ZA9711035B - Preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl)methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxamide. - Google Patents

Preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl)methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxamide.

Info

Publication number
ZA9711035B
ZA9711035B ZA9711035A ZA9711035A ZA9711035B ZA 9711035 B ZA9711035 B ZA 9711035B ZA 9711035 A ZA9711035 A ZA 9711035A ZA 9711035 A ZA9711035 A ZA 9711035A ZA 9711035 B ZA9711035 B ZA 9711035B
Authority
ZA
South Africa
Prior art keywords
dihydroxycyclopentanecarboxamide
imidazo
pyridin
thienyl
chloro
Prior art date
Application number
ZA9711035A
Other languages
English (en)
Inventor
Michael K O Brien
Herve Garcia
Patrick Leon
Tory H Powner
Laurence W Reilly
Shah C Harshavadan
Michael D Thompson
Ching T Tsuei
Benoit J Vanesse
Francis L Walther
Original Assignee
Rhone Poulenc Rorer Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma
Publication of ZA9711035B publication Critical patent/ZA9711035B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
ZA9711035A 1996-12-11 1997-12-09 Preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl)methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxamide. ZA9711035B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3276496P 1996-12-11 1996-12-11

Publications (1)

Publication Number Publication Date
ZA9711035B true ZA9711035B (en) 1998-06-15

Family

ID=21866680

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9711035A ZA9711035B (en) 1996-12-11 1997-12-09 Preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl)methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxamide.

Country Status (27)

Country Link
US (2) US6143894A (fr)
EP (2) EP0946550B1 (fr)
JP (1) JP2001506626A (fr)
KR (4) KR20060002030A (fr)
CN (3) CN1191251C (fr)
AP (1) AP1063A (fr)
AT (1) ATE301120T1 (fr)
AU (1) AU738581B2 (fr)
BG (1) BG63805B1 (fr)
BR (1) BR9713705A (fr)
CA (1) CA2274630C (fr)
DE (1) DE69733897T2 (fr)
DK (1) DK0946550T3 (fr)
EA (1) EA001989B1 (fr)
ES (1) ES2242984T3 (fr)
HK (2) HK1023998A1 (fr)
HU (1) HUP0000342A3 (fr)
IL (1) IL130397A (fr)
MX (1) MXPA03006730A (fr)
NO (2) NO319722B1 (fr)
OA (1) OA11061A (fr)
PT (1) PT946550E (fr)
SI (1) SI0946550T1 (fr)
SK (1) SK71199A3 (fr)
UA (1) UA54479C2 (fr)
WO (1) WO1998025921A1 (fr)
ZA (1) ZA9711035B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2228163T3 (es) 1998-12-31 2005-04-01 Aventis Pharmaceuticals Inc. Procedimiento para preparar derivados de desaza-adenosina n6-sustituidos.
US7291603B2 (en) * 2002-07-24 2007-11-06 Ptc Therapeutics, Inc. Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
FR2846656B1 (fr) * 2002-11-05 2004-12-24 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2095960T3 (es) * 1990-09-25 1997-03-01 Rhone Poulenc Rorer Int Compuestos que tienen propiedades antihipertensivas y antiisquemicas.
HUP0100179A3 (en) * 1997-07-03 2002-12-28 Bristol Myers Squibb Pharma Co Imidazopyrimidine and imidazopyridine derivatives and pharmaceutical compositions thereof
CZ20012283A3 (cs) * 1998-12-21 2001-10-17 Aventis Pharmaceuticals Products Inc. Způsob přípravy derivátů deaza-adenosinů substituovaných v poloze N6

Also Published As

Publication number Publication date
AU5360798A (en) 1998-07-03
OA11061A (en) 2002-02-27
DE69733897D1 (de) 2005-09-08
SI0946550T1 (en) 2005-10-31
ATE301120T1 (de) 2005-08-15
CN1240445A (zh) 2000-01-05
BR9713705A (pt) 2000-05-09
NO20052327L (no) 1999-08-10
HK1023998A1 (en) 2000-09-29
CN1090630C (zh) 2002-09-11
EP0946550A4 (fr) 2003-05-14
IL130397A0 (en) 2000-06-01
EP0946550A1 (fr) 1999-10-06
KR20050046793A (ko) 2005-05-18
JP2001506626A (ja) 2001-05-22
CN1191251C (zh) 2005-03-02
AU738581B2 (en) 2001-09-20
US6235909B1 (en) 2001-05-22
DK0946550T3 (da) 2005-08-29
KR100510389B1 (ko) 2005-08-31
CN1394859A (zh) 2003-02-05
ES2242984T3 (es) 2005-11-16
CA2274630C (fr) 2000-10-03
HUP0000342A2 (hu) 2000-10-28
NO319722B1 (no) 2005-09-05
PT946550E (pt) 2005-09-30
DE69733897T2 (de) 2006-06-01
IL130397A (en) 2005-11-20
US6143894A (en) 2000-11-07
NO992795L (no) 1999-08-10
EA001989B1 (ru) 2001-10-22
KR20000057505A (ko) 2000-09-15
KR100571690B1 (ko) 2006-04-18
HUP0000342A3 (en) 2001-01-29
EA199900527A1 (ru) 2000-02-28
AP1063A (en) 2002-04-26
KR20060002029A (ko) 2006-01-06
MXPA03006730A (es) 2003-10-24
BG63805B1 (bg) 2003-01-31
NO992795D0 (no) 1999-06-09
NO20052327D0 (no) 2005-05-12
EP1609791A1 (fr) 2005-12-28
SK71199A3 (en) 2000-07-11
HK1051862A1 (en) 2003-08-22
CN1660842A (zh) 2005-08-31
UA54479C2 (uk) 2003-03-17
AP9901550A0 (en) 1999-06-30
EP0946550B1 (fr) 2005-08-03
BG103484A (en) 2000-06-30
WO1998025921A1 (fr) 1998-06-18
KR20060002030A (ko) 2006-01-06

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