ZA939366B - Aryl substituted heterocyclic compounds - Google Patents
Aryl substituted heterocyclic compoundsInfo
- Publication number
- ZA939366B ZA939366B ZA939366A ZA939366A ZA939366B ZA 939366 B ZA939366 B ZA 939366B ZA 939366 A ZA939366 A ZA 939366A ZA 939366 A ZA939366 A ZA 939366A ZA 939366 B ZA939366 B ZA 939366B
- Authority
- ZA
- South Africa
- Prior art keywords
- substituted heterocyclic
- heterocyclic compounds
- aryl substituted
- aryl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK921541A DK154192D0 (da) | 1992-12-23 | 1992-12-23 | Heterocycliske forbindelser |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA939366B true ZA939366B (en) | 1994-08-08 |
Family
ID=8105889
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA939366A ZA939366B (en) | 1992-12-23 | 1993-12-14 | Aryl substituted heterocyclic compounds |
ZA939367A ZA939367B (en) | 1992-12-23 | 1993-12-14 | Antidepressant and antiperkinsonian compounds |
ZA939365A ZA939365B (en) | 1992-12-23 | 1993-12-14 | Alkyl substituted heterocyclic compounds |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA939367A ZA939367B (en) | 1992-12-23 | 1993-12-14 | Antidepressant and antiperkinsonian compounds |
ZA939365A ZA939365B (en) | 1992-12-23 | 1993-12-14 | Alkyl substituted heterocyclic compounds |
Country Status (4)
Country | Link |
---|---|
US (3) | US5369113A (ko) |
KR (3) | KR100300799B1 (ko) |
DK (1) | DK154192D0 (ko) |
ZA (3) | ZA939366B (ko) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6706880B2 (en) * | 1990-08-09 | 2004-03-16 | Research Triangle Institute | Cocaine receptor binding ligands |
US6329520B1 (en) * | 1990-08-09 | 2001-12-11 | Research Triangle Institute | Cocaine receptor binding ligands |
US7189737B2 (en) * | 1991-08-09 | 2007-03-13 | Research Triangle Institute | Cocaine receptor binding ligands |
US5736123A (en) * | 1990-08-09 | 1998-04-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US6531483B1 (en) * | 1990-08-09 | 2003-03-11 | Research Triangle Institute | Cocaine receptor binding ligands |
US7011813B2 (en) * | 1990-08-09 | 2006-03-14 | Research Triangle Institute | Cocaine receptor binding ligands |
US5935953A (en) * | 1990-08-09 | 1999-08-10 | Research Triangle Institute | Methods for controlling invertebrate pests using cocaine receptor binding ligands |
US5698179A (en) * | 1992-02-25 | 1997-12-16 | Neuro Imaging Technologies, Llc | Iodinated neuroprobe for mapping monoamine reuptake sites |
US5750089A (en) * | 1996-01-11 | 1998-05-12 | Neuro Imaging Technologies, Llc | Halogenated neuroprobe for mapping monoamine reuptake sites |
US5760055A (en) * | 1992-03-13 | 1998-06-02 | Wake Forest University | Biologically active tropane derivatives |
US6632456B1 (en) * | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
EP0831941B1 (en) * | 1995-06-06 | 2012-04-04 | GE Healthcare Limited | Iodinated neuroprobes for mapping monoamine reuptake sites |
IL123583A (en) * | 1995-10-13 | 2003-07-31 | Neurosearch As | 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them |
US5948933A (en) * | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
AU778629B2 (en) * | 1996-08-22 | 2004-12-16 | Research Triangle Institute | Cocaine receptor binding ligands |
WO1998024788A1 (en) * | 1996-12-02 | 1998-06-11 | Georgetown University | Tropane derivatives and method for their synthesis |
US5834484A (en) * | 1997-03-12 | 1998-11-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Cocaine analogs |
US6013242A (en) * | 1998-01-13 | 2000-01-11 | Wake Forest University | Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression |
JP4907818B2 (ja) * | 1999-11-03 | 2012-04-04 | エーエムアール テクノロジー インコーポレイテッド | アリールおよびヘテロアリール置換テトラヒドロイソキノリン、ならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを阻止するためのそれらの使用 |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
ATE407124T1 (de) * | 2000-01-11 | 2008-09-15 | Molecular Insight Pharm Inc | Polypharmacophore verbindungen |
US6479509B1 (en) | 2000-05-22 | 2002-11-12 | Research Triangle Institute | Method of promoting smoking cessation |
CN100430401C (zh) * | 2000-07-11 | 2008-11-05 | Amr科技公司 | 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途 |
US20040030131A1 (en) * | 2000-10-04 | 2004-02-12 | Martine Keenan | Pharmaceutical compounds |
WO2002064128A1 (en) * | 2001-02-15 | 2002-08-22 | Neurosearch A/S | Treatment of diseases characterized by excessive or insufficient cell death |
JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
WO2003014114A2 (en) * | 2001-08-08 | 2003-02-20 | Neurosearch A/S | Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
ATE345135T1 (de) * | 2001-11-30 | 2006-12-15 | Neurosearch As | Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen |
EP1483237A4 (en) * | 2002-03-28 | 2006-07-05 | Harvard College | TROPANE COMPOUNDS |
NZ547152A (en) * | 2003-10-16 | 2009-12-24 | Neurosearch As | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
US20050278472A1 (en) * | 2004-06-14 | 2005-12-15 | Gierke Justin T | USB extender |
WO2006020049A2 (en) | 2004-07-15 | 2006-02-23 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
US20060111394A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
KR101589551B1 (ko) * | 2005-07-15 | 2016-02-02 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
KR20120034644A (ko) * | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
EP2429293B1 (en) | 2009-05-12 | 2014-10-29 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
EP2606049A4 (en) | 2010-08-17 | 2014-01-08 | Albany Molecular Res Inc | 2,5-METHANO- AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USES THEREOF FOR BLOCKING NOREPINEPHRINE, DOPAMINE, AND SEROTONIN REUPTAKE |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US813404A (en) * | 1905-07-19 | 1906-02-27 | Joseph W Mccord | Process for removing rough and irregular foreign seeds from clover and other smooth seeds. |
US3813404A (en) * | 1972-11-15 | 1974-05-28 | Sterling Drug Inc | Tropane-2-carboxylates and derivatives |
DK0644775T3 (da) * | 1991-11-15 | 2000-03-06 | Nat Inst Health | Kokainreceptorbindende ligander |
-
1992
- 1992-12-23 DK DK921541A patent/DK154192D0/da not_active Application Discontinuation
-
1993
- 1993-07-16 US US08/093,183 patent/US5369113A/en not_active Expired - Lifetime
- 1993-07-16 US US08/093,181 patent/US5444070A/en not_active Expired - Lifetime
- 1993-07-16 US US08/093,182 patent/US5374636A/en not_active Expired - Lifetime
- 1993-12-14 ZA ZA939366A patent/ZA939366B/xx unknown
- 1993-12-14 ZA ZA939367A patent/ZA939367B/xx unknown
- 1993-12-14 ZA ZA939365A patent/ZA939365B/xx unknown
- 1993-12-23 KR KR1019930029243A patent/KR100300799B1/ko not_active IP Right Cessation
- 1993-12-23 KR KR1019930029245A patent/KR100310663B1/ko not_active IP Right Cessation
- 1993-12-23 KR KR1019930029244A patent/KR100344328B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK154192D0 (da) | 1992-12-23 |
ZA939367B (en) | 1994-08-08 |
ZA939365B (en) | 1994-08-08 |
KR100310663B1 (ko) | 2002-06-20 |
KR100300799B1 (ko) | 2001-11-22 |
US5374636A (en) | 1994-12-20 |
KR940013555A (ko) | 1994-07-15 |
US5369113A (en) | 1994-11-29 |
KR940013507A (ko) | 1994-07-15 |
KR100344328B1 (ko) | 2002-11-29 |
KR940013508A (ko) | 1994-07-15 |
US5444070A (en) | 1995-08-22 |
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