ZA927499B - Cyclic-substituted imidazolyl-propenoic acid derivatives. - Google Patents

Cyclic-substituted imidazolyl-propenoic acid derivatives.

Info

Publication number
ZA927499B
ZA927499B ZA927499A ZA927499A ZA927499B ZA 927499 B ZA927499 B ZA 927499B ZA 927499 A ZA927499 A ZA 927499A ZA 927499 A ZA927499 A ZA 927499A ZA 927499 B ZA927499 B ZA 927499B
Authority
ZA
South Africa
Prior art keywords
cyclic
acid derivatives
propenoic acid
substituted imidazolyl
imidazolyl
Prior art date
Application number
ZA927499A
Other languages
English (en)
Inventor
Thomas Kraemer
Juergen Dressel
Rudolf Hanko
Walter Huebsch
Ulrich Mueller
Matthias Mueller-Gliemann
Martin Beuck
Stanislav Kazda
Johannes-Peter Stasch
Andreas Knorr
Stefan Wohlfeil
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA927499B publication Critical patent/ZA927499B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA927499A 1991-10-01 1992-09-30 Cyclic-substituted imidazolyl-propenoic acid derivatives. ZA927499B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4132633A DE4132633A1 (de) 1991-10-01 1991-10-01 Cyclisch substituierte imidazolyl-propensaeurederivate

Publications (1)

Publication Number Publication Date
ZA927499B true ZA927499B (en) 1993-05-03

Family

ID=6441875

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927499A ZA927499B (en) 1991-10-01 1992-09-30 Cyclic-substituted imidazolyl-propenoic acid derivatives.

Country Status (14)

Country Link
US (1) US5225428A (OSRAM)
EP (1) EP0535465A1 (OSRAM)
JP (1) JPH05213937A (OSRAM)
KR (1) KR930007938A (OSRAM)
AU (1) AU646762B2 (OSRAM)
CA (1) CA2079266A1 (OSRAM)
CZ (1) CZ297792A3 (OSRAM)
DE (1) DE4132633A1 (OSRAM)
HU (1) HUT62578A (OSRAM)
IL (1) IL103292A0 (OSRAM)
MX (1) MX9205434A (OSRAM)
NO (1) NO923581L (OSRAM)
TW (1) TW206966B (OSRAM)
ZA (1) ZA927499B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
WO1995026188A1 (en) * 1994-03-29 1995-10-05 Merck & Co., Inc. Treatment of atherosclerosis with angiotensin ii receptor blocking imidazoles
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
US6465502B1 (en) * 1998-12-23 2002-10-15 Novartis Ag Additional therapeutic use
ES2332328T3 (es) * 2005-02-03 2010-02-02 Ratiopharm Gmbh Procedimiento para la preparacion de losartan.
EP1741711A1 (en) * 2005-07-04 2007-01-10 KRKA, D.D., Novo Mesto A process for the preparation of losartan derivatives by chlorination and reduction of the respective 1H-imidazole-5-carbaldehydes
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
HK1220696A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 鸟苷酸环化酶激动剂及其用途
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
CN107325052B (zh) * 2017-06-19 2020-01-10 广东药科大学 一类具有抗癌活性的咪唑酯类化合物及其衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0403158A3 (en) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
EP0955294B1 (en) * 1989-06-14 2003-09-24 Smithkline Beecham Corporation Imidazolyl-alkenoic acid
CA2060656A1 (en) * 1989-06-30 1990-12-31 Robert John Ardecky Substituted imidazoles
HU215834B (hu) * 1989-06-30 1999-04-28 E. I. Du Pont De Nemours And Co. Eljárás aromás csoporttal szubsztituált imidazolszármazékok, valamint ezeket hatóanyagként tartalmazó gyógyszerkészítmények előállítására
CA2027937A1 (en) * 1989-10-25 1991-04-26 Richard M. Keenan Substituted 5-¬ (tetrazolyl)alkenyl|imidazoles
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate

Also Published As

Publication number Publication date
HU9203125D0 (en) 1992-12-28
DE4132633A1 (de) 1993-04-08
CA2079266A1 (en) 1993-04-02
AU646762B2 (en) 1994-03-03
US5225428A (en) 1993-07-06
HUT62578A (en) 1993-05-28
AU2602592A (en) 1993-04-08
NO923581L (no) 1993-04-02
IL103292A0 (en) 1993-02-21
NO923581D0 (no) 1992-09-15
TW206966B (OSRAM) 1993-06-01
JPH05213937A (ja) 1993-08-24
CZ297792A3 (en) 1993-04-14
KR930007938A (ko) 1993-05-20
MX9205434A (es) 1993-04-01
EP0535465A1 (de) 1993-04-07

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