731218D1 (de) | 2004-11-18 |
| DE69731218T2 (de) | 2005-06-30 |
| CZ63099A3 (cs) | 1999-07-14 |
| ATE279389T1 (de) | 2004-10-15 |
| CA2263983A1 (en) | 1998-03-05 |
| HU228082B1 (en) | 2012-10-29 |
| NO990951L (no) | 1999-04-27 |
| HUP9903762A2 (hu) | 2000-02-28 |
| HUP9903762A3 (en) | 2001-02-28 |
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