ATE230728T1 - Oral aktive eisen (iii) chelatoren - Google Patents
Oral aktive eisen (iii) chelatorenInfo
- Publication number
- ATE230728T1 ATE230728T1 AT98922968T AT98922968T ATE230728T1 AT E230728 T1 ATE230728 T1 AT E230728T1 AT 98922968 T AT98922968 T AT 98922968T AT 98922968 T AT98922968 T AT 98922968T AT E230728 T1 ATE230728 T1 AT E230728T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- aryl
- group
- aralkyl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9711093.6A GB9711093D0 (en) | 1997-05-29 | 1997-05-29 | Novel orally active iron (III) chelators |
PCT/GB1998/001517 WO1998054138A1 (en) | 1997-05-29 | 1998-05-26 | Novel orally active iron (iii) chelators |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE230728T1 true ATE230728T1 (de) | 2003-01-15 |
Family
ID=10813233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98922968T ATE230728T1 (de) | 1997-05-29 | 1998-05-26 | Oral aktive eisen (iii) chelatoren |
Country Status (12)
Country | Link |
---|---|
US (2) | US6335353B1 (de) |
EP (1) | EP0984934B1 (de) |
JP (1) | JP2002500663A (de) |
AT (1) | ATE230728T1 (de) |
AU (1) | AU751600B2 (de) |
CA (1) | CA2287907C (de) |
DE (1) | DE69810619T2 (de) |
DK (1) | DK0984934T3 (de) |
ES (1) | ES2187025T3 (de) |
GB (1) | GB9711093D0 (de) |
WO (1) | WO1998054138A1 (de) |
ZA (1) | ZA984635B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100075503A (ko) | 1999-10-01 | 2010-07-02 | 디엠아이 바이오사이언시스, 인크 | 금속 결합 화합물 및 그의 용도 |
US6426418B1 (en) | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
EP1474396B9 (de) | 2002-02-05 | 2008-07-09 | Bristol-Myers Squibb Company | N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika |
EP1565185A4 (de) | 2002-11-07 | 2011-01-05 | Technion Res & Dev Foundation | Neuroprotektive eisenchelatoren und pharmazeutische zusammensetzungen damit |
NZ529657A (en) * | 2003-11-20 | 2004-07-30 | Apotex Inc | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
CA2488034C (en) * | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
GB0506677D0 (en) * | 2005-04-01 | 2005-05-11 | Btg Int Ltd | Iron modulators |
US8026261B2 (en) * | 2007-03-28 | 2011-09-27 | Apotex Technologies Inc. | Fluorinated derivatives of deferiprone |
GB0803019D0 (en) * | 2008-02-19 | 2008-03-26 | Btg Int Ltd | Fluorinated compounds |
DK2268282T3 (en) | 2008-04-25 | 2014-11-24 | Apotex Technologies Inc | Liquid formulation of deferiprone with pleasant taste |
KR101695807B1 (ko) | 2008-07-25 | 2017-01-13 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
ES2763540T3 (es) | 2008-12-11 | 2020-05-29 | Viiv Healthcare Co | Intermedios para inhibidores de la integrasa del VIH de carbamoilpiridona |
US8624023B2 (en) | 2008-12-11 | 2014-01-07 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
SI2448922T1 (sl) | 2009-07-03 | 2014-12-31 | Apotex Technologies Inc. | Fluorirani derivati 3-hidroksipiridin-4-onov |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
WO2020132820A1 (zh) * | 2018-12-24 | 2020-07-02 | 广东莱佛士制药技术有限公司 | 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法 |
CN109438405B (zh) * | 2018-12-24 | 2023-04-07 | 广东莱佛士制药技术有限公司 | 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法 |
CN111606879A (zh) * | 2020-05-25 | 2020-09-01 | 安徽金禾实业股份有限公司 | 一锅法制备2-羟甲基-3-烷氧基-4h-吡喃-4-酮的方法 |
CN113121423B (zh) * | 2021-03-10 | 2022-07-22 | 浙江工业大学 | Ala杂合3-羟基吡啶酮衍生物及其制备方法与应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1518098A1 (de) * | 1963-09-19 | 1969-04-10 | Pfizer & Co C | Verfahren zur Herstellung von Pyromekonsaeurederivaten |
US3468915A (en) * | 1966-04-18 | 1969-09-23 | Pfizer & Co C | Novel 2-substituted-6-methylpyromeconic acids |
JPS5921954B2 (ja) * | 1980-02-13 | 1984-05-23 | 新日本製鐵株式会社 | 鋼材の防錆処理方法 |
US5112968A (en) * | 1989-07-28 | 1992-05-12 | E. R. Squibb & Sons, Inc. | Monobactam hydrazide derivatives |
GB9006522D0 (en) * | 1990-03-23 | 1990-05-23 | Hider Robert C | Metal complexes |
PT768302E (pt) * | 1995-09-29 | 2005-11-30 | Novartis Ag | Novas hidroxipiridinonas |
-
1997
- 1997-05-29 GB GBGB9711093.6A patent/GB9711093D0/en not_active Ceased
-
1998
- 1998-05-26 ES ES98922968T patent/ES2187025T3/es not_active Expired - Lifetime
- 1998-05-26 CA CA002287907A patent/CA2287907C/en not_active Expired - Fee Related
- 1998-05-26 WO PCT/GB1998/001517 patent/WO1998054138A1/en active IP Right Grant
- 1998-05-26 AT AT98922968T patent/ATE230728T1/de not_active IP Right Cessation
- 1998-05-26 EP EP98922968A patent/EP0984934B1/de not_active Expired - Lifetime
- 1998-05-26 JP JP50036299A patent/JP2002500663A/ja not_active Ceased
- 1998-05-26 DE DE69810619T patent/DE69810619T2/de not_active Expired - Fee Related
- 1998-05-26 AU AU75427/98A patent/AU751600B2/en not_active Ceased
- 1998-05-26 DK DK98922968T patent/DK0984934T3/da active
- 1998-05-29 ZA ZA9804635A patent/ZA984635B/xx unknown
-
1999
- 1999-11-10 US US09/437,211 patent/US6335353B1/en not_active Expired - Lifetime
-
2001
- 2001-09-04 US US09/944,113 patent/US6506911B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU7542798A (en) | 1998-12-30 |
DE69810619D1 (de) | 2003-02-13 |
GB9711093D0 (en) | 1997-07-23 |
WO1998054138A1 (en) | 1998-12-03 |
CA2287907A1 (en) | 1998-12-03 |
DK0984934T3 (da) | 2003-05-05 |
EP0984934A1 (de) | 2000-03-15 |
AU751600B2 (en) | 2002-08-22 |
EP0984934B1 (de) | 2003-01-08 |
DE69810619T2 (de) | 2003-09-25 |
US6506911B2 (en) | 2003-01-14 |
ZA984635B (en) | 1999-11-29 |
US20020068758A1 (en) | 2002-06-06 |
US6335353B1 (en) | 2002-01-01 |
JP2002500663A (ja) | 2002-01-08 |
CA2287907C (en) | 2009-01-13 |
ES2187025T3 (es) | 2003-05-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE230728T1 (de) | Oral aktive eisen (iii) chelatoren | |
NZ332363A (en) | substituted 4-hydroxy-isoquinoline-3carboxamide derivatives and medicaments | |
ES8307719A1 (es) | "procedimiento de preparar amidoaminoacidos n-substituidos". | |
UA39869C2 (uk) | Похідні аспартаму або їх фізіологічно прийнятні солі, спосіб їх отримання та підсолоджувальна композиція | |
ES477457A1 (es) | Procedimiento de preparacion de amidas de alcohilendiaminas. | |
CA2304713A1 (en) | Biphenyl-5-alkanoic acid derivatives and use thereof | |
GR3031517T3 (en) | RARy-specific retinobenzoic acid derivatives | |
ES482782A1 (es) | Un procedimiento para la preparacion de derivados de imida- zol | |
ATE28187T1 (de) | Polyprenylcarbonsaeureamide und verfahren zu ihrer herstellung. | |
ZA816259B (en) | 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants | |
ES457001A1 (es) | Un procedimiento de preparacion de derivados de fenetilamina. | |
ES8404976A1 (es) | Procedimiento para preparar nuevos derivados de encefalina. | |
ES461785A1 (es) | Un metodo para la preparacion de un ester de acido behenico. | |
ES459186A1 (es) | Un procedimiento para la preparacion de un compuesto de aci-do poliprenilcarboxilico. | |
DE69615657T2 (de) | Antifungal fusacandine | |
PT971899E (pt) | Compostos de hexa-hidroindenopiridina possuindo actividade antiespermatogenica. | |
ES8302734A1 (es) | Procedimiento para preparar 5'-n-(aminoalquil)-amino-5'-deo-xiadenosina | |
IT1268414B1 (it) | Enantiomeri farmacologicamente attivi | |
ES8301199A1 (es) | Procedimiento para la preparacion de un derivado fluorado de diaminobutano que es enlubidor de transaminasa de acido gamma- aminobutirico. | |
MX9302970A (es) | Analogos de acido l-glutamico y gaba para tratamiento anti-ataque. | |
ES465567A1 (es) | Procedimiento para la preparacion de disulfuro de 2-amino- ciclopent-1-en-1tiocarbonilo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0984934 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |