ZA964035B - Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. - Google Patents

Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them.

Info

Publication number
ZA964035B
ZA964035B ZA9604035A ZA964035A ZA964035B ZA 964035 B ZA964035 B ZA 964035B ZA 9604035 A ZA9604035 A ZA 9604035A ZA 964035 A ZA964035 A ZA 964035A ZA 964035 B ZA964035 B ZA 964035B
Authority
ZA
South Africa
Prior art keywords
medicament
fluorophenyl
diagnostic
preparation
alkenylcarboxylic acid
Prior art date
Application number
ZA9604035A
Other languages
English (en)
Inventor
Jan-Robert Schwark
Hans Jochen Lang
Heinz-Werner Kleemann
Andreas Weichert
Wolfgang Scholz
Udo Albus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA964035B publication Critical patent/ZA964035B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9604035A 1995-05-22 1996-05-21 Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. ZA964035B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19518796A DE19518796A1 (de) 1995-05-22 1995-05-22 Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
ZA964035B true ZA964035B (en) 1997-11-21

Family

ID=7762597

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9604035A ZA964035B (en) 1995-05-22 1996-05-21 Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them.

Country Status (29)

Country Link
US (2) US20010020042A1 (no)
EP (1) EP0744397B1 (no)
JP (1) JP3924018B2 (no)
KR (1) KR960041152A (no)
CN (1) CN1063437C (no)
AR (1) AR002744A1 (no)
AT (1) ATE192431T1 (no)
AU (1) AU701493B2 (no)
BR (1) BR9602394A (no)
CA (1) CA2177007C (no)
CZ (1) CZ291622B6 (no)
DE (2) DE19518796A1 (no)
DK (1) DK0744397T3 (no)
ES (1) ES2147629T3 (no)
GR (1) GR3033416T3 (no)
HR (1) HRP960230B1 (no)
HU (1) HUP9601358A3 (no)
IL (1) IL118327A (no)
MY (1) MY113803A (no)
NO (1) NO305552B1 (no)
NZ (1) NZ286622A (no)
PL (1) PL183431B1 (no)
PT (1) PT744397E (no)
RU (1) RU2164913C2 (no)
SI (1) SI0744397T1 (no)
SK (1) SK281527B6 (no)
TR (1) TR199600421A2 (no)
TW (1) TW415936B (no)
ZA (1) ZA964035B (no)

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DE10046993A1 (de) * 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
EP1646371A4 (en) * 2003-06-26 2010-09-22 Biotron Ltd ANTIVIRAL COMPOSITIONS AND METHODS
PL2826770T3 (pl) 2005-06-24 2019-02-28 Biotron Limited Przeciwwirusowe związki acyloguanidynowe
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
KR20200111230A (ko) 2008-12-31 2020-09-28 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 ｎｈｅ-매개된 역수송을 억제하는 화합물 및 방법
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US20150336892A1 (en) 2012-08-21 2015-11-26 Ardelyx, Inc Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
KR102287207B1 (ko) 2013-04-12 2021-08-09 알데릭스, 인코포레이티드 Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법
EP3565808A1 (en) 2017-01-09 2019-11-13 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
CN110291082A (zh) 2017-01-09 2019-09-27 阿德利克斯股份有限公司 Nhe介导的反向转运的抑制剂
EA202090438A1 (ru) 2017-08-04 2020-06-15 Арделикс, Инк. Производные глицерретиновой кислоты для лечения гиперкалиемии
ES2953233T3 (es) 2019-02-07 2023-11-08 Ardelyx Inc Derivados del ácido glicirretínico para su uso en el tratamiento de la hiperpotasemia
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

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Also Published As

Publication number Publication date
JP3924018B2 (ja) 2007-06-06
HUP9601358A2 (en) 1997-05-28
US6504057B2 (en) 2003-01-07
EP0744397B1 (de) 2000-05-03
HRP960230B1 (en) 2000-12-31
CA2177007C (en) 2009-01-06
AU5237396A (en) 1996-12-05
IL118327A (en) 2002-12-01
ATE192431T1 (de) 2000-05-15
HU9601358D0 (en) 1996-07-29
CZ291622B6 (cs) 2003-04-16
US20010020042A1 (en) 2001-09-06
MY113803A (en) 2002-05-31
NZ286622A (en) 1997-08-22
GR3033416T3 (en) 2000-09-29
PL183431B1 (pl) 2002-06-28
US20020123529A1 (en) 2002-09-05
PL314252A1 (en) 1996-11-25
NO962063L (no) 1996-11-25
TR199600421A2 (tr) 1997-03-21
BR9602394A (pt) 1998-10-06
SK65196A3 (en) 1996-12-04
DK0744397T3 (da) 2000-08-28
SK281527B6 (sk) 2001-04-09
ES2147629T3 (es) 2000-09-16
RU2164913C2 (ru) 2001-04-10
DE19518796A1 (de) 1996-11-28
CN1063437C (zh) 2001-03-21
AR002744A1 (es) 1998-04-29
PT744397E (pt) 2000-09-29
CA2177007A1 (en) 1996-11-23
EP0744397A2 (de) 1996-11-27
IL118327A0 (en) 1996-09-12
DE59605101D1 (de) 2000-06-08
JPH08319266A (ja) 1996-12-03
HUP9601358A3 (en) 1997-10-28
TW415936B (en) 2000-12-21
KR960041152A (ko) 1996-12-19
CZ145096A3 (en) 1996-12-11
CN1138029A (zh) 1996-12-18
SI0744397T1 (en) 2000-08-31
NO305552B1 (no) 1999-06-21
AU701493B2 (en) 1999-01-28
NO962063D0 (no) 1996-05-21
EP0744397A3 (de) 1997-03-26
HRP960230A2 (en) 1997-12-31

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