ZA982927B - Novel process for the preparation of (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-01, or cericlamine (inn). - Google Patents

Novel process for the preparation of (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-01, or cericlamine (inn).

Info

Publication number
ZA982927B
ZA982927B ZA9802927A ZA982927A ZA982927B ZA 982927 B ZA982927 B ZA 982927B ZA 9802927 A ZA9802927 A ZA 9802927A ZA 982927 A ZA982927 A ZA 982927A ZA 982927 B ZA982927 B ZA 982927B
Authority
ZA
South Africa
Prior art keywords
dichlorophenyl
dimethylamino
pct
acid
cericlamine
Prior art date
Application number
ZA9802927A
Other languages
English (en)
Inventor
Marc Nicolas
Blandine Laboue
Dominique Depernet
Original Assignee
Parke Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis filed Critical Parke Davis
Publication of ZA982927B publication Critical patent/ZA982927B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA9802927A 1997-04-07 1998-04-06 Novel process for the preparation of (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-01, or cericlamine (inn). ZA982927B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9704311A FR2761686B1 (fr) 1997-04-07 1997-04-07 Nouveau procede de preparation du (+/-)3-(3,4- dichlorophenyl)-2-dimethylamino-2-methyl-propan-1-ol ou cericlamine (inn)

Publications (1)

Publication Number Publication Date
ZA982927B true ZA982927B (en) 1999-07-15

Family

ID=9505666

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9802927A ZA982927B (en) 1997-04-07 1998-04-06 Novel process for the preparation of (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-01, or cericlamine (inn).

Country Status (21)

Country Link
US (1) US6121491A (fr)
EP (1) EP0973724B1 (fr)
JP (1) JP2001519799A (fr)
KR (1) KR20010006073A (fr)
AT (1) ATE251116T1 (fr)
AU (1) AU728636B2 (fr)
BR (1) BR9811459A (fr)
CA (1) CA2277874A1 (fr)
DE (1) DE69818653T2 (fr)
DK (1) DK0973724T3 (fr)
EA (1) EA004399B1 (fr)
ES (1) ES2209137T3 (fr)
FR (1) FR2761686B1 (fr)
HU (1) HUP0001753A3 (fr)
IL (1) IL130813A (fr)
NZ (1) NZ337588A (fr)
PL (1) PL336041A1 (fr)
PT (1) PT973724E (fr)
SK (1) SK284184B6 (fr)
WO (1) WO1998045248A1 (fr)
ZA (1) ZA982927B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1691811B1 (fr) 2003-12-11 2014-07-23 Sunovion Pharmaceuticals Inc. Combinaison d'un sedatif et d'un modulateur des neurotransmetteurs, et methodes permettant d'ameliorer la qualite du sommeil et de traiter la depression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2378746A1 (fr) * 1977-01-28 1978-08-25 Synthelabo Derives d'acides a-amines
JPS6078921A (ja) * 1983-10-05 1985-05-04 Toyo Soda Mfg Co Ltd ハロゲン含有エチルベンゼン誘導体の製造方法
JPS61204150A (ja) * 1985-03-08 1986-09-10 Sagami Chem Res Center α―ハロ―α―トリフルオロメチル―β―アリールプロピオン酸
FR2593499B1 (fr) * 1986-01-30 1988-08-12 Jouveinal Sa Aminoalcools, leur procede de preparation et leurs applications, notamment en therapeutique
US5472970A (en) * 1992-05-05 1995-12-05 Institut De Recherche Jouveinal S.A. Allylaminoesters and their application in therapeutics
FR2690916B1 (fr) * 1992-05-05 1994-06-17 Jouveinal Inst Rech Nouveaux enantiomeres derives du (s)-amino-2-(dichloro-3,4-benzyl)-2-propanol-1.

Also Published As

Publication number Publication date
EA199900906A1 (ru) 2000-08-28
IL130813A0 (en) 2001-01-28
EA004399B1 (ru) 2004-04-29
BR9811459A (pt) 2000-09-19
AU7525998A (en) 1998-10-30
HUP0001753A2 (hu) 2000-11-28
WO1998045248A1 (fr) 1998-10-15
ATE251116T1 (de) 2003-10-15
JP2001519799A (ja) 2001-10-23
EP0973724A1 (fr) 2000-01-26
CA2277874A1 (fr) 1998-10-15
PT973724E (pt) 2004-02-27
ES2209137T3 (es) 2004-06-16
SK136099A3 (en) 2000-05-16
US6121491A (en) 2000-09-19
FR2761686A1 (fr) 1998-10-09
KR20010006073A (ko) 2001-01-15
IL130813A (en) 2003-07-06
DE69818653D1 (de) 2003-11-06
NZ337588A (en) 2000-05-26
HUP0001753A3 (en) 2000-12-28
PL336041A1 (en) 2000-06-05
AU728636B2 (en) 2001-01-11
DE69818653T2 (de) 2004-08-19
SK284184B6 (sk) 2004-10-05
DK0973724T3 (da) 2004-02-02
FR2761686B1 (fr) 1999-05-14
EP0973724B1 (fr) 2003-10-01

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