ZA937315B - Anti-arrhythmic analgesically acting phthalazinone derivatives that brea through multi-drug resistance - Google Patents
Anti-arrhythmic analgesically acting phthalazinone derivatives that brea through multi-drug resistanceInfo
- Publication number
- ZA937315B ZA937315B ZA937315A ZA937315A ZA937315B ZA 937315 B ZA937315 B ZA 937315B ZA 937315 A ZA937315 A ZA 937315A ZA 937315 A ZA937315 A ZA 937315A ZA 937315 B ZA937315 B ZA 937315B
- Authority
- ZA
- South Africa
- Prior art keywords
- analgesically
- brea
- arrhythmic
- acting
- drug resistance
- Prior art date
Links
- 230000036457 multidrug resistance Effects 0.000 title abstract 2
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical class C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title abstract 2
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- 239000003416 antiarrhythmic agent Substances 0.000 title 1
- HQFSNUYUXXPVKL-UHFFFAOYSA-N 4-[(4-fluorophenyl)methyl]-2-[1-(2-phenylethyl)azepan-4-yl]phthalazin-1-one Chemical compound C1=CC(F)=CC=C1CC(C1=CC=CC=C1C1=O)=NN1C1CCN(CCC=2C=CC=CC=2)CCC1 HQFSNUYUXXPVKL-UHFFFAOYSA-N 0.000 abstract 1
- MBUVEWMHONZEQD-UHFFFAOYSA-N Azeptin Chemical compound C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 MBUVEWMHONZEQD-UHFFFAOYSA-N 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 229960004574 azelastine Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229950006000 flezelastine Drugs 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4233113 | 1992-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA937315B true ZA937315B (en) | 1994-04-22 |
Family
ID=6469448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA937315A ZA937315B (en) | 1992-10-02 | 1993-10-01 | Anti-arrhythmic analgesically acting phthalazinone derivatives that brea through multi-drug resistance |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5556856A (cs) |
| EP (1) | EP0590551B1 (cs) |
| JP (1) | JP3623975B2 (cs) |
| CN (1) | CN1088435A (cs) |
| AT (1) | ATE144708T1 (cs) |
| AU (1) | AU666773B2 (cs) |
| CA (1) | CA2107548A1 (cs) |
| CZ (1) | CZ199593A3 (cs) |
| DE (1) | DE59304351D1 (cs) |
| DK (1) | DK0590551T3 (cs) |
| ES (1) | ES2096168T3 (cs) |
| GR (1) | GR3022070T3 (cs) |
| HU (1) | HUT65353A (cs) |
| MX (1) | MX9306120A (cs) |
| RU (1) | RU2106143C1 (cs) |
| SK (1) | SK104493A3 (cs) |
| UA (1) | UA26953C2 (cs) |
| ZA (1) | ZA937315B (cs) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162616A (en) * | 1997-04-16 | 2000-12-19 | Millennium Pharmaceuticals, Inc. | Multidrug resistance-associated polypeptide |
| US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| JP2005508990A (ja) * | 2001-11-07 | 2005-04-07 | ファルマシア・コーポレーション | 真核細胞におけるポリアミドの取込みおよび核蓄積を促進する方法 |
| WO2003093261A1 (en) | 2002-04-30 | 2003-11-13 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7294701B2 (en) * | 2003-04-02 | 2007-11-13 | Technion Research & Development Foundation Ltd. | Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| GB0428111D0 (en) * | 2004-12-22 | 2005-01-26 | Kudos Pharm Ltd | Pthalazinone derivatives |
| GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| EA200801996A1 (ru) * | 2006-04-20 | 2009-04-28 | Глаксо Груп Лимитед | 2-замещенные производные 4-бензилфталазинонов в качестве гистаминовых h1- и h3-антагонистов |
| EP2041110A1 (en) * | 2006-06-15 | 2009-04-01 | Kudos Pharmaceuticals Limited | 2 -oxyheteroarylamide derivatives as parp inhibitors |
| US20090209520A1 (en) * | 2006-06-15 | 2009-08-20 | Kudos Pharmaceuticals Limited | 2 -oxybenzamide derivatives as parp inhibitors |
| CN101500997A (zh) * | 2006-06-15 | 2009-08-05 | 库多斯药物有限公司 | Parp抑制剂 |
| TWI404716B (zh) | 2006-10-17 | 2013-08-11 | Kudos Pharm Ltd | 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物 |
| US20100184770A1 (en) * | 2006-12-20 | 2010-07-22 | Glaxo Group Limited | Compounds |
| US20080280910A1 (en) * | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
| TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| WO2009034326A1 (en) | 2007-09-14 | 2009-03-19 | Astrazeneca Ab | Phthalazinone derivatives |
| EP2215082B1 (en) * | 2007-10-11 | 2011-09-21 | Glaxo Group Limited | Phthalazine and pyrido[3,4-d]pyridazine compounds as h1 receptor antagonists |
| RU2487868C2 (ru) | 2007-10-17 | 2013-07-20 | Кудос Фармасеутикалс Лимитед | 4-[3-(4-циклопропанкарбонил-пиперазин-1-карбонил)-4-фтор-бензил]-2н-фталазин-1-он |
| UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
| CA2737400C (en) | 2008-10-07 | 2016-11-22 | Astrazeneca Uk Limited | Pharmaceutical formulation 514 |
| US20110015393A1 (en) * | 2009-07-15 | 2011-01-20 | Astrazeneca Ab | Phthalazinone compound |
| US9790215B2 (en) | 2013-03-13 | 2017-10-17 | Flatley Discovery Lab, Llc | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE60598T1 (de) * | 1985-11-11 | 1991-02-15 | Asta Pharma Ag | 4-benzyl-1-(2h)-phthalazinon-derivate. |
| JPH0667844B2 (ja) * | 1987-03-06 | 1994-08-31 | エーザイ株式会社 | 虚血性心疾患の治療・予防剤 |
| US5110814A (en) * | 1989-01-11 | 1992-05-05 | Asta Pharma Ag | Azelastine and its salts used to combat psoriasis |
-
1993
- 1993-09-24 CZ CZ931995A patent/CZ199593A3/cs unknown
- 1993-09-25 AT AT93115512T patent/ATE144708T1/de not_active IP Right Cessation
- 1993-09-25 ES ES93115512T patent/ES2096168T3/es not_active Expired - Lifetime
- 1993-09-25 EP EP93115512A patent/EP0590551B1/de not_active Expired - Lifetime
- 1993-09-25 DE DE59304351T patent/DE59304351D1/de not_active Expired - Lifetime
- 1993-09-25 DK DK93115512.1T patent/DK0590551T3/da active
- 1993-09-29 CN CN93118175A patent/CN1088435A/zh active Pending
- 1993-09-30 SK SK1044-93A patent/SK104493A3/sk unknown
- 1993-09-30 UA UA93002239A patent/UA26953C2/uk unknown
- 1993-10-01 MX MX9306120A patent/MX9306120A/es unknown
- 1993-10-01 ZA ZA937315A patent/ZA937315B/xx unknown
- 1993-10-01 JP JP24683493A patent/JP3623975B2/ja not_active Expired - Fee Related
- 1993-10-01 CA CA002107548A patent/CA2107548A1/en not_active Abandoned
- 1993-10-01 HU HU9302784A patent/HUT65353A/hu unknown
- 1993-10-01 RU RU93056139A patent/RU2106143C1/ru active
- 1993-10-01 AU AU48769/93A patent/AU666773B2/en not_active Ceased
-
1995
- 1995-04-04 US US08/416,467 patent/US5556856A/en not_active Expired - Fee Related
-
1996
- 1996-12-18 GR GR960403515T patent/GR3022070T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1088435A (zh) | 1994-06-29 |
| DK0590551T3 (da) | 1997-04-21 |
| CZ199593A3 (en) | 1994-04-13 |
| GR3022070T3 (en) | 1997-03-31 |
| US5556856A (en) | 1996-09-17 |
| AU4876993A (en) | 1994-04-14 |
| JPH06312928A (ja) | 1994-11-08 |
| ATE144708T1 (de) | 1996-11-15 |
| HUT65353A (en) | 1994-05-02 |
| HU9302784D0 (en) | 1993-12-28 |
| DE59304351D1 (de) | 1996-12-05 |
| EP0590551A2 (de) | 1994-04-06 |
| UA26953C2 (uk) | 1999-12-29 |
| CA2107548A1 (en) | 1994-04-03 |
| AU666773B2 (en) | 1996-02-22 |
| EP0590551B1 (de) | 1996-10-30 |
| MX9306120A (es) | 1994-04-29 |
| EP0590551A3 (cs) | 1994-08-31 |
| JP3623975B2 (ja) | 2005-02-23 |
| ES2096168T3 (es) | 1997-03-01 |
| RU2106143C1 (ru) | 1998-03-10 |
| SK104493A3 (en) | 1994-08-10 |
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