DE69431360D1 - N-oxide von 4-arylpiperazinen und 4-arylpiperidinen als antipsychotische medikamente - Google Patents

N-oxide von 4-arylpiperazinen und 4-arylpiperidinen als antipsychotische medikamente

Info

Publication number
DE69431360D1
DE69431360D1 DE69431360T DE69431360T DE69431360D1 DE 69431360 D1 DE69431360 D1 DE 69431360D1 DE 69431360 T DE69431360 T DE 69431360T DE 69431360 T DE69431360 T DE 69431360T DE 69431360 D1 DE69431360 D1 DE 69431360D1
Authority
DE
Germany
Prior art keywords
arylpiperidines
arylpiperazines
oxides
antipsychotic
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431360T
Other languages
English (en)
Other versions
DE69431360T2 (de
Inventor
B Reitz
E Mcdonnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of DE69431360D1 publication Critical patent/DE69431360D1/de
Application granted granted Critical
Publication of DE69431360T2 publication Critical patent/DE69431360T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69431360T 1993-12-23 1994-12-22 N-oxide von 4-arylpiperazinen und 4-arylpiperidinen als antipsychotische medikamente Expired - Fee Related DE69431360T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17338293A 1993-12-23 1993-12-23
PCT/US1994/014850 WO1995017385A1 (en) 1993-12-23 1994-12-22 N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs

Publications (2)

Publication Number Publication Date
DE69431360D1 true DE69431360D1 (de) 2002-10-17
DE69431360T2 DE69431360T2 (de) 2003-01-23

Family

ID=22631753

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431360T Expired - Fee Related DE69431360T2 (de) 1993-12-23 1994-12-22 N-oxide von 4-arylpiperazinen und 4-arylpiperidinen als antipsychotische medikamente

Country Status (16)

Country Link
EP (1) EP0736009B1 (de)
JP (1) JPH09507077A (de)
AT (1) ATE223898T1 (de)
AU (1) AU687501B2 (de)
CA (1) CA2179735A1 (de)
DE (1) DE69431360T2 (de)
DK (1) DK0736009T3 (de)
ES (1) ES2183862T3 (de)
IL (1) IL112099A (de)
MX (1) MX9500228A (de)
NZ (1) NZ278261A (de)
PT (1) PT736009E (de)
RU (1) RU2123001C1 (de)
SI (1) SI0736009T1 (de)
WO (1) WO1995017385A1 (de)
ZA (1) ZA9410287B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
ES2325353T3 (es) * 2000-08-11 2009-09-02 Ono Pharmaceutical Co., Ltd. Derivados de piperidina y medicamentos a base de tales ingredientes activos.
JP4648899B2 (ja) 2003-06-12 2011-03-09 ビーティージー・インターナショナル・リミテッド 神経賦活性化合物としての環式ヒドロキシルアミン
RU2470013C2 (ru) * 2007-04-12 2012-12-20 НСАБ, Филиаль ау НьюроСёрч Свиден АБ, Сверийе N-оксидные и/или ди-n-оксидные производные стабилизаторов/модуляторов рецепторов дофамина, проявляющие улучшенные профили сердечно-сосудистых побочных эффектов
MX347209B (es) 2011-12-08 2017-04-19 Teva Pharmaceuticals Int Gmbh La sal de bromhidrato de pridopidina.
MX2014011971A (es) 2012-04-04 2015-01-16 Ivax Int Gmbh Composiciones farmaceuticas para terapia de combinacion.
US9796673B2 (en) 2014-12-22 2017-10-24 Teva Pharmaceuticals International Gmbh L-tartrate salt of pridopidine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
FR2697251B1 (fr) * 1992-10-22 1994-12-02 Synthelabo N-oxydes de dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl] pipéridin-1-yl]éthanol, leur procédé de préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
DK0736009T3 (da) 2002-10-07
IL112099A0 (en) 1995-03-15
ZA9410287B (en) 1996-06-24
JPH09507077A (ja) 1997-07-15
RU2123001C1 (ru) 1998-12-10
PT736009E (pt) 2003-01-31
AU1444695A (en) 1995-07-10
EP0736009B1 (de) 2002-09-11
DE69431360T2 (de) 2003-01-23
EP0736009A1 (de) 1996-10-09
NZ278261A (en) 1998-08-26
CA2179735A1 (en) 1995-06-29
ES2183862T3 (es) 2003-04-01
AU687501B2 (en) 1998-02-26
MX9500228A (es) 1997-02-28
SI0736009T1 (en) 2003-04-30
WO1995017385A1 (en) 1995-06-29
ATE223898T1 (de) 2002-09-15
IL112099A (en) 1999-07-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN

8339 Ceased/non-payment of the annual fee