ZA923813B - Rapamycin derivatives - Google Patents

Rapamycin derivatives

Info

Publication number
ZA923813B
ZA923813B ZA923813A ZA923813A ZA923813B ZA 923813 B ZA923813 B ZA 923813B ZA 923813 A ZA923813 A ZA 923813A ZA 923813 A ZA923813 A ZA 923813A ZA 923813 B ZA923813 B ZA 923813B
Authority
ZA
South Africa
Prior art keywords
rapamycin derivatives
rapamycin
derivatives
Prior art date
Application number
ZA923813A
Other languages
English (en)
Inventor
Wenling Kao
Robert Lewis Vogel
John Henry Musser
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of ZA923813B publication Critical patent/ZA923813B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA923813A 1991-05-29 1992-05-25 Rapamycin derivatives ZA923813B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/706,821 US5120727A (en) 1991-05-29 1991-05-29 Rapamycin dimers

Publications (1)

Publication Number Publication Date
ZA923813B true ZA923813B (en) 1993-11-25

Family

ID=24839195

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA923813A ZA923813B (en) 1991-05-29 1992-05-25 Rapamycin derivatives

Country Status (10)

Country Link
US (1) US5120727A (fr)
JP (1) JPH05306289A (fr)
KR (1) KR920021556A (fr)
CA (1) CA2069468A1 (fr)
CZ (1) CZ156892A3 (fr)
FI (1) FI922432A (fr)
HU (1) HUT62904A (fr)
MX (1) MX9202546A (fr)
NO (1) NO922111L (fr)
ZA (1) ZA923813B (fr)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258389A (en) * 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
CA2155728C (fr) * 1993-02-12 2000-04-25 Gerald R. Crabtree Transcription regulee de genes cibles et d'autres evenements biologiques
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US6133456A (en) * 1994-08-18 2000-10-17 Ariad Gene Therapeutics, Inc. Synthetic multimerizing agents
US6150527A (en) * 1994-08-18 2000-11-21 Ariad Pharmaceuticals, Inc. Synthetic multimerizing agents
US20030036654A1 (en) 1994-08-18 2003-02-20 Holt Dennis A. Synthetic multimerizing agents
AU3367995A (en) * 1994-08-18 1996-03-14 Ariad Pharmaceuticals, Inc. New multimerizing agents
ATE465149T1 (de) * 1996-02-28 2010-05-15 Ariad Pharma Inc Synthetische rapamycinderivate als multimerisierende wirkstoffe für chimere proteine mit von immunophilin abgeleiteten domänen
US6890546B2 (en) * 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US20060198867A1 (en) * 1997-09-25 2006-09-07 Abbott Laboratories, Inc. Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US7399480B2 (en) * 1997-09-26 2008-07-15 Abbott Laboratories Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices
US20030129215A1 (en) 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
US7357942B2 (en) * 1997-09-26 2008-04-15 Abbott Laboratories Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens
US8394398B2 (en) * 1997-09-26 2013-03-12 Abbott Laboratories Methods of administering rapamycin analogs with anti-inflammatories using medical devices
US8057816B2 (en) * 1997-09-26 2011-11-15 Abbott Laboratories Compositions and methods of administering paclitaxel with other drugs using medical devices
US8257726B2 (en) * 1997-09-26 2012-09-04 Abbott Laboratories Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
US8257725B2 (en) * 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US7378105B2 (en) * 1997-09-26 2008-05-27 Abbott Laboratories Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
US7960405B2 (en) * 1998-09-24 2011-06-14 Abbott Laboratories Compounds and methods for treatment and prevention of diseases
US7455853B2 (en) * 1998-09-24 2008-11-25 Abbott Cardiovascular Systems Inc. Medical devices containing rapamycin analogs
US20060240070A1 (en) * 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
US8257724B2 (en) * 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6790228B2 (en) * 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US20070032853A1 (en) * 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
AU2001247401A1 (en) * 2000-03-14 2001-09-24 Genetics Institute Inc. Therapies that improve graft survival, using antibodies against a b7 antigen
AU2001249182A1 (en) * 2000-03-14 2001-09-24 Genetics Institute Inc. Use of rapamycin and agents that inhibit b7 activity in immunomodulation
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
US20080145402A1 (en) * 2001-09-10 2008-06-19 Abbott Cardiovascular Systems Inc. Medical Devices Containing Rapamycin Analogs
WO2003062773A1 (fr) * 2002-01-24 2003-07-31 Pei Electronics, Inc. Projecteur de scene infrarouge integre compact
US20060171984A1 (en) * 2002-09-06 2006-08-03 Cromack Keith R Device having hydration inhibitor
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
KR20060085246A (ko) * 2003-09-18 2006-07-26 마커사이트, 인코포레이티드 경공막 전달
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US20100030183A1 (en) * 2004-03-19 2010-02-04 Toner John L Method of treating vascular disease at a bifurcated vessel using a coated balloon
AU2005222719B2 (en) * 2004-03-19 2011-03-24 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
US20070027523A1 (en) * 2004-03-19 2007-02-01 Toner John L Method of treating vascular disease at a bifurcated vessel using coated balloon
US8431145B2 (en) 2004-03-19 2013-04-30 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
CA2571710A1 (fr) 2004-06-24 2006-11-02 Nicholas Valiante Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
CA2571899A1 (fr) * 2004-07-01 2006-08-03 Yale University Materiaux polymeres charges de medicaments cibles a forte densite
PL1848431T3 (pl) 2005-02-09 2016-08-31 Santen Pharmaceutical Co Ltd Ciekłe formulacje do leczenia chorób lub stanów
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
KR20070121754A (ko) * 2005-03-21 2007-12-27 마커사이트, 인코포레이티드 질환 또는 상태의 치료를 위한 약물 송달 시스템
EP1877004A4 (fr) 2005-03-23 2012-01-25 Abbott Lab Compositions et procedes pour l'administration d'analogues de rapamycine au moyen de dispositifs medicaux pour une efficacite de longue duree
JP5271697B2 (ja) * 2005-03-23 2013-08-21 アボット ラボラトリーズ 医療装置を介する高親油性薬剤の送達
AU2006311577B2 (en) 2005-11-09 2013-02-07 Zalicus Inc. Methods, compositions, and kits for the treatment of medical conditions
US7700614B2 (en) 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
CA2635797C (fr) * 2006-02-09 2015-03-31 Macusight, Inc. Formulations stables et leurs procedes de preparation et d'utilisation
US20070203169A1 (en) * 2006-02-28 2007-08-30 Zhao Jonathon Z Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same
US7622477B2 (en) * 2006-02-28 2009-11-24 Cordis Corporation Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same
US7678901B2 (en) 2006-02-28 2010-03-16 Wyeth Rapamycin analogs containing an antioxidant moiety
ES2563288T3 (es) 2006-03-23 2016-03-14 Santen Pharmaceutical Co., Ltd Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
US7883855B2 (en) 2006-07-21 2011-02-08 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
AU2007305423A1 (en) 2006-09-28 2008-04-10 Follica, Inc. Methods, kits, and compositions for generating new hair follicles and growing hair
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
WO2008083169A2 (fr) * 2006-12-26 2008-07-10 The Johns Hopkins University Compositions et procédés pour le traitement de troubles immunologiques
JP5481199B2 (ja) * 2006-12-27 2014-04-23 ザ ジョンズ ホプキンス ユニバーシティー 炎症および自己免疫疾患を治療するための組成物および方法
US20090142342A1 (en) * 2006-12-27 2009-06-04 Johns Hopkins University B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
US10265407B2 (en) 2007-02-15 2019-04-23 Yale University Modular nanodevices for smart adaptable vaccines
WO2008109347A2 (fr) * 2007-03-02 2008-09-12 Yale University Procédés d'administration ex vivo de médicaments à des greffons en utilisant des nanoparticules polymères
JP2008305262A (ja) * 2007-06-08 2008-12-18 Konica Minolta Business Technologies Inc サーバ及びシンクライアント環境でのプリンタ紹介方法
CN101946179B (zh) 2007-12-19 2014-08-13 雅培制药有限公司 用于免疫分析的免疫抑制剂药物提取试剂
US20090253733A1 (en) * 2008-04-02 2009-10-08 Biointeractions, Ltd. Rapamycin carbonate esters
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN104042612A (zh) 2008-11-11 2014-09-17 得克萨斯大学体系董事会 哺乳动物雷帕霉素靶蛋白的抑制
JP2013503205A (ja) 2009-08-31 2013-01-31 アンプリミューン, インコーポレイテッド 移植拒絶反応を阻害するための方法および組成物
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
US20170079962A1 (en) 2009-11-11 2017-03-23 Rapamycin Holdings, Llc Oral Rapamycin Preparation and Use for Stomatitus
WO2015103447A1 (fr) 2013-12-31 2015-07-09 Rapamycin Holdings, Llc Préparations orales de nanoparticules de rapamycine, et utilisation
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
US8951595B2 (en) * 2009-12-11 2015-02-10 Abbott Cardiovascular Systems Inc. Coatings with tunable molecular architecture for drug-coated balloon
US20110144577A1 (en) * 2009-12-11 2011-06-16 John Stankus Hydrophilic coatings with tunable composition for drug coated balloon
US8480620B2 (en) 2009-12-11 2013-07-09 Abbott Cardiovascular Systems Inc. Coatings with tunable solubility profile for drug-coated balloon
CN102844049B (zh) 2010-04-27 2016-06-01 罗切格利卡特公司 无岩藻糖基化CD20抗体与mTOR抑制剂的联合疗法
KR101253399B1 (ko) 2010-10-26 2013-04-11 영남대학교 산학협력단 아포지단백질 a-i 및 그 변이체를 포함한 재조합 고밀도지단백질을 이용한 라파마이신 제형
CA2852056C (fr) 2011-03-11 2021-08-10 Beth Israel Deaconess Medical Center, Inc. Anticorps anti-cd40 et leurs utilisations
EP2694520A1 (fr) 2011-04-01 2014-02-12 Sandoz AG Acylation régiosélective de la rapamycine au niveau de la position c-42
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
PL2836234T3 (pl) 2012-04-12 2020-02-28 Yale University Podłoża do kontrolowanego dostarczania różnych środków farmaceutycznych
EP2841098A4 (fr) 2012-04-23 2016-03-02 Allertein Therapeutics Llc Nanoparticules pour le traitement d'allergies
CN104203959B (zh) 2012-06-08 2017-09-15 百多力股份公司 雷帕霉素40‑o‑环状烃酯、组合物和方法
EP2906214A1 (fr) 2012-10-12 2015-08-19 The Board of Regents of The University of Texas System Utilisation d'inhibiteurs mtor pour traiter le déficit cognitif vasculaire
SG11201504764SA (en) 2012-12-19 2015-07-30 Amplimmune Inc Anti-human b7-h4 antibodies and their uses
US20160030401A1 (en) 2013-03-13 2016-02-04 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of intestinal polyp growth and cancer
CA2907915C (fr) 2013-04-03 2023-03-07 Allertein Therapeutics, Llc Compositions de nanoparticules immunomodulaires comprenant plusieurs nanoparticules composees de polymeres biodegradables ou biocompatibles et de composants cellulaires hydrophiles et hydrophobes
CA2912801A1 (fr) 2013-05-17 2014-11-20 Medimmune, Llc Recepteurs pour b7-h4
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
US10300070B2 (en) 2014-03-27 2019-05-28 The Brigham And Women's Hospital, Inc. Metabolically-activated drug conjugates to overcome resistance in cancer therapy
BR112016028211A2 (pt) 2014-06-02 2017-10-24 Childrens Medical Center métodos e composições para imunomodulação
EP3347794B1 (fr) 2015-09-04 2023-07-19 Yale University Nanocompositions d'acide biliaire polymère visant le pancréas et le côlon
MX2018002708A (es) 2015-09-04 2018-08-01 Primatope Therapeutics Inc Anticuerpos anti-cd40 humanizados y usos de los mismos.
US20190117799A1 (en) 2016-04-01 2019-04-25 The Brigham And Women's Hospital, Inc. Stimuli-responsive nanoparticles for biomedical applications
US10682340B2 (en) 2016-06-30 2020-06-16 Durect Corporation Depot formulations
CN115645399A (zh) 2016-06-30 2023-01-31 度瑞公司 长效配制物
US20210363240A1 (en) 2016-08-03 2021-11-25 Nextcure, Inc. Compositions and methods for modulating lair signal transduction
EP4360714A3 (fr) 2016-09-21 2024-07-24 Nextcure, Inc. Anticorps pour siglec-15 et leurs procédés d'utilisation
AU2017330346A1 (en) 2016-09-21 2019-02-21 Nextcure, Inc. Antibodies for Siglec-15 and methods of use thereof
EA201990127A1 (ru) 2016-12-30 2020-08-18 Дьюрект Корпорейшн Депо-препарат
EP3624863B1 (fr) 2017-05-15 2021-04-14 C.R. Bard, Inc. Dispositif médical à revêtement d'élution de médicament et à couche intermédiaire
WO2019217552A1 (fr) 2018-05-09 2019-11-14 Yale University Particules pour la libération spatio-temporelle d'agents
US20210115378A1 (en) 2018-05-09 2021-04-22 Yale University Compositions and systems for ex vivo cell modulation and methods of use thereof
US11541152B2 (en) 2018-11-14 2023-01-03 Lutonix, Inc. Medical device with drug-eluting coating on modified device surface
EP3911302A1 (fr) 2019-01-17 2021-11-24 Georgia Tech Research Corporation Systèmes d'administration de médicament contenant des cholestérols oxydés
JP7487228B2 (ja) 2019-04-08 2024-05-20 バード・ペリフェラル・バスキュラー・インコーポレーテッド 改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス
JP2023532204A (ja) 2020-06-19 2023-07-27 イェール ユニバーシティー 抗原特異的寛容を誘導する免疫調節剤を含むポリマー胆汁酸エステルナノ粒子
JP2024529341A (ja) 2021-07-15 2024-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 粒子が付着している細胞に関連する組成物および方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation

Also Published As

Publication number Publication date
NO922111D0 (no) 1992-05-27
JPH05306289A (ja) 1993-11-19
FI922432A0 (fi) 1992-05-27
KR920021556A (ko) 1992-12-18
CZ156892A3 (en) 1993-10-13
CA2069468A1 (fr) 1992-11-30
US5120727A (en) 1992-06-09
MX9202546A (es) 1992-11-01
FI922432A (fi) 1992-11-30
HUT62904A (en) 1993-06-28
HU9201782D0 (en) 1992-08-28
NO922111L (no) 1992-11-30

Similar Documents

Publication Publication Date Title
ZA923813B (en) Rapamycin derivatives
GB2247017B (en) Rapamycin derivatives
ZA935112B (en) Rapamycin derivatives
ZA935111B (en) Rapamycin derivatives
GR3023621T3 (en) 3-Hydroxy-4-aryl-5-oxo-pyrazolin derivatives
HU9203994D0 (en) Imidazo-pyridine derivatives
ZA935110B (en) Rapamycin derivatives
HU9202768D0 (en) Cyano-phenyl-pyrrole derivatives
GB9125842D0 (en) Heterocyclic derivatives
HU9202388D0 (en) Aryl-alkyl-amine derivatives
ZA92278B (en) 3-quinuclidine derivatives
GB9102804D0 (en) Heterocyclic derivatives
ZA922976B (en) 4-Aryl-3-heteroarylureidoquinoline derivatives
EP0520435A3 (en) Dc-89 derivatives
ZA938349B (en) Rapamycin derivatives.
AU1711492A (en) Rapamycin derivatives
HU9200011D0 (en) Trifluoro-methyl-1-carba(1-dethia)-cepheme derivatives
GB2262739B (en) Benzofuranylimidazole derivatives
GB9102423D0 (en) Pryimidinyl-and triazinylsalicyl-and-picolinylaldehyde derivatives
EP0519370A3 (en) Heterocyclic derivatives
HU9200105D0 (en) Bipiridyl derivatives
ZA915514B (en) Rapamycin derivatives
GB9106073D0 (en) Benzodioxanylimidazoline derivatives
GB9106070D0 (en) Benzodioxanylimidazole derivatives
GB9110611D0 (en) Pyrrolo-pyriding derivatives