ZA984635B - Orally active iron (III) chelators. - Google Patents
Orally active iron (III) chelators.Info
- Publication number
- ZA984635B ZA984635B ZA9804635A ZA984635A ZA984635B ZA 984635 B ZA984635 B ZA 984635B ZA 9804635 A ZA9804635 A ZA 9804635A ZA 984635 A ZA984635 A ZA 984635A ZA 984635 B ZA984635 B ZA 984635B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydrogen
- aryl
- group
- aralkyl
- alkyl
- Prior art date
Links
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 title 1
- 239000002738 chelating agent Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- -1 3-hydroxypyridin-4-one compound Chemical class 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- KICQOVVEMVVNSD-UHFFFAOYSA-N 1-ethyl-3-hydroxy-2-(1-hydroxyethyl)pyridin-4-one Chemical compound CCN1C=CC(=O)C(O)=C1C(C)O KICQOVVEMVVNSD-UHFFFAOYSA-N 0.000 abstract 1
- ZCUUVWCJGRQCMZ-UHFFFAOYSA-N 3-hydroxypyridin-4-one Natural products OC1=CC=NC=C1O ZCUUVWCJGRQCMZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9711093.6A GB9711093D0 (en) | 1997-05-29 | 1997-05-29 | Novel orally active iron (III) chelators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA984635B true ZA984635B (en) | 1999-11-29 |
Family
ID=10813233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9804635A ZA984635B (en) | 1997-05-29 | 1998-05-29 | Orally active iron (III) chelators. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6335353B1 (xx) |
| EP (1) | EP0984934B1 (xx) |
| JP (1) | JP2002500663A (xx) |
| AT (1) | ATE230728T1 (xx) |
| AU (1) | AU751600B2 (xx) |
| CA (1) | CA2287907C (xx) |
| DE (1) | DE69810619T2 (xx) |
| DK (1) | DK0984934T3 (xx) |
| ES (1) | ES2187025T3 (xx) |
| GB (1) | GB9711093D0 (xx) |
| WO (1) | WO1998054138A1 (xx) |
| ZA (1) | ZA984635B (xx) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| KR20100075503A (ko) | 1999-10-01 | 2010-07-02 | 디엠아이 바이오사이언시스, 인크 | 금속 결합 화합물 및 그의 용도 |
| US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US6426418B1 (en) | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
| JP2005516987A (ja) | 2002-02-05 | 2005-06-09 | ブリストル−マイヤーズ スクイブ カンパニー | Ｎ−置換された３−ヒドロキシ−４−ピリジノン化合物およびそれを含む医薬 |
| AU2003282337B2 (en) | 2002-11-07 | 2009-07-16 | Technion Research And Development Foundation Ltd. | Neuroprotective iron chelators and pharmaceutical compositions comprising them |
| NZ529657A (en) * | 2003-11-20 | 2004-07-30 | Apotex Inc | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
| CA2488034C (en) * | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
| GB0506677D0 (en) * | 2005-04-01 | 2005-05-11 | Btg Int Ltd | Iron modulators |
| CA2681545C (en) | 2007-03-28 | 2013-10-01 | Apotex Technologies Inc. | Fluorinated derivatives of deferiprone |
| GB0803019D0 (en) * | 2008-02-19 | 2008-03-26 | Btg Int Ltd | Fluorinated compounds |
| PL2268282T3 (pl) | 2008-04-25 | 2015-04-30 | Apotex Tech Inc | Płynny preparat deferypronu o przyjemnym smaku |
| CN103951643B (zh) | 2008-07-25 | 2015-12-09 | 盐野义制药株式会社 | 用作hiv整合酶抑制剂的化合物 |
| KR101678563B1 (ko) | 2008-12-11 | 2016-11-22 | 비이브 헬쓰케어 컴퍼니 | 카르바모일피리돈 ｈｉｖ 인테그라제 억제제를 위한 제조방법 및 중간체 |
| KR101733625B1 (ko) | 2008-12-11 | 2017-05-10 | 시오노기세야쿠 가부시키가이샤 | 카르바모일피리돈 ｈｉｖ 인테그라제 억제제 및 중간체의 합성 |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| ME01911B (me) | 2009-07-03 | 2014-12-20 | Apotex Tech Inc | Fluorisani derivati 3-hidroksipiridin-4-ona |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| CN109438405B (zh) * | 2018-12-24 | 2023-04-07 | 广东莱佛士制药技术有限公司 | 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法 |
| WO2020132820A1 (zh) * | 2018-12-24 | 2020-07-02 | 广东莱佛士制药技术有限公司 | 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法 |
| CN111606879A (zh) * | 2020-05-25 | 2020-09-01 | 安徽金禾实业股份有限公司 | 一锅法制备2-羟甲基-3-烷氧基-4h-吡喃-4-酮的方法 |
| CN114736155B (zh) * | 2021-03-10 | 2023-12-05 | 浙江工业大学 | Ala杂合3-羟基吡啶酮衍生物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518098A1 (de) * | 1963-09-19 | 1969-04-10 | Pfizer & Co C | Verfahren zur Herstellung von Pyromekonsaeurederivaten |
| US3468915A (en) * | 1966-04-18 | 1969-09-23 | Pfizer & Co C | Novel 2-substituted-6-methylpyromeconic acids |
| JPS5921954B2 (ja) * | 1980-02-13 | 1984-05-23 | 新日本製鐵株式会社 | 鋼材の防錆処理方法 |
| US5112968A (en) * | 1989-07-28 | 1992-05-12 | E. R. Squibb & Sons, Inc. | Monobactam hydrazide derivatives |
| GB9006522D0 (en) * | 1990-03-23 | 1990-05-23 | Hider Robert C | Metal complexes |
| ES2244967T3 (es) * | 1995-09-29 | 2005-12-16 | Novartis Ag | Nuevas hidroxipiridinonas. |
-
1997
- 1997-05-29 GB GBGB9711093.6A patent/GB9711093D0/en not_active Ceased
-
1998
- 1998-05-26 AT AT98922968T patent/ATE230728T1/de not_active IP Right Cessation
- 1998-05-26 JP JP50036299A patent/JP2002500663A/ja not_active Ceased
- 1998-05-26 WO PCT/GB1998/001517 patent/WO1998054138A1/en not_active Ceased
- 1998-05-26 AU AU75427/98A patent/AU751600B2/en not_active Ceased
- 1998-05-26 EP EP98922968A patent/EP0984934B1/en not_active Expired - Lifetime
- 1998-05-26 CA CA002287907A patent/CA2287907C/en not_active Expired - Fee Related
- 1998-05-26 DE DE69810619T patent/DE69810619T2/de not_active Expired - Fee Related
- 1998-05-26 DK DK98922968T patent/DK0984934T3/da active
- 1998-05-26 ES ES98922968T patent/ES2187025T3/es not_active Expired - Lifetime
- 1998-05-29 ZA ZA9804635A patent/ZA984635B/xx unknown
-
1999
- 1999-11-10 US US09/437,211 patent/US6335353B1/en not_active Expired - Lifetime
-
2001
- 2001-09-04 US US09/944,113 patent/US6506911B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998054138A1 (en) | 1998-12-03 |
| DK0984934T3 (da) | 2003-05-05 |
| DE69810619T2 (de) | 2003-09-25 |
| US6335353B1 (en) | 2002-01-01 |
| US6506911B2 (en) | 2003-01-14 |
| CA2287907A1 (en) | 1998-12-03 |
| EP0984934B1 (en) | 2003-01-08 |
| EP0984934A1 (en) | 2000-03-15 |
| US20020068758A1 (en) | 2002-06-06 |
| ATE230728T1 (de) | 2003-01-15 |
| ES2187025T3 (es) | 2003-05-16 |
| AU751600B2 (en) | 2002-08-22 |
| CA2287907C (en) | 2009-01-13 |
| AU7542798A (en) | 1998-12-30 |
| JP2002500663A (ja) | 2002-01-08 |
| GB9711093D0 (en) | 1997-07-23 |
| DE69810619D1 (de) | 2003-02-13 |
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