ZA9811130B - Novel bispidine antiarrhythmic compounds - Google Patents

Novel bispidine antiarrhythmic compounds

Info

Publication number
ZA9811130B
ZA9811130B ZA9811130A ZA9811130A ZA9811130B ZA 9811130 B ZA9811130 B ZA 9811130B ZA 9811130 A ZA9811130 A ZA 9811130A ZA 9811130 A ZA9811130 A ZA 9811130A ZA 9811130 B ZA9811130 B ZA 9811130B
Authority
ZA
South Africa
Prior art keywords
antiarrhythmic compounds
bispidine
novel
novel bispidine
antiarrhythmic
Prior art date
Application number
ZA9811130A
Other languages
English (en)
Inventor
Christer Alstermark
Kurt-Juergen Hoffmann
Annika Bjoere
Eva-Lotte Lindstedt
Magnus Bjoersne
Magnus Polla
Marianne Frantsi
Gert Strandlund
Torbjoern Halvarsson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of ZA9811130B publication Critical patent/ZA9811130B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9811130A 1997-12-17 1998-12-04 Novel bispidine antiarrhythmic compounds ZA9811130B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9704709A SE9704709D0 (sv) 1997-12-17 1997-12-17 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
ZA9811130B true ZA9811130B (en) 1999-06-17

Family

ID=20409426

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9811130A ZA9811130B (en) 1997-12-17 1998-12-04 Novel bispidine antiarrhythmic compounds

Country Status (28)

Country Link
US (1) US6291475B1 (sk)
EP (1) EP1047695B1 (sk)
JP (1) JP2002508375A (sk)
KR (1) KR20010024723A (sk)
CN (1) CN1284956A (sk)
AR (1) AR017217A1 (sk)
AT (1) ATE261964T1 (sk)
AU (1) AU1795399A (sk)
BR (1) BR9813668A (sk)
CA (1) CA2314490A1 (sk)
DE (1) DE69822513T2 (sk)
DK (1) DK1047695T3 (sk)
EE (1) EE200000365A (sk)
ES (1) ES2216337T3 (sk)
HU (1) HUP0102307A3 (sk)
ID (1) ID24638A (sk)
IL (1) IL136374A0 (sk)
IS (1) IS5522A (sk)
NO (1) NO20003137L (sk)
NZ (1) NZ504909A (sk)
PL (1) PL341388A1 (sk)
PT (1) PT1047695E (sk)
SE (1) SE9704709D0 (sk)
SI (1) SI1047695T1 (sk)
SK (1) SK7812000A3 (sk)
TR (1) TR200001757T2 (sk)
WO (1) WO1999031100A1 (sk)
ZA (1) ZA9811130B (sk)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
US20050004113A1 (en) * 1999-06-16 2005-01-06 Astrazeneca Ab New bispidine compounds useful in the treatment of cardiac arrhythmias
SE9902268D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
US20040229900A1 (en) * 1999-06-16 2004-11-18 Astrazeneca Ab Bispidine compounds useful in the treatment of cardiac arrythmias
SE9902269D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9902271D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
US7038054B1 (en) * 1999-09-03 2006-05-02 Pharmacopeia Drug Discovery, Inc. Diazabicyclononane scaffold for combinatorial synthesis
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AU1996301A (en) 1999-12-14 2001-06-25 Neurosearch A/S Novel heteroaryl-diazabicycloalkanes
SE9904765D0 (sv) 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030302A1 (es) * 2000-07-07 2003-08-20 Astrazeneca Ab Compuestos de bispidina, formulacion farmaceutica, uso para la fabricacion de medicamentos, proceso para la preparacion de estos compuestos y compuestos intermediarios
SE0002603D0 (sv) * 2000-07-07 2000-07-07 Astrazeneca Ab New compounds
US6808924B1 (en) 2000-07-11 2004-10-26 Claudia Lanari Mouse mammary tumor lines expressing estrogen and progesterone receptors
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
SE0100326D0 (sv) 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
WO2002096911A1 (en) * 2001-06-01 2002-12-05 Neurosearch A/S Novel heteroaryl-diazabicyclo-alkanes as cns-modulators
TW200418468A (en) * 2002-11-18 2004-10-01 Solvay Pharm Gmbh Liquid pharmaceutical formulations containing 3,7-diazabicyclo[3,3,1]nonane compounds and method of treatments relating to anti-arrhytmic events
WO2005095401A1 (en) * 2004-03-22 2005-10-13 Boehringer Ingelheim Pharmaceuticals, Inc. Alpha-trifluoromethyl alcohols or amines as glucocorticoid mimetics
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
AR057064A1 (es) 2005-06-13 2007-11-14 Astrazeneca Ab Compuestos para el tratamiento de arritmias cardiacas, formulacion farmaceutica y preparacion del compuesto
CN102485725B (zh) * 2010-12-02 2015-07-22 武汉药明康德新药开发有限公司 一种双氮杂环桥环类药物模板及其制备方法和应用
WO2012172043A1 (en) 2011-06-15 2012-12-20 Laboratoire Biodim Purine derivatives and their use as pharmaceuticals for prevention or treatment of bacterial infections
CN102875550B (zh) * 2011-07-12 2016-01-06 常州合全药业有限公司 1,3,7-三取代-3,7-二氮杂双环[3,3,1]壬烷衍生物及制备方法
CN104151277A (zh) * 2014-06-30 2014-11-19 北京万全德众医药生物技术有限公司 盐酸决奈达隆一种氧化杂质的制备方法
CN113683585B (zh) * 2021-09-26 2023-07-11 齐鲁工业大学 一种含环氧基邻苯二甲腈单体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2428792A1 (de) 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
PT88381B (pt) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
FR2713081B1 (fr) 1993-11-29 1996-01-12 Celsa Lg Filtre sanguin perfectionné à deux séries de pattes en pétales.

Also Published As

Publication number Publication date
HUP0102307A2 (hu) 2001-12-28
ID24638A (id) 2000-07-27
JP2002508375A (ja) 2002-03-19
KR20010024723A (ko) 2001-03-26
TR200001757T2 (tr) 2000-09-21
PT1047695E (pt) 2004-07-30
NO20003137L (no) 2000-08-17
EP1047695B1 (en) 2004-03-17
CN1284956A (zh) 2001-02-21
BR9813668A (pt) 2000-10-17
SK7812000A3 (en) 2001-05-10
ATE261964T1 (de) 2004-04-15
HUP0102307A3 (en) 2002-02-28
IL136374A0 (en) 2001-06-14
US6291475B1 (en) 2001-09-18
NZ504909A (en) 2001-11-30
DE69822513D1 (de) 2004-04-22
ES2216337T3 (es) 2004-10-16
IS5522A (is) 2000-06-02
SI1047695T1 (en) 2004-08-31
SE9704709D0 (sv) 1997-12-17
EP1047695A1 (en) 2000-11-02
CA2314490A1 (en) 1999-06-24
NO20003137D0 (no) 2000-06-16
PL341388A1 (en) 2001-04-09
DK1047695T3 (da) 2004-06-28
DE69822513T2 (de) 2005-03-10
EE200000365A (et) 2001-10-15
WO1999031100A1 (en) 1999-06-24
AR017217A1 (es) 2001-08-22
AU1795399A (en) 1999-07-05

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