SK284341B6 - 2,7-Substituované oktahydro-1H-pyrido[1,2-a]pyrazínové deriváty a farmaceutické prostriedky na ich báze - Google Patents

2,7-Substituované oktahydro-1H-pyrido[1,2-a]pyrazínové deriváty a farmaceutické prostriedky na ich báze Download PDF

Info

Publication number
SK284341B6
SK284341B6 SK325-97A SK32597A SK284341B6 SK 284341 B6 SK284341 B6 SK 284341B6 SK 32597 A SK32597 A SK 32597A SK 284341 B6 SK284341 B6 SK 284341B6
Authority
SK
Slovakia
Prior art keywords
pyrido
octahydro
pyrazine
methyl
substituted
Prior art date
Application number
SK325-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK32597A3 (en
Inventor
Kishor A. Desai
Anton F. J. Fliri
Mark A. Sanner
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of SK32597A3 publication Critical patent/SK32597A3/sk
Publication of SK284341B6 publication Critical patent/SK284341B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK325-97A 1994-09-30 1995-08-24 2,7-Substituované oktahydro-1H-pyrido[1,2-a]pyrazínové deriváty a farmaceutické prostriedky na ich báze SK284341B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31547094A 1994-09-30 1994-09-30
PCT/IB1995/000689 WO1996010571A1 (en) 1994-09-30 1995-08-24 2,7-SUBSTITUTED OCTAHYDRO-1H-PYRIDO[1,2-a]PYRAZINE DERIVATIVES

Publications (2)

Publication Number Publication Date
SK32597A3 SK32597A3 (en) 1998-09-09
SK284341B6 true SK284341B6 (sk) 2005-02-04

Family

ID=23224581

Family Applications (1)

Application Number Title Priority Date Filing Date
SK325-97A SK284341B6 (sk) 1994-09-30 1995-08-24 2,7-Substituované oktahydro-1H-pyrido[1,2-a]pyrazínové deriváty a farmaceutické prostriedky na ich báze

Country Status (34)

Country Link
US (1) US5852031A (es)
EP (1) EP0783503B1 (es)
JP (1) JP3287574B2 (es)
KR (1) KR100244848B1 (es)
CN (1) CN1068327C (es)
AT (1) ATE209648T1 (es)
AU (1) AU681310B2 (es)
BR (1) BR9504230A (es)
CA (1) CA2200959C (es)
CO (1) CO4410335A1 (es)
CZ (1) CZ285090B6 (es)
DE (1) DE69524241T2 (es)
DK (1) DK0783503T3 (es)
ES (1) ES2166830T3 (es)
FI (1) FI113655B (es)
HR (1) HRP950507B1 (es)
HU (1) HUT77354A (es)
IL (1) IL115384A (es)
MX (1) MX9702350A (es)
MY (1) MY113729A (es)
NO (1) NO308995B1 (es)
NZ (1) NZ290936A (es)
PE (1) PE47196A1 (es)
PL (1) PL180899B1 (es)
PT (1) PT783503E (es)
RU (1) RU2163239C2 (es)
SI (1) SI9520096A (es)
SK (1) SK284341B6 (es)
TR (1) TR199501194A2 (es)
TW (1) TW406081B (es)
UA (1) UA50720C2 (es)
WO (1) WO1996010571A1 (es)
YU (1) YU63795A (es)
ZA (1) ZA958223B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) * 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
US6992188B1 (en) 1995-12-08 2006-01-31 Pfizer, Inc. Substituted heterocyclic derivatives
JP3204456B2 (ja) * 1995-12-21 2001-09-04 ファイザー・インコーポレーテッド ２，７―置換オクタヒドロ―ピロロ［１，２―ａ］ピラジン誘導体
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0953567A3 (en) * 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
GT199900060A (es) * 1998-05-22 2000-10-14 Polimorfos de un monoclorhidrato de pirazina cristalino y sus composiciones farmacèuticas.
GB0010757D0 (en) 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
GB0011013D0 (en) * 2000-05-09 2000-06-28 Astrazeneca Ab Chemical compounds
EP1177792A3 (en) * 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
GB0121941D0 (en) 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3564683D1 (en) * 1984-08-07 1988-10-06 Cortial 4-(arylpiperazinylethylaminoethoxy) phenol derivatives, process for their preparation and their therapeutical application
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
IT1204803B (it) * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
ES2072141T3 (es) * 1991-01-31 1995-07-01 Pfizer Resolucion de trans-2-(2-pirimidinil)-7-(hidroximetil)octahidro-2h-pirido(1,2a)pirazina.
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
CA2195622C (en) * 1991-02-27 1999-08-17 Frank J. Urban Process for preparing trans-piperidine-2,5-dicarboxylates
EP0607163B1 (en) * 1991-09-25 1996-12-11 Pfizer Inc. NEUROLEPTIC 2-SUBSTITUTED PERHYDRO-1-H-PYRIDO[1,2-a]PYRAZINES
JP2753146B2 (ja) * 1992-06-16 1998-05-18 ファイザー・インコーポレーテッド ビス−アザー二環式抗不安薬の製法および中間体
ES2133416T3 (es) * 1992-10-23 1999-09-16 Merck Sharp & Dohme Ligandos de subtipos de receptores de dopamina.
JPH08502958A (ja) * 1992-10-23 1996-04-02 メルク シヤープ エンド ドーム リミテツド ドーパミンレセプターサブタイプリガンド
EP0687267B1 (en) * 1993-03-01 1999-09-01 MERCK SHARP & DOHME LTD. Pyrrolo-pyridine derivatives as ligands of dopamine receptor
US5576319A (en) * 1993-03-01 1996-11-19 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
PL310443A1 (en) * 1993-03-01 1995-12-11 Merck Sharp & Dohme Derivatives of pyrolo-pyridine
JPH08508466A (ja) * 1993-03-05 1996-09-10 メルク シヤープ エンド ドーム リミテツド ドーパミンｄ４リガンドとしてのキノロン誘導体
GB9416162D0 (en) * 1994-08-10 1994-09-28 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
DK0783503T3 (da) 2002-02-11
RU2163239C2 (ru) 2001-02-20
MX9702350A (es) 1997-06-28
PL319636A1 (en) 1997-08-18
EP0783503B1 (en) 2001-11-28
NO308995B1 (no) 2000-11-27
DE69524241T2 (de) 2002-06-13
PL180899B1 (pl) 2001-04-30
AU681310B2 (en) 1997-08-21
JP3287574B2 (ja) 2002-06-04
TR199501194A2 (tr) 1996-06-21
HUT77354A (hu) 1998-03-30
NO971416L (no) 1997-05-20
JPH09511527A (ja) 1997-11-18
FI971310A0 (fi) 1997-03-27
SI9520096A (sl) 1998-04-30
US5852031A (en) 1998-12-22
CN1168672A (zh) 1997-12-24
ZA958223B (en) 1997-04-01
YU63795A (sh) 1999-03-04
IL115384A0 (en) 1995-12-31
KR100244848B1 (ko) 2000-03-02
CN1068327C (zh) 2001-07-11
UA50720C2 (uk) 2002-11-15
IL115384A (en) 1999-10-28
NZ290936A (en) 1998-01-26
ATE209648T1 (de) 2001-12-15
BR9504230A (pt) 1996-08-06
NO971416D0 (no) 1997-03-25
CA2200959A1 (en) 1996-04-11
HRP950507B1 (en) 2002-06-30
PE47196A1 (es) 1996-11-11
FI113655B (fi) 2004-05-31
HRP950507A2 (en) 1997-08-31
CZ285090B6 (cs) 1999-05-12
DE69524241D1 (de) 2002-01-10
EP0783503A1 (en) 1997-07-16
CZ94797A3 (cs) 1998-07-15
KR970706282A (ko) 1997-11-03
SK32597A3 (en) 1998-09-09
WO1996010571A1 (en) 1996-04-11
TW406081B (en) 2000-09-21
CA2200959C (en) 2000-05-23
ES2166830T3 (es) 2002-05-01
AU3189395A (en) 1996-04-26
MY113729A (en) 2002-05-31
FI971310A (fi) 1997-03-27
CO4410335A1 (es) 1997-01-09
PT783503E (pt) 2002-03-28

Similar Documents

Publication Publication Date Title
AU2021295423B2 (en) Quinoxaline derivatives as anti-cancer drugs
EP2531498B1 (en) Compounds and compositions as protein kinase inhibitors
CN112752757B (zh) 作为rho-激酶抑制剂的酪氨酸酰胺衍生物
AU775093B2 (en) 2,7-substituted octahydro-1H-pyrido(1,2-a)pyrazine derivatives as ligands for serotonin receptors
SK284341B6 (sk) 2,7-Substituované oktahydro-1H-pyrido[1,2-a]pyrazínové deriváty a farmaceutické prostriedky na ich báze
CN113773335A (zh) 一种作为蛋白质激酶抑制剂的化合物及其制备方法和用途
RU2162470C2 (ru) 2,7-замещенные производные октагидропирроло[1,2-а]пиразина, способ лечения, фармацевтическая композиция, промежуточные соединения
TW202321232A (zh) 小分子sting拮抗劑
MXPA00006403A (es) Derivados 2,7-sustituidos de octahidro-1h-pirido[1,2-a]pirazina