ZA9410287B - N-oxides of 4-arylpiperazines and 4-arylpiperidines - Google Patents

N-oxides of 4-arylpiperazines and 4-arylpiperidines

Info

Publication number
ZA9410287B
ZA9410287B ZA9410287A ZA9410287A ZA9410287B ZA 9410287 B ZA9410287 B ZA 9410287B ZA 9410287 A ZA9410287 A ZA 9410287A ZA 9410287 A ZA9410287 A ZA 9410287A ZA 9410287 B ZA9410287 B ZA 9410287B
Authority
ZA
South Africa
Prior art keywords
arylpiperidines
arylpiperazines
oxides
compounds
disclosed
Prior art date
Application number
ZA9410287A
Other languages
English (en)
Inventor
Allen B Reitz
Mark E Mcdonnell
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of ZA9410287B publication Critical patent/ZA9410287B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA9410287A 1993-12-23 1994-12-22 N-oxides of 4-arylpiperazines and 4-arylpiperidines ZA9410287B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17338293A 1993-12-23 1993-12-23

Publications (1)

Publication Number Publication Date
ZA9410287B true ZA9410287B (en) 1996-06-24

Family

ID=22631753

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9410287A ZA9410287B (en) 1993-12-23 1994-12-22 N-oxides of 4-arylpiperazines and 4-arylpiperidines

Country Status (16)

Country Link
EP (1) EP0736009B1 (ru)
JP (1) JPH09507077A (ru)
AT (1) ATE223898T1 (ru)
AU (1) AU687501B2 (ru)
CA (1) CA2179735A1 (ru)
DE (1) DE69431360T2 (ru)
DK (1) DK0736009T3 (ru)
ES (1) ES2183862T3 (ru)
IL (1) IL112099A (ru)
MX (1) MX9500228A (ru)
NZ (1) NZ278261A (ru)
PT (1) PT736009E (ru)
RU (1) RU2123001C1 (ru)
SI (1) SI0736009T1 (ru)
WO (1) WO1995017385A1 (ru)
ZA (1) ZA9410287B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
RU2275359C2 (ru) * 2000-08-11 2006-04-27 Оно Фармасьютикал Ко., Лтд. Производные пиперидина и средство, содержащее производное пиперидина в качестве активного ингредиента
ES2278321T3 (es) 2003-06-12 2007-08-01 Btg International Limited Hidroxilamina ciclica como compuestos psicoactivos.
DK2146961T3 (da) * 2007-04-12 2014-04-28 Ivax Int Gmbh N-oxid- og/eller di-N-oxidderivater af dopaminreceptorstabilisatorer/modulatorer udvisende forbedrede cardiovaskulære bivirkningsprofiler
CA2856749A1 (en) 2011-12-08 2013-06-13 IVAX International GmbH The hydrobromide salt of pridopidine
EP2844346B1 (en) 2012-04-04 2020-01-01 Prilenia Neurotherapeutics Ltd. Pharmaceutical compositions for combination therapy
WO2016106142A1 (en) 2014-12-22 2016-06-30 Teva Pharmaceuticals International Gmbh L-tartrate salt of pridopidine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE914218A1 (en) * 1991-09-11 1993-03-24 Mcneilab Inc Novel 4-arylpiperazines and 4-arylpiperidines
FR2697251B1 (fr) * 1992-10-22 1994-12-02 Synthelabo N-oxydes de dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl] pipéridin-1-yl]éthanol, leur procédé de préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
IL112099A0 (en) 1995-03-15
DE69431360T2 (de) 2003-01-23
AU687501B2 (en) 1998-02-26
ES2183862T3 (es) 2003-04-01
ATE223898T1 (de) 2002-09-15
MX9500228A (es) 1997-02-28
NZ278261A (en) 1998-08-26
EP0736009A1 (en) 1996-10-09
EP0736009B1 (en) 2002-09-11
WO1995017385A1 (en) 1995-06-29
IL112099A (en) 1999-07-14
CA2179735A1 (en) 1995-06-29
RU2123001C1 (ru) 1998-12-10
SI0736009T1 (en) 2003-04-30
DE69431360D1 (de) 2002-10-17
PT736009E (pt) 2003-01-31
JPH09507077A (ja) 1997-07-15
AU1444695A (en) 1995-07-10
DK0736009T3 (da) 2002-10-07

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