ZA964485B - Piperazine piperidine and 1,2,5,6-tetrahydropridine compounds a process for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Piperazine piperidine and 1,2,5,6-tetrahydropridine compounds a process for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
ZA964485B
ZA964485B ZA964485A ZA964485A ZA964485B ZA 964485 B ZA964485 B ZA 964485B ZA 964485 A ZA964485 A ZA 964485A ZA 964485 A ZA964485 A ZA 964485A ZA 964485 B ZA964485 B ZA 964485B
Authority
ZA
South Africa
Prior art keywords
tetrahydropridine
compounds
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
ZA964485A
Other languages
English (en)
Inventor
Jean-Louis Peglion
Aimee Dessinges
Bertrand Goument
Marc Millan
Adrian Newman-Tancredi
Alain Gobert
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA964485B publication Critical patent/ZA964485B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
ZA964485A 1995-05-31 1996-05-31 Piperazine piperidine and 1,2,5,6-tetrahydropridine compounds a process for the preparation thereof and pharmaceutical compositions containing them ZA964485B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9506436A FR2734819B1 (fr) 1995-05-31 1995-05-31 Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
ZA964485B true ZA964485B (en) 1996-12-12

Family

ID=9479526

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA964485A ZA964485B (en) 1995-05-31 1996-05-31 Piperazine piperidine and 1,2,5,6-tetrahydropridine compounds a process for the preparation thereof and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (2) US5753662A (de)
EP (1) EP0745598B1 (de)
JP (1) JPH08325257A (de)
CN (1) CN1064356C (de)
AT (1) ATE204574T1 (de)
AU (1) AU705374B2 (de)
CA (1) CA2177774C (de)
DE (1) DE69614608T2 (de)
DK (1) DK0745598T3 (de)
ES (1) ES2162989T3 (de)
FR (1) FR2734819B1 (de)
GR (1) GR3037040T3 (de)
NO (1) NO314185B1 (de)
NZ (1) NZ286698A (de)
PT (1) PT745598E (de)
ZA (1) ZA964485B (de)

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DE19637237A1 (de) 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
CA2275299C (en) * 1996-12-20 2003-12-16 H. Lundbeck A/S Indane or dihydroindole derivatives
US6436940B2 (en) 1996-12-20 2002-08-20 H. Lundbeck A/S Indane or dihydroindole derivatives
AU5343498A (en) * 1997-01-21 1998-08-07 Yoshitomi Pharmaceutical Industries, Ltd. Thiophene compounds and medicinal use thereof
FR2760014B1 (fr) * 1997-02-27 1999-04-09 Adir Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2763589B1 (fr) * 1997-05-22 2001-01-05 Centre Nat Rech Scient Composes pour la preparation de medicaments destines au traitement de pathologies impliquant le glutamate extracellulaire, et leurs procedes d'obtention
FR2769312B1 (fr) * 1997-10-03 1999-12-03 Adir Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2308057A1 (en) * 1997-10-24 1999-05-06 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
CA2324268A1 (en) 1998-03-18 1999-09-23 Taisho Pharmaceutical Co., Ltd. Aromaheterocyclic derivatives
US6407121B1 (en) 1998-03-19 2002-06-18 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
EP0953567A3 (de) 1998-04-29 2003-04-02 Pfizer Products Inc. Bizyklisch substituierte Piperazin-, Piperidin- und Tetrahydropyridin Derivate, deren Herstellung und deren Verwendung als Mittel mit zentraler dopaminerger (Dopamin D4 Rezeptor) Aktivität
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
US6177566B1 (en) * 1998-06-30 2001-01-23 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
ATE555102T1 (de) 2001-07-16 2012-05-15 Genzyme Corp N-acylsphingosinglucosyltransferase-inhibitor
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
US7105513B2 (en) * 2002-08-07 2006-09-12 Sanofi-Avertis Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
US6960611B2 (en) 2002-09-16 2005-11-01 Institute Of Materia Medica Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR101431845B1 (ko) * 2006-04-06 2014-08-25 바스프 에스이 개선된 색상 품질을 갖는 ｎ-알킬락탐의 제조 방법
KR20110086869A (ko) * 2008-11-24 2011-08-01 바스프 에스이 개선된 색 품질을 갖는 ｎ-알킬락탐의 제조 방법
WO2010063617A1 (de) 2008-12-04 2010-06-10 Basf Se Mischungen aus itaconsäure oder itaconsäurederivaten und primären aminen zur herstellung von 1,3- und 1,4-alkylmethylpyrrolidonen
WO2010084089A1 (en) 2009-01-22 2010-07-29 Basf Se Mixtures of pvdf, n-alkyllactams and organic carbonate and their applications
US8369001B2 (en) * 2009-07-17 2013-02-05 The United States Of America, As Represented By The Secretary Of The Navy Compact high power terahertz radiation cell
EP3133070B1 (de) 2009-11-27 2019-08-14 Genzyme Corporation Eliglustat (genz 112638) als inhibitor der glucosylceramidsynthase zur verwendung in einem verfahren zur behandlung von fabry's oder gaucher's erkrankung, wobei das verfahren die anpassung der individuellen thearapeutischen dosis an den p-450 stoffwechsel des patienten umfasst
BR122021013836B1 (pt) 2009-12-04 2022-05-24 Sunovion Pharmaceuticals, Inc. Composto e seu uso, composição farmacêutica
JP2019523279A (ja) 2016-07-29 2019-08-22 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 化合物および組成物ならびにそれらの使用
MX2019000980A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
JP7146782B2 (ja) 2017-02-16 2022-10-04 サノビオン ファーマシューティカルズ インク 統合失調症を処置する方法
MX2020000523A (es) 2017-08-02 2020-08-20 Sunovion Pharmaceuticals Inc Compuestos de isocromano y usos de los mismos.
CN118406063A (zh) 2018-02-16 2024-07-30 赛诺维信制药公司 盐、晶型及其制备方法
US11136304B2 (en) 2019-03-14 2021-10-05 Sunovion Pharmaceuticals Inc. Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
MX2022012833A (es) 2020-04-14 2022-11-07 Sunovion Pharmaceuticals Inc (s)-(4,5-dihidro-7h-tieno[2,3-c]piran-7-il)-n-metilmetanamina para tratar trastornos neurologicos y psiquiatricos.

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US3377347A (en) * 1963-06-14 1968-04-09 Ciba Geigy Corp Cyclobutene derivatives
DE2037852C3 (de) * 1970-07-30 1980-06-26 Boehringer Sohn Ingelheim Neue Piperazinderivate und Verfahren zu ihrer Herstellung
US3859438A (en) * 1971-07-08 1975-01-07 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(1-bicyclic aryl-propyl-2)-n-bicyclic aryl-piperazine and method of use
DE4017211A1 (de) * 1990-05-29 1991-12-05 Merck Patent Gmbh Oxazolidinone
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE4127849A1 (de) * 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
DE4321366A1 (de) * 1993-06-26 1995-01-05 Merck Patent Gmbh Piperidine und Piperazine

Also Published As

Publication number Publication date
US5753662A (en) 1998-05-19
EP0745598A1 (de) 1996-12-04
FR2734819A1 (fr) 1996-12-06
CA2177774C (fr) 2001-07-24
FR2734819B1 (fr) 1997-07-04
AU705374B2 (en) 1999-05-20
GR3037040T3 (en) 2002-01-31
CN1142494A (zh) 1997-02-12
PT745598E (pt) 2001-11-30
US5684020A (en) 1997-11-04
NO962210L (no) 1996-12-02
CA2177774A1 (fr) 1996-12-01
ATE204574T1 (de) 2001-09-15
JPH08325257A (ja) 1996-12-10
NZ286698A (en) 1998-02-26
EP0745598B1 (de) 2001-08-22
DE69614608D1 (de) 2001-09-27
NO962210D0 (no) 1996-05-30
DK0745598T3 (da) 2001-10-08
AU5455896A (en) 1996-12-12
ES2162989T3 (es) 2002-01-16
CN1064356C (zh) 2001-04-11
DE69614608T2 (de) 2002-07-04
NO314185B1 (no) 2003-02-10

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