ZA932228B - 1,2-(Arylsulphonylamino)-1-oxoethyl piperidine derivatives, their preparation and their therapeutic application - Google Patents

1,2-(Arylsulphonylamino)-1-oxoethyl piperidine derivatives, their preparation and their therapeutic application

Info

Publication number
ZA932228B
ZA932228B ZA932228A ZA932228A ZA932228B ZA 932228 B ZA932228 B ZA 932228B ZA 932228 A ZA932228 A ZA 932228A ZA 932228 A ZA932228 A ZA 932228A ZA 932228 B ZA932228 B ZA 932228B
Authority
ZA
South Africa
Prior art keywords
group
hydrogen atom
alkyl group
alkyl
arylsulphonylamino
Prior art date
Application number
ZA932228A
Other languages
English (en)
Inventor
Gilbert Lassalle
Daniel Galtier
Frederic Galli
Thomas Purcell
Paul Howard Williams
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA932228B publication Critical patent/ZA932228B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA932228A 1992-03-30 1993-03-29 1,2-(Arylsulphonylamino)-1-oxoethyl piperidine derivatives, their preparation and their therapeutic application ZA932228B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203828A FR2689130B1 (fr) 1992-03-30 1992-03-30 Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ZA932228B true ZA932228B (en) 1993-10-28

Family

ID=9428242

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA932228A ZA932228B (en) 1992-03-30 1993-03-29 1,2-(Arylsulphonylamino)-1-oxoethyl piperidine derivatives, their preparation and their therapeutic application

Country Status (21)

Country Link
US (1) US5453430A (ja)
EP (2) EP0579277A1 (ja)
JP (2) JP2550276B2 (ja)
KR (1) KR930019664A (ja)
CN (1) CN1076928A (ja)
AT (1) ATE161839T1 (ja)
AU (1) AU655876B2 (ja)
CA (1) CA2092867A1 (ja)
CZ (1) CZ52893A3 (ja)
DE (1) DE69316068T2 (ja)
FI (1) FI931413A (ja)
FR (1) FR2689130B1 (ja)
HU (1) HUT64758A (ja)
IL (1) IL105028A0 (ja)
MX (1) MX9301783A (ja)
NO (2) NO302572B1 (ja)
NZ (1) NZ247277A (ja)
PL (1) PL298299A1 (ja)
SK (1) SK26393A3 (ja)
TW (1) TW234717B (ja)
ZA (1) ZA932228B (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (fr) 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
CA2122397A1 (en) * 1993-05-03 1994-11-04 Spencer D. Kimball Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors
FR2710066B1 (fr) * 1993-09-14 1995-10-20 Synthelabo Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2710061B1 (fr) * 1993-09-14 1995-12-29 Synthelabo Acides et chlorures d'acides 1,2,3, 4-tétrahydroquinoléine-8-sulfoniques, et leur utilisation comme intermédiaires de synthèse.
FR2718444B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de (3-méthyl-1, 2, 3, 4-tétrahydroquinoléin-8-yl)sulfonyle, leur préparation et leur application en thérapeutique.
FR2718442B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de 5-(1H-imidazol-4-yl)-1-oxopentylpipéridine, leur préparation et leur application en thérapeutique.
FR2718443B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de 1-[2-[[(3-méthyl-1, 2, 3, 4-tétrahydroquinoléin-8-yl)sulfonyl] amino]-1-oxo-5-(1H-imidazol-4-yl)pentyl]pipéridine, leur préparation et leur application en thérapeutique.
FR2718439B3 (fr) * 1994-04-12 1996-02-09 Synthelabo Dérivés de l'acide pipécolique, leur préparation et leur utilisation comme intermédiaires de synthèse.
DE4424828A1 (de) * 1994-07-14 1996-01-18 Thomae Gmbh Dr K Neue substituierte Arylsulfonamide, ihre Herstellung und ihre Verwendung als Arzneimittel
FR2727413B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Derives de 5-(1h-imidazol-4-yl)-1-oxo-2-(phenylsulfonamino)- pentylpiperidine, leur preparation et leur application en therapeutique
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
GB9505538D0 (en) * 1995-03-18 1995-05-03 Ciba Geigy Ag New compounds
US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
FR2747677B1 (fr) * 1996-04-22 1998-06-05 Synthelabo Derives de propargylglycine, leur preparation et leur utilisation comme intermediaires de synthese
IL125918A0 (en) * 1996-04-22 1999-04-11 Synthelabo Propargylgycine derivatives preparation and utilisation thereof as synthesis intermediates
FR2747676B1 (fr) * 1996-04-22 1998-06-05 Synthelabo Derives de [1-oxo-2-(sulfonylamino)ethyl] piperidine, leur preparation et leur application en therapeutique
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
FR2756285B1 (fr) * 1996-11-22 1998-12-18 Synthelabo Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique
US5773089A (en) * 1996-12-18 1998-06-30 E. I. Du Pont De Nemours And Company Process for treating aramid surfaces to be plated
FR2765220B1 (fr) * 1997-06-25 1999-07-30 Synthelabo Derives de 1-oxo-2-(phenylsulfonyl)aminopentyle, leur preparation et leur application en therapeutique
FR2771094B1 (fr) * 1997-11-19 2000-02-04 Synthelabo Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique
WO2006123020A1 (en) * 2005-05-18 2006-11-23 Juvantia Pharma Ltd Oy Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4
CA2747770C (en) * 2008-12-22 2017-10-17 Kouji Yokoyama Melanin production inhibitor
CN101794567B (zh) * 2010-02-10 2014-01-01 中兴通讯股份有限公司 图片加载的方法及终端
CN104098647B (zh) * 2014-06-24 2017-12-08 安徽省逸欣铭医药科技有限公司 阿加曲班类似物及其制备方法和医药用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
EP0008596A1 (fr) * 1978-09-04 1980-03-19 DEVINTER Europe S.A. Société anonyme dite: Procédé de préparation de dérivés du type 4-hydroxyméthyl imidazole à partir d'esters d'acides 4-imidazole carboxyliques correspondants
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
DK134687A (da) 1986-03-17 1987-09-18 Glaxo Group Ltd Indolderivater
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
FR2689130B1 (fr) 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
SK26393A3 (en) 1993-12-08
FR2689130A1 (fr) 1993-10-01
NO931166L (no) 1993-10-01
TW234717B (en) 1994-11-21
HUT64758A (en) 1994-02-28
EP0565396B1 (fr) 1998-01-07
JP2550276B2 (ja) 1996-11-06
NO975664L (no) 1993-10-01
NZ247277A (en) 1995-07-26
DE69316068T2 (de) 1998-08-13
DE69316068D1 (de) 1998-02-12
NO302572B1 (no) 1998-03-23
NO931166D0 (no) 1993-03-29
MX9301783A (es) 1994-02-28
JPH0798807B2 (ja) 1995-10-25
EP0565396A1 (fr) 1993-10-13
AU3556093A (en) 1993-10-07
JPH06199807A (ja) 1994-07-19
IL105028A0 (en) 1993-07-08
CN1076928A (zh) 1993-10-06
KR930019664A (ko) 1993-10-18
FI931413A0 (fi) 1993-03-29
HU9300915D0 (en) 1993-06-28
FI931413A (fi) 1993-10-01
PL298299A1 (en) 1993-10-18
CZ52893A3 (en) 1994-02-16
AU655876B2 (en) 1995-01-12
EP0579277A1 (fr) 1994-01-19
US5453430A (en) 1995-09-26
FR2689130B1 (fr) 1994-05-27
JPH06157514A (ja) 1994-06-03
ATE161839T1 (de) 1998-01-15
CA2092867A1 (fr) 1993-10-01
NO975664D0 (no) 1997-12-05

Similar Documents

Publication Publication Date Title
ZA932228B (en) 1,2-(Arylsulphonylamino)-1-oxoethyl piperidine derivatives, their preparation and their therapeutic application
PL292101A1 (en) Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
MX9201507A (es) Derivados de piperidina, su preparacion y su aplicacion en terapeutica.
IT1226100B (it) Derivati benzimidazolici farmacologicamente attivi.
IE43847L (en) N-substituted phenylpiperidine derivatives.
NZ242154A (en) N-nitrooxyalkyl-2-oxothiazolidine and -oxazoline carboxamide derivatives; their preparation and pharmaceutical compositions
ES8801922A1 (es) Procedimiento para la fabricacion de un ester acido 1 beta-(2-(2-amino-4-tiazolil)alquenoilamino)-3-cefem-4-carboxilico.
AU7624494A (en) Imidazolidinone derivative, acid-addition salt thereof, and remedy for senile dementia
ES8304142A1 (es) "procedimiento para preparar productos derivados del acido 2-amino-tiazolil-2-oxiimino-acetamido-biciclo-octeno-carboxilico".
DK0411631T3 (da) Antipsykotiske forbindelser
DE69329618T2 (de) 3-oxo-1,4-benzothiazin-derivate
IL98979A0 (en) Lowering of blood uric acid levels with a benzothiazolyl derivative
DK0393534T3 (da) Farmaceutisk virksomme pteridinderivater
AU4441593A (en) Tetrahydronaphthalene derivatives, their preparation and their application in therapy