ZA943787B - Aromatic acetylcholinesterase inhibitors - Google Patents
Aromatic acetylcholinesterase inhibitorsInfo
- Publication number
- ZA943787B ZA943787B ZA943787A ZA943787A ZA943787B ZA 943787 B ZA943787 B ZA 943787B ZA 943787 A ZA943787 A ZA 943787A ZA 943787 A ZA943787 A ZA 943787A ZA 943787 B ZA943787 B ZA 943787B
- Authority
- ZA
- South Africa
- Prior art keywords
- aromatic
- acetylcholinesterase inhibitors
- compounds
- acetylcholinesterase
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/361—Preparation of halogenated hydrocarbons by reactions involving a decrease in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93401431A EP0627400A1 (de) | 1993-06-04 | 1993-06-04 | Aromatische Inhibitoren von Acetylcholinesterase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA943787B true ZA943787B (en) | 1995-01-30 |
Family
ID=8214719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA943787A ZA943787B (en) | 1993-06-04 | 1994-05-30 | Aromatic acetylcholinesterase inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5663448A (de) |
| EP (2) | EP0627400A1 (de) |
| JP (1) | JP3735372B2 (de) |
| KR (1) | KR960702820A (de) |
| CN (1) | CN1124953A (de) |
| AT (1) | ATE174895T1 (de) |
| AU (1) | AU676578B2 (de) |
| CA (1) | CA2164303C (de) |
| DE (1) | DE69415522T2 (de) |
| DK (1) | DK0701546T3 (de) |
| ES (1) | ES2127396T3 (de) |
| FI (1) | FI955795A0 (de) |
| HU (1) | HUT73484A (de) |
| IL (1) | IL109863A (de) |
| NO (1) | NO306058B1 (de) |
| NZ (1) | NZ267221A (de) |
| TW (1) | TW385247B (de) |
| WO (1) | WO1994029255A1 (de) |
| ZA (1) | ZA943787B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| US6017887A (en) * | 1995-01-06 | 2000-01-25 | Sibia Neurosciences, Inc. | Peptide, peptide analog and amino acid analog protease inhibitors |
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| US20060142186A1 (en) * | 2004-12-23 | 2006-06-29 | Voyager Pharmaceutical Corporation | Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor antagonists for the treatment of alzheimer's disease |
| US20060194723A1 (en) * | 2005-02-28 | 2006-08-31 | Rabinoff Michael D | Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement |
| EP2089383B1 (de) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| CN109662964A (zh) | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
| ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| CN102791704B (zh) | 2010-03-10 | 2015-11-25 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂 |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| CN102826985B (zh) * | 2012-09-18 | 2015-08-19 | 厦门大学 | 一种1-(3,4,5-三羟基)苯基-1-烷基酮的制备方法 |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| CA2986598C (en) | 2015-05-22 | 2023-09-26 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI783042A (fi) * | 1977-10-07 | 1979-04-08 | Science Union & Cie | Foerfarande foer framstaellning av nya derivat av arylalkankarboxylsyror |
| US4835099A (en) * | 1986-11-20 | 1989-05-30 | Becton, Dickinson And Company | Signal enhancement in immunoassay by modulation of enzymatic catalysis |
| DE3725941A1 (de) * | 1987-08-05 | 1989-02-16 | Hoechst Ag | Ester von arylperfluoralkylcarbinolen, verfahren zur herstellung dieser verbindungen und der zugrundeliegenden arylbisperfluoralkylcarbinole |
| JP2509282B2 (ja) * | 1987-09-24 | 1996-06-19 | 鹿島石油株式会社 | 光学活性なジフルオロアルコ―ル誘導体 |
| US5214069A (en) * | 1988-12-23 | 1993-05-25 | Imperial Chemical Industries Plc | Alcohol and ether derivatives |
| NZ231735A (en) * | 1988-12-23 | 1992-04-28 | Ici Plc | Alcohol/ether derivatives, preparation and pharmaceutical compositions thereof |
| JPH02200646A (ja) * | 1989-01-31 | 1990-08-08 | Nippon Oil & Fats Co Ltd | フルオロアルキル基含有芳香族誘導体及びその製造方法 |
| EP0403713A1 (de) * | 1989-06-22 | 1990-12-27 | Merrell Dow Pharmaceuticals Inc. | Acetylcholinesterase-Inhibitoren |
| DE3927049A1 (de) * | 1989-08-16 | 1991-02-21 | Sandoz Ag | Halogenalkyl-phenyl-ketone und deren hydrate, ihre herstellung und verwendung |
| EP0611769A1 (de) * | 1993-02-16 | 1994-08-24 | Merrell Dow Pharmaceuticals Inc. | Silytierte acetylcholinesterase Inhibitoren |
-
1993
- 1993-06-04 EP EP93401431A patent/EP0627400A1/de not_active Withdrawn
-
1994
- 1994-05-05 JP JP50177495A patent/JP3735372B2/ja not_active Expired - Fee Related
- 1994-05-05 EP EP94917916A patent/EP0701546B1/de not_active Expired - Lifetime
- 1994-05-05 AT AT94917916T patent/ATE174895T1/de not_active IP Right Cessation
- 1994-05-05 AU AU69442/94A patent/AU676578B2/en not_active Ceased
- 1994-05-05 DE DE69415522T patent/DE69415522T2/de not_active Expired - Lifetime
- 1994-05-05 ES ES94917916T patent/ES2127396T3/es not_active Expired - Lifetime
- 1994-05-05 HU HU9503452A patent/HUT73484A/hu unknown
- 1994-05-05 NZ NZ267221A patent/NZ267221A/en unknown
- 1994-05-05 US US08/557,120 patent/US5663448A/en not_active Expired - Lifetime
- 1994-05-05 DK DK94917916T patent/DK0701546T3/da active
- 1994-05-05 KR KR1019950705440A patent/KR960702820A/ko not_active Application Discontinuation
- 1994-05-05 WO PCT/US1994/004957 patent/WO1994029255A1/en active IP Right Grant
- 1994-05-05 CN CN94192338A patent/CN1124953A/zh active Pending
- 1994-05-05 CA CA002164303A patent/CA2164303C/en not_active Expired - Fee Related
- 1994-05-30 ZA ZA943787A patent/ZA943787B/xx unknown
- 1994-05-31 TW TW083104979A patent/TW385247B/zh active
- 1994-06-02 IL IL10986394A patent/IL109863A/en not_active IP Right Cessation
-
1995
- 1995-12-01 NO NO954896A patent/NO306058B1/no not_active IP Right Cessation
- 1995-12-01 FI FI955795A patent/FI955795A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1124953A (zh) | 1996-06-19 |
| KR960702820A (ko) | 1996-05-23 |
| HU9503452D0 (en) | 1996-01-29 |
| EP0701546A1 (de) | 1996-03-20 |
| NO954896D0 (no) | 1995-12-01 |
| NO954896L (no) | 1996-02-02 |
| IL109863A0 (en) | 1994-10-07 |
| AU6944294A (en) | 1995-01-03 |
| HUT73484A (en) | 1996-08-28 |
| FI955795A (fi) | 1995-12-01 |
| TW385247B (en) | 2000-03-21 |
| EP0627400A1 (de) | 1994-12-07 |
| FI955795A0 (fi) | 1995-12-01 |
| CA2164303A1 (en) | 1994-12-22 |
| CA2164303C (en) | 2000-11-28 |
| NO306058B1 (no) | 1999-09-13 |
| DE69415522D1 (de) | 1999-02-04 |
| ATE174895T1 (de) | 1999-01-15 |
| WO1994029255A1 (en) | 1994-12-22 |
| NZ267221A (en) | 1997-11-24 |
| JP3735372B2 (ja) | 2006-01-18 |
| EP0701546B1 (de) | 1998-12-23 |
| DE69415522T2 (de) | 1999-06-02 |
| AU676578B2 (en) | 1997-03-13 |
| US5663448A (en) | 1997-09-02 |
| ES2127396T3 (es) | 1999-04-16 |
| DK0701546T3 (da) | 1999-08-16 |
| IL109863A (en) | 1998-12-27 |
| JPH08511019A (ja) | 1996-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL109863A0 (en) | Aromatic acetylcholinesterase inhibitors | |
| ZA94925B (en) | Silylated acetylcholinesterase inhibitors | |
| GR3024884T3 (en) | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | |
| DE69427869D1 (de) | Botulinumtoxine zur behandlung von hyperhydrosis | |
| EP0611302A4 (de) | Verfahren und zusammensetzungen zur behandlung von allergischen reaktionen. | |
| HUT71550A (en) | Pharmaceutical agents containing quinuclidine, piperidine or azanorbornane derivatives for treatment of emesis | |
| HU9403311D0 (en) | NEW 7BéTA-SUBSTITUTED-4-AZA-5ALPHA-CHOLESTAN-ONES AS 5-ALPHA-REDUCTASE INHIBITORS | |
| EP0674707A4 (de) | Verbindungen und methoden zur behandlung von leukämien. | |
| WO1996031208A3 (de) | Verwendung von substituierten piperidin- oder pyrrolidinverbindungen zur behandlung von sigma-rezeptor modulierten krankheiten | |
| AU6410394A (en) | Method of treating addictive behaviors | |
| GB9317943D0 (en) | Treatment of laminitis | |
| AU2321088A (en) | Method for preventing or treating thrombocytopenia | |
| HU9301187D0 (en) | Method for treating tumours being dependent of gar-transformylase | |
| GB9217355D0 (en) | Treating hides | |
| GB9317989D0 (en) | Treatment of laminitis | |
| EP0581090A3 (de) | Verfahren zum Behandeln von Metallschlämmen. | |
| EP0608702A3 (de) | Verfahren zum Behandeln von Haselnüssen. | |
| ZA934102B (en) | Timber treatment process | |
| EP0654997A4 (de) | Zusammensetzungen von substituierten azaspiranen und verfahren zur behandlung von psoriasis damit. |