ZA958223B - 2,7-Substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives - Google Patents

2,7-Substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives

Info

Publication number
ZA958223B
ZA958223B ZA958223A ZA958223A ZA958223B ZA 958223 B ZA958223 B ZA 958223B ZA 958223 A ZA958223 A ZA 958223A ZA 958223 A ZA958223 A ZA 958223A ZA 958223 B ZA958223 B ZA 958223B
Authority
ZA
South Africa
Prior art keywords
pct
pyrido
pyrazine derivatives
sec
substituted octahydro
Prior art date
Application number
ZA958223A
Other languages
English (en)
Inventor
Kishor A Desai
Anton F J Fliri
Mark A Sanner
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA958223B publication Critical patent/ZA958223B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA958223A 1994-09-30 1995-09-29 2,7-Substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives ZA958223B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31547094A 1994-09-30 1994-09-30

Publications (1)

Publication Number Publication Date
ZA958223B true ZA958223B (en) 1997-04-01

Family

ID=23224581

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA958223A ZA958223B (en) 1994-09-30 1995-09-29 2,7-Substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives

Country Status (34)

Country Link
US (1) US5852031A (de)
EP (1) EP0783503B1 (de)
JP (1) JP3287574B2 (de)
KR (1) KR100244848B1 (de)
CN (1) CN1068327C (de)
AT (1) ATE209648T1 (de)
AU (1) AU681310B2 (de)
BR (1) BR9504230A (de)
CA (1) CA2200959C (de)
CO (1) CO4410335A1 (de)
CZ (1) CZ285090B6 (de)
DE (1) DE69524241T2 (de)
DK (1) DK0783503T3 (de)
ES (1) ES2166830T3 (de)
FI (1) FI113655B (de)
HR (1) HRP950507B1 (de)
HU (1) HUT77354A (de)
IL (1) IL115384A (de)
MX (1) MX9702350A (de)
MY (1) MY113729A (de)
NO (1) NO308995B1 (de)
NZ (1) NZ290936A (de)
PE (1) PE47196A1 (de)
PL (1) PL180899B1 (de)
PT (1) PT783503E (de)
RU (1) RU2163239C2 (de)
SI (1) SI9520096A (de)
SK (1) SK284341B6 (de)
TR (1) TR199501194A2 (de)
TW (1) TW406081B (de)
UA (1) UA50720C2 (de)
WO (1) WO1996010571A1 (de)
YU (1) YU63795A (de)
ZA (1) ZA958223B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
US6992188B1 (en) 1995-12-08 2006-01-31 Pfizer, Inc. Substituted heterocyclic derivatives
CA2240594C (en) * 1995-12-21 2001-07-24 Pfizer Limited 2,7-substituted octahydro-pyrrolo¬1,2-a|pyrazine derivatives
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0953567A3 (de) 1998-04-29 2003-04-02 Pfizer Products Inc. Bizyklisch substituierte Piperazin-, Piperidin- und Tetrahydropyridin Derivate, deren Herstellung und deren Verwendung als Mittel mit zentraler dopaminerger (Dopamin D4 Rezeptor) Aktivität
GT199900060A (es) * 1998-05-22 2000-10-14 Polimorfos de un monoclorhidrato de pirazina cristalino y sus composiciones farmacèuticas.
GB0010757D0 (en) 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
GB0011013D0 (en) * 2000-05-09 2000-06-28 Astrazeneca Ab Chemical compounds
EP1177792A3 (de) * 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamin-d4-ligande zur behandlung von gaudi-suchenden krankheiten
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
GB0121941D0 (en) 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3564683D1 (en) * 1984-08-07 1988-10-06 Cortial 4-(arylpiperazinylethylaminoethoxy) phenol derivatives, process for their preparation and their therapeutical application
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
IT1204803B (it) * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
ES2072141T3 (es) * 1991-01-31 1995-07-01 Pfizer Resolucion de trans-2-(2-pirimidinil)-7-(hidroximetil)octahidro-2h-pirido(1,2a)pirazina.
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
DK0573464T3 (da) * 1991-02-27 1997-09-01 Pfizer Fremgangsmåde til fremstilling af trans-piperidin-2,5-dicarboxylater
CA2118936A1 (en) * 1991-09-25 1993-04-01 Gene M. Bright Neuroleptic 2-substituted perhydro-1-h-pyrido[1,2-a]pyrazines
ES2137986T3 (es) * 1992-06-16 2000-01-01 Pfizer Procedimiento y productos intermedios para agentes ansioliticos bis-aza-biciclicos.
EP0665840A1 (de) * 1992-10-23 1995-08-09 MERCK SHARP & DOHME LTD. Dopamin-rezeptor subtypliganden
US5631269A (en) * 1992-10-23 1997-05-20 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
US5576319A (en) * 1993-03-01 1996-11-19 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
JPH09500357A (ja) * 1993-03-01 1997-01-14 メルク シヤープ エンド ドーム リミテツド ピロロ−ピリジン誘導体
BR9406128A (pt) * 1993-03-01 1996-02-27 Merck Sharp & Dohme Uso de um composto processo para o tratamento e/ou prevençao de distúrbios psicóticos composto composiçao farmacêutica processos para a preparaçao de um composto e de uma composiçao farmacêutica
EP0687255A1 (de) * 1993-03-05 1995-12-20 MERCK SHARP & DOHME LTD. Chinolone derivate als dopamine d4 liganden
GB9416162D0 (en) * 1994-08-10 1994-09-28 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
CO4410335A1 (es) 1997-01-09
UA50720C2 (uk) 2002-11-15
PT783503E (pt) 2002-03-28
FI971310A0 (fi) 1997-03-27
RU2163239C2 (ru) 2001-02-20
ATE209648T1 (de) 2001-12-15
CA2200959C (en) 2000-05-23
EP0783503A1 (de) 1997-07-16
NO971416D0 (no) 1997-03-25
DE69524241D1 (de) 2002-01-10
NO971416L (no) 1997-05-20
CN1168672A (zh) 1997-12-24
US5852031A (en) 1998-12-22
BR9504230A (pt) 1996-08-06
SK32597A3 (en) 1998-09-09
FI971310A (fi) 1997-03-27
KR970706282A (ko) 1997-11-03
ES2166830T3 (es) 2002-05-01
HRP950507B1 (en) 2002-06-30
DE69524241T2 (de) 2002-06-13
SI9520096A (sl) 1998-04-30
FI113655B (fi) 2004-05-31
NO308995B1 (no) 2000-11-27
SK284341B6 (sk) 2005-02-04
CA2200959A1 (en) 1996-04-11
CZ285090B6 (cs) 1999-05-12
HUT77354A (hu) 1998-03-30
PL319636A1 (en) 1997-08-18
IL115384A (en) 1999-10-28
AU3189395A (en) 1996-04-26
CZ94797A3 (cs) 1998-07-15
KR100244848B1 (ko) 2000-03-02
NZ290936A (en) 1998-01-26
HRP950507A2 (en) 1997-08-31
PE47196A1 (es) 1996-11-11
TR199501194A2 (tr) 1996-06-21
TW406081B (en) 2000-09-21
EP0783503B1 (de) 2001-11-28
DK0783503T3 (da) 2002-02-11
JPH09511527A (ja) 1997-11-18
IL115384A0 (en) 1995-12-31
WO1996010571A1 (en) 1996-04-11
JP3287574B2 (ja) 2002-06-04
AU681310B2 (en) 1997-08-21
YU63795A (sh) 1999-03-04
CN1068327C (zh) 2001-07-11
MX9702350A (es) 1997-06-28
MY113729A (en) 2002-05-31
PL180899B1 (pl) 2001-04-30

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