ZA983618B - Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them - Google Patents

Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them

Info

Publication number
ZA983618B
ZA983618B ZA983618A ZA983618A ZA983618B ZA 983618 B ZA983618 B ZA 983618B ZA 983618 A ZA983618 A ZA 983618A ZA 983618 A ZA983618 A ZA 983618A ZA 983618 B ZA983618 B ZA 983618B
Authority
ZA
South Africa
Prior art keywords
contain
preparation
pharmaceutical compositions
cyclosporin derivatives
novel cyclosporin
Prior art date
Application number
ZA983618A
Other languages
English (en)
Inventor
Michel Evers
Jean-Christophe Carry
Georges Bashiardes
Jean-Christophe Gueguen
Serge Mignani
Bruno Filoche
Claude Bensoussan
Jean-Claude Barriere
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ZA983618B publication Critical patent/ZA983618B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA983618A 1997-04-30 1998-04-29 Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them ZA983618B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9705351A FR2762843B1 (fr) 1997-04-30 1997-04-30 Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA983618B true ZA983618B (en) 1998-11-04

Family

ID=9506467

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983618A ZA983618B (en) 1997-04-30 1998-04-29 Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them

Country Status (13)

Country Link
US (1) US5977067A (xx)
EP (1) EP0979244B1 (xx)
JP (1) JP2001524105A (xx)
AT (1) ATE290015T1 (xx)
AU (1) AU7535798A (xx)
DE (1) DE69829175T2 (xx)
ES (1) ES2236902T3 (xx)
FR (1) FR2762843B1 (xx)
MA (1) MA26488A1 (xx)
PT (1) PT979244E (xx)
TN (1) TNSN98057A1 (xx)
WO (1) WO1998049193A1 (xx)
ZA (1) ZA983618B (xx)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
PL210795B1 (pl) 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247
NZ531946A (en) * 2001-10-19 2005-09-30 Isotechnika Inc Preconcentrate formulations comprising cyclosporin analogue microemulsions that reduce adverse effects while maintaining high bioavailability
KR20040039622A (ko) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
ES2347144T3 (es) * 2002-08-30 2010-10-26 Biorexis Pharmaceutical Corporation Proteinas de fusion de la transferrina modificada que comprenden dominos aino o carboxilo de transferrina duplicados.
DE602004030105D1 (de) * 2003-05-05 2010-12-30 Virxsys Corp Erhöhte transduktion mit abc-transportersubstratenhemmern
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
CN101773661B (zh) * 2004-10-01 2013-09-25 西尼克斯公司 用于治疗和预防丙型肝炎病毒感染的3-醚和3-硫醚取代的环孢菌素衍生物
CN101316859A (zh) * 2005-09-30 2008-12-03 西尼克斯公司 用于治疗和预防病毒感染的环孢菌素a的芳基烷基和杂芳基烷基衍生物
BRPI0616476A2 (pt) * 2005-09-30 2011-06-21 Scynexis Inc uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
CA2625700A1 (en) * 2005-10-14 2007-04-26 Allergan, Inc. Prevention and treatment of drug-associated ocular side effects with a cyclosporin
AU2007254148B2 (en) 2006-05-19 2013-02-07 Scynexis, Inc. Method for the treatment and prevention of ocular disorders
KR101089112B1 (ko) * 2006-06-02 2011-12-06 피씨 제스띠옹 에스.아.에스. 활성 전자 관리
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
WO2010002428A2 (en) 2008-06-06 2010-01-07 Scynexis, Inc. Novel macrocyclic peptides
CN102164948A (zh) * 2008-07-30 2011-08-24 伊索技术制药公司 非免疫抑制的环孢菌素类似分子
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
US8536114B2 (en) 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
WO2010088573A1 (en) 2009-01-30 2010-08-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
WO2010138422A1 (en) * 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for enhancing the growth of hair
AU2010254316A1 (en) * 2009-05-27 2011-12-22 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US20120010131A1 (en) * 2009-12-30 2012-01-12 Scynexis, Inc. Novel cyclosporin analogues
BR112013008864A2 (pt) 2010-10-12 2016-06-28 Allergan Inc análogos d ciclosporina
WO2012051193A1 (en) 2010-10-12 2012-04-19 Allergan, Inc. Cyclosporin analogs
SG191069A1 (en) 2010-12-15 2013-07-31 Isotechnika Pharma Inc Cyclosporine analogue molecules modified at amino acid 1 and 3
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
EP2705856A1 (en) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Compounds for the treatment of neurodegenerative disorders
WO2014049540A2 (en) 2012-09-29 2014-04-03 Novartis Ag Cyclic peptides and use as medicines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
US4885276A (en) * 1987-06-03 1989-12-05 Merck & Co., Inc. Cyclosporin analogs with modified "C-9 amino acids"
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
SK278808B6 (sk) * 1990-11-02 1998-03-04 Novartis Ag Cyklosporíny, ich použitie pri príprave liečiva na
US5512555A (en) * 1994-07-21 1996-04-30 Merck & Co., Inc. Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one
AU722858B2 (en) * 1995-07-17 2000-08-10 Scynexis, Inc. Cyclosporin derivatives having an anti-HIV effect

Also Published As

Publication number Publication date
PT979244E (pt) 2005-06-30
ATE290015T1 (de) 2005-03-15
FR2762843B1 (fr) 1999-12-10
US5977067A (en) 1999-11-02
DE69829175D1 (de) 2005-04-07
MA26488A1 (fr) 2004-12-20
FR2762843A1 (fr) 1998-11-06
AU7535798A (en) 1998-11-24
JP2001524105A (ja) 2001-11-27
EP0979244B1 (fr) 2005-03-02
DE69829175T2 (de) 2006-02-16
TNSN98057A1 (fr) 2005-03-15
EP0979244A1 (fr) 2000-02-16
ES2236902T3 (es) 2005-07-16
WO1998049193A1 (fr) 1998-11-05

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