ZA981936B - Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase. - Google Patents

Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.

Info

Publication number
ZA981936B
ZA981936B ZA9801936A ZA981936A ZA981936B ZA 981936 B ZA981936 B ZA 981936B ZA 9801936 A ZA9801936 A ZA 9801936A ZA 981936 A ZA981936 A ZA 981936A ZA 981936 B ZA981936 B ZA 981936B
Authority
ZA
South Africa
Prior art keywords
fructose
bisphosphatase
novel benzimidazole
benzimidazole inhibitors
inhibitors
Prior art date
Application number
ZA9801936A
Other languages
English (en)
Inventor
Srinivas Rao Kasibhatla
K Raja Reddy
Mark D Erion
Qun Dang
Gerard R Scarlato
M Rami Reddy
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of ZA981936B publication Critical patent/ZA981936B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9801936A 1997-03-07 1998-03-06 Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase. ZA981936B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4062797P 1997-03-07 1997-03-07

Publications (1)

Publication Number Publication Date
ZA981936B true ZA981936B (en) 1999-09-06

Family

ID=21912034

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9801936A ZA981936B (en) 1997-03-07 1998-03-06 Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.

Country Status (11)

Country Link
US (2) US6110903A (https=)
EP (1) EP0970095B1 (https=)
JP (1) JP2001515482A (https=)
AT (1) ATE253073T1 (https=)
AU (1) AU6691498A (https=)
DE (1) DE69819311T2 (https=)
DK (1) DK0970095T3 (https=)
ES (1) ES2210728T3 (https=)
PT (1) PT970095E (https=)
WO (1) WO1998039343A1 (https=)
ZA (1) ZA981936B (https=)

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DK0970095T3 (da) 2004-03-08
US6399782B1 (en) 2002-06-04
EP0970095A1 (en) 2000-01-12
US6110903A (en) 2000-08-29
ES2210728T3 (es) 2004-07-01
ATE253073T1 (de) 2003-11-15
WO1998039343A1 (en) 1998-09-11
JP2001515482A (ja) 2001-09-18
EP0970095B1 (en) 2003-10-29
PT970095E (pt) 2004-03-31
DE69819311D1 (de) 2003-12-04
DE69819311T2 (de) 2004-07-29
AU6691498A (en) 1998-09-22

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