ZA932568B - Production of recombinant human lactoferrin - Google Patents

Production of recombinant human lactoferrin

Info

Publication number
ZA932568B
ZA932568B ZA932568A ZA932568A ZA932568B ZA 932568 B ZA932568 B ZA 932568B ZA 932568 A ZA932568 A ZA 932568A ZA 932568 A ZA932568 A ZA 932568A ZA 932568 B ZA932568 B ZA 932568B
Authority
ZA
South Africa
Prior art keywords
human lactoferrin
production
recombinant human
lactoferrin protein
methods
Prior art date
Application number
ZA932568A
Other languages
English (en)
Inventor
Orla Maoiliosa Conneely
Denis Robert Headon
Bert William O'malley
Gregory Stuart May
Original Assignee
Baylor College Midecine A Non
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Midecine A Non filed Critical Baylor College Midecine A Non
Publication of ZA932568B publication Critical patent/ZA932568B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA932568A 1992-04-24 1993-04-13 Production of recombinant human lactoferrin ZA932568B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87330492A 1992-04-24 1992-04-24

Publications (1)

Publication Number Publication Date
ZA932568B true ZA932568B (en) 1993-11-12

Family

ID=25361366

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA932568A ZA932568B (en) 1992-04-24 1993-04-13 Production of recombinant human lactoferrin

Country Status (19)

Country Link
US (1) US5571896A (fr)
EP (1) EP0644899B1 (fr)
JP (1) JP2824332B2 (fr)
KR (2) KR0184693B1 (fr)
CN (2) CN1161382C (fr)
AT (1) ATE177473T1 (fr)
AU (1) AU681583B2 (fr)
BR (1) BR9306289A (fr)
CA (1) CA2134094C (fr)
DE (1) DE69323879T2 (fr)
DK (1) DK0644899T3 (fr)
ES (1) ES2132232T3 (fr)
GR (1) GR3029942T3 (fr)
HK (1) HK1027360A1 (fr)
IL (1) IL105400A (fr)
NZ (1) NZ252844A (fr)
SG (1) SG47605A1 (fr)
WO (1) WO1993022348A1 (fr)
ZA (1) ZA932568B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US6066469A (en) 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
JP3529423B2 (ja) * 1994-04-01 2004-05-24 森永乳業株式会社 抗菌性ペプチドの製造方法
FR2735983B1 (fr) 1995-06-29 1997-12-05 Centre Nat Rech Scient Peptide permettant de modifier l'activite du systeme immunitaire humain ou animal
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
AU6307698A (en) 1997-02-03 1998-08-25 Pharming Bv Useful properties of human lactoferrin and variants thereof
WO2000004132A1 (fr) * 1998-07-15 2000-01-27 Samyang Genex Corporation Production massive de lactoferrine a partir de levure et micro-organisme utile ainsi obtenu
US6423509B1 (en) 1998-07-15 2002-07-23 Samyang Genex Corporation Pichia pastoris strain for producing lactoferrin and methods of use
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
AU7042000A (en) * 1999-10-19 2001-05-14 Easy Bio System, Inc. Recombinant yeast strain for expressing human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin and process for preparation recombinant human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin using the same
US7417178B2 (en) * 2000-05-02 2008-08-26 Ventria Bioscience Expression of human milk proteins in transgenic plants
US20080050503A1 (en) * 2000-05-02 2008-02-28 Ning Huang Expression of human milk proteins in transgenic plants
US7138150B2 (en) * 2000-05-02 2006-11-21 Ventria Bioscience Method of making an anti-infective composition for treating oral infections
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
MXPA04001804A (es) * 2001-08-30 2005-03-07 Biorexis Pharmaceutical Corp Proteinas de fusion de transferrina modificada.
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US20070031440A1 (en) * 2001-08-30 2007-02-08 Prior Christopher P Modified transferin-antibody fusion proteins
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
AU2002357934A1 (en) * 2001-12-28 2003-07-24 Campina B.V. Humanized lactoferrin and uses thereof
CA2484656A1 (fr) 2002-05-10 2003-12-04 Agennix Incorporated Lactoferrine dans le traitement de tumeurs malignes et autres maladies hyperproliferatives
US7238661B2 (en) * 2002-05-24 2007-07-03 Agennix, Inc. Oral lactoferrin in the treatment of respiratory disorders
US20060105387A1 (en) * 2002-08-30 2006-05-18 Prior Christopher P Transferrin fusion proteins libraries
US20060130158A1 (en) * 2002-08-30 2006-06-15 Turner Andrew J Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains
DK1545587T3 (da) * 2002-09-16 2011-05-09 Agennix Inc Lactoferrinsammensætninger og fremgangsmåder til behandling af diabetiske sår
CA2508912A1 (fr) * 2002-12-06 2004-06-24 Agennix Incorporated Lactoferrine orale pour le traitement des sepsies
US7592306B2 (en) * 2002-12-10 2009-09-22 Agennix, Inc. Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
US20070060512A1 (en) * 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
KR100468596B1 (ko) * 2003-04-04 2005-01-27 (주) 디지탈바이오텍 메탄올자화효모인 피치아 패스토리스를 이용하여 인간락토페린을 생산하는 방법, 이 방법에 의해 제조된 인간락토페린 및 피치아 패스토리스 균주
US7379700B2 (en) * 2003-05-06 2008-05-27 Canon Kabushiki Kaisha Image reading apparatus with rotatable internal and external guides
JP2007524654A (ja) * 2003-06-06 2007-08-30 エイジェニックス インコーポレイテッド 癌ワクチン中のアジュバントとしてのラクトフェリン
US20040259770A1 (en) * 2003-06-19 2004-12-23 Rush University Medical Center Method for determining leukocyte activation
WO2005018542A2 (fr) * 2003-07-10 2005-03-03 Agennix Incorporated Utilisation de lactoferrine dans une prophylaxie dirigee contre une infection et/ou contre une inflammation, chez des patients immunosupprimes
JP2007512001A (ja) * 2003-08-28 2007-05-17 バイオレクシス ファーマシューティカル コーポレイション Ｅｐｏミメティックペプチドおよび融合タンパク質
US20060205037A1 (en) * 2003-08-28 2006-09-14 Homayoun Sadeghi Modified transferrin fusion proteins
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
WO2005085287A1 (fr) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Traitements pour la reduction de contaminants dans des preparations de lactoferrines et compositions contenant des lactoferrines
US7183381B2 (en) 2004-10-26 2007-02-27 Agennix, Inc. Composition of lactoferrin related peptides and uses thereof
DK2330200T3 (en) 2004-12-23 2017-07-24 Albumedix As GENE EXPRESSION TECHNIQUE
EP2049135A4 (fr) 2006-06-22 2009-12-30 Agennix Inc Lactoferrine en tant qu'agent radioprotecteur
KR101193722B1 (ko) * 2006-07-24 2013-01-11 바이오렉시스 파마슈티칼 코포레이션 엑센딘 융합 단백질
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
EP2173770B1 (fr) 2007-07-10 2015-05-27 Glanbia Nutritionals (Ireland) Limited Procédé d'élimination d'endotoxines de protéines
US20130225477A1 (en) 2010-02-25 2013-08-29 Agennix Ag Oral Lactoferrin in the Treatment of Severe Sepsis
EP2851421B1 (fr) 2012-07-03 2018-11-28 Kao Corporation Microorganisme utile, et procédé de production d'une substance souhaitée
KR20210091206A (ko) * 2018-11-06 2021-07-21 아르헬 프로젝티랜제 인 인제나이어링 디.오.오. 우유, 초유 및 산 또는 스위트 유청으로부터 고도로 정제된 락토페린 및 락토퍼옥시다제를 제조하는 방법
KR200494603Y1 (ko) 2019-12-09 2021-11-12 한국청소년활동진흥원 타워형 구조를 이루는 기술 융합형 조립 교구

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
DK122686D0 (da) * 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
AU619458B2 (en) * 1987-01-30 1992-01-30 Board Of Trustees Of The Leland Stanford Junior University Lymphocyte inhibition by hla peptides
EP0383779B2 (fr) * 1987-09-04 2000-05-31 Novo Nordisk A/S PROCEDE DE PRODUCTION DE PROTEINES DANS $i(ASPERGILLUS) ET PROMOTEURS DESTINES A EXPRIMER CE CHAMPIGNON
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5155037A (en) * 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
AU7453391A (en) * 1990-03-08 1991-10-10 Ferrodynamics, Inc. Genetically engineered human lactoferrin
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤

Also Published As

Publication number Publication date
EP0644899B1 (fr) 1999-03-10
GR3029942T3 (en) 1999-07-30
CN1161382C (zh) 2004-08-11
CA2134094C (fr) 2004-01-06
AU681583B2 (en) 1997-09-04
SG47605A1 (en) 1998-04-17
EP0644899A1 (fr) 1995-03-29
DE69323879D1 (de) 1999-04-15
KR100221404B1 (en) 1999-10-01
KR950701348A (ko) 1995-03-23
BR9306289A (pt) 1998-06-30
JP2824332B2 (ja) 1998-11-11
DK0644899T3 (da) 1999-09-27
ES2132232T3 (es) 1999-08-16
NZ252844A (en) 1996-05-28
AU4289293A (en) 1993-11-29
IL105400A (en) 2003-03-12
CN1079780A (zh) 1993-12-22
HK1027360A1 (en) 2001-01-12
CN1250055A (zh) 2000-04-12
JPH08504561A (ja) 1996-05-21
DE69323879T2 (de) 1999-11-04
CA2134094A1 (fr) 1993-11-11
KR0184693B1 (ko) 1999-04-01
CN1047204C (zh) 1999-12-08
ATE177473T1 (de) 1999-03-15
IL105400A0 (en) 1993-08-18
EP0644899A4 (fr) 1996-06-26
US5571896A (en) 1996-11-05
WO1993022348A1 (fr) 1993-11-11

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