PE47196A1 - DERIVADO 2,7-SUSTITUIDO DE OCTAHIDRO-1H-PIRIDO[1,2-a]PIRAZINA - Google Patents
DERIVADO 2,7-SUSTITUIDO DE OCTAHIDRO-1H-PIRIDO[1,2-a]PIRAZINAInfo
- Publication number
- PE47196A1 PE47196A1 PE1995279990A PE27999095A PE47196A1 PE 47196 A1 PE47196 A1 PE 47196A1 PE 1995279990 A PE1995279990 A PE 1995279990A PE 27999095 A PE27999095 A PE 27999095A PE 47196 A1 PE47196 A1 PE 47196A1
- Authority
- PE
- Peru
- Prior art keywords
- pct
- pirazina
- octahidro
- pirido
- substituted derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE AL COMPUESTO DE FORMULA I DONDE: Ar ES FENILO, NAFTILO, BENZOXAZOLONILO ENTRE OTROS; Ar1 ES FENILO, PIRIDINILO, PIRIDAZINILO ENTRE OTROS; A ES O, S, SO, ENTRE OTROS; n ES CERO, UNO o DOS, DE PREFERENCIA LOS DOS PRIMEROS ; CADA Ar o Ar1 PUEDE ESTAR INDEPENDIENTE Y OPCIONALMENTE SUSTITUIDO POR UNO A CUATRO SUSTITUYENTES, SELECCIONADOS INDEPENDIENTEMENTE DEL GRUPO CONSISTENTE EN FLUOR, CLORO, BROMO ENTRE OTROS. ES USADO COMO AGENTE DOPAMINERGICO, TENIENDO LA CAPACIDAD DE ALTERAR LA NEUROTRANSMISION MEDIADA POR DOPAMINA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31547094A | 1994-09-30 | 1994-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE47196A1 true PE47196A1 (es) | 1996-11-11 |
Family
ID=23224581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1995279990A PE47196A1 (es) | 1994-09-30 | 1995-09-26 | DERIVADO 2,7-SUSTITUIDO DE OCTAHIDRO-1H-PIRIDO[1,2-a]PIRAZINA |
Country Status (34)
Country | Link |
---|---|
US (1) | US5852031A (es) |
EP (1) | EP0783503B1 (es) |
JP (1) | JP3287574B2 (es) |
KR (1) | KR100244848B1 (es) |
CN (1) | CN1068327C (es) |
AT (1) | ATE209648T1 (es) |
AU (1) | AU681310B2 (es) |
BR (1) | BR9504230A (es) |
CA (1) | CA2200959C (es) |
CO (1) | CO4410335A1 (es) |
CZ (1) | CZ285090B6 (es) |
DE (1) | DE69524241T2 (es) |
DK (1) | DK0783503T3 (es) |
ES (1) | ES2166830T3 (es) |
FI (1) | FI113655B (es) |
HR (1) | HRP950507B1 (es) |
HU (1) | HUT77354A (es) |
IL (1) | IL115384A (es) |
MX (1) | MX9702350A (es) |
MY (1) | MY113729A (es) |
NO (1) | NO308995B1 (es) |
NZ (1) | NZ290936A (es) |
PE (1) | PE47196A1 (es) |
PL (1) | PL180899B1 (es) |
PT (1) | PT783503E (es) |
RU (1) | RU2163239C2 (es) |
SI (1) | SI9520096A (es) |
SK (1) | SK284341B6 (es) |
TR (1) | TR199501194A2 (es) |
TW (1) | TW406081B (es) |
UA (1) | UA50720C2 (es) |
WO (1) | WO1996010571A1 (es) |
YU (1) | YU63795A (es) |
ZA (1) | ZA958223B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6231833B1 (en) * | 1999-08-05 | 2001-05-15 | Pfizer Inc | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors |
US6992188B1 (en) | 1995-12-08 | 2006-01-31 | Pfizer, Inc. | Substituted heterocyclic derivatives |
JP3204456B2 (ja) * | 1995-12-21 | 2001-09-04 | ファイザー・インコーポレーテッド | 2,7―置換オクタヒドロ―ピロロ[1,2―a]ピラジン誘導体 |
US6281216B1 (en) * | 1998-02-09 | 2001-08-28 | Duphar International Research B.V. | 2-aminoquinoline derivatives having d4-agonistic activity |
EP0953567A3 (en) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
GT199900060A (es) * | 1998-05-22 | 2000-10-14 | Polimorfos de un monoclorhidrato de pirazina cristalino y sus composiciones farmacèuticas. | |
GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
GB0011013D0 (en) * | 2000-05-09 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
EP1177792A3 (en) * | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
US6670476B2 (en) | 2000-11-29 | 2003-12-30 | Pfizer Inc. | Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine |
GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3388128A (en) * | 1965-09-03 | 1968-06-11 | Allan R. Day | Substituted 1, 4-diazabicyclo [4. 4. 9] decanes |
US4182763A (en) * | 1978-05-22 | 1980-01-08 | Mead Johnson & Company | Buspirone anti-anxiety method |
US4517187A (en) * | 1982-10-18 | 1985-05-14 | Pennwalt Corporation | 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants |
DE3564683D1 (en) * | 1984-08-07 | 1988-10-06 | Cortial | 4-(arylpiperazinylethylaminoethoxy) phenol derivatives, process for their preparation and their therapeutical application |
US4704390A (en) * | 1986-02-13 | 1987-11-03 | Warner-Lambert Company | Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
IT1204803B (it) * | 1986-02-17 | 1989-03-10 | Acraf | Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento |
US4788290A (en) * | 1987-12-11 | 1988-11-29 | American Home Products Corporation | Serotonergic pyrazine derivatives |
SE8803429D0 (sv) * | 1988-09-28 | 1988-09-28 | Pharmacia Ab | Novel pyridyl- and pyrimidyl derivatives |
WO1990008148A1 (en) * | 1989-01-23 | 1990-07-26 | Pfizer Inc. | Bis-aza-bicyclic anxiolytic agents |
ES2072141T3 (es) * | 1991-01-31 | 1995-07-01 | Pfizer | Resolucion de trans-2-(2-pirimidinil)-7-(hidroximetil)octahidro-2h-pirido(1,2a)pirazina. |
US5157034A (en) * | 1991-02-27 | 1992-10-20 | Pfizer Inc. | Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines |
US5185449A (en) * | 1991-02-27 | 1993-02-09 | Pfizer Inc. | Process and intermediate for certain bis-aza-bicyclic anxiolytic agents |
CA2195622C (en) * | 1991-02-27 | 1999-08-17 | Frank J. Urban | Process for preparing trans-piperidine-2,5-dicarboxylates |
EP0607163B1 (en) * | 1991-09-25 | 1996-12-11 | Pfizer Inc. | NEUROLEPTIC 2-SUBSTITUTED PERHYDRO-1-H-PYRIDO[1,2-a]PYRAZINES |
JP2753146B2 (ja) * | 1992-06-16 | 1998-05-18 | ファイザー・インコーポレーテッド | ビス−アザー二環式抗不安薬の製法および中間体 |
ES2133416T3 (es) * | 1992-10-23 | 1999-09-16 | Merck Sharp & Dohme | Ligandos de subtipos de receptores de dopamina. |
JPH08502958A (ja) * | 1992-10-23 | 1996-04-02 | メルク シヤープ エンド ドーム リミテツド | ドーパミンレセプターサブタイプリガンド |
EP0687267B1 (en) * | 1993-03-01 | 1999-09-01 | MERCK SHARP & DOHME LTD. | Pyrrolo-pyridine derivatives as ligands of dopamine receptor |
US5576319A (en) * | 1993-03-01 | 1996-11-19 | Merck, Sharp & Dohme Ltd. | Pyrrolo-pyridine derivatives |
PL310443A1 (en) * | 1993-03-01 | 1995-12-11 | Merck Sharp & Dohme | Derivatives of pyrolo-pyridine |
JPH08508466A (ja) * | 1993-03-05 | 1996-09-10 | メルク シヤープ エンド ドーム リミテツド | ドーパミンd4リガンドとしてのキノロン誘導体 |
GB9416162D0 (en) * | 1994-08-10 | 1994-09-28 | Merck Sharp & Dohme | Therapeutic agents |
-
1995
- 1995-08-24 AU AU31893/95A patent/AU681310B2/en not_active Ceased
- 1995-08-24 PT PT95927915T patent/PT783503E/pt unknown
- 1995-08-24 US US08/809,145 patent/US5852031A/en not_active Expired - Lifetime
- 1995-08-24 ES ES95927915T patent/ES2166830T3/es not_active Expired - Lifetime
- 1995-08-24 UA UA97031431A patent/UA50720C2/uk unknown
- 1995-08-24 SK SK325-97A patent/SK284341B6/sk unknown
- 1995-08-24 HU HU9702037A patent/HUT77354A/hu unknown
- 1995-08-24 WO PCT/IB1995/000689 patent/WO1996010571A1/en active IP Right Grant
- 1995-08-24 RU RU97105362/04A patent/RU2163239C2/ru not_active IP Right Cessation
- 1995-08-24 NZ NZ290936A patent/NZ290936A/en unknown
- 1995-08-24 DE DE69524241T patent/DE69524241T2/de not_active Expired - Lifetime
- 1995-08-24 PL PL95319636A patent/PL180899B1/pl not_active IP Right Cessation
- 1995-08-24 SI SI9520096A patent/SI9520096A/sl not_active IP Right Cessation
- 1995-08-24 EP EP95927915A patent/EP0783503B1/en not_active Expired - Lifetime
- 1995-08-24 CZ CZ97947A patent/CZ285090B6/cs not_active IP Right Cessation
- 1995-08-24 JP JP51155196A patent/JP3287574B2/ja not_active Expired - Lifetime
- 1995-08-24 CN CN95195356A patent/CN1068327C/zh not_active Expired - Fee Related
- 1995-08-24 DK DK95927915T patent/DK0783503T3/da active
- 1995-08-24 AT AT95927915T patent/ATE209648T1/de not_active IP Right Cessation
- 1995-08-24 MX MX9702350A patent/MX9702350A/es unknown
- 1995-08-24 CA CA002200959A patent/CA2200959C/en not_active Expired - Fee Related
- 1995-08-24 KR KR1019970702080A patent/KR100244848B1/ko not_active IP Right Cessation
- 1995-09-18 TW TW084109759A patent/TW406081B/zh not_active IP Right Cessation
- 1995-09-21 IL IL11538495A patent/IL115384A/xx active IP Right Grant
- 1995-09-25 MY MYPI95002850A patent/MY113729A/en unknown
- 1995-09-26 PE PE1995279990A patent/PE47196A1/es not_active Application Discontinuation
- 1995-09-28 CO CO95045095A patent/CO4410335A1/es unknown
- 1995-09-29 ZA ZA958223A patent/ZA958223B/xx unknown
- 1995-09-29 HR HR950507A patent/HRP950507B1/xx not_active IP Right Cessation
- 1995-09-29 YU YU63795A patent/YU63795A/sh unknown
- 1995-09-29 BR BR9504230A patent/BR9504230A/pt not_active IP Right Cessation
- 1995-09-29 TR TR95/01194A patent/TR199501194A2/xx unknown
-
1997
- 1997-03-25 NO NO971416A patent/NO308995B1/no unknown
- 1997-03-27 FI FI971310A patent/FI113655B/fi not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |