KR920021556A - 라파 마이신 이량체 - Google Patents

라파 마이신 이량체 Download PDF

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Publication number
KR920021556A
KR920021556A KR1019920008967A KR920008967A KR920021556A KR 920021556 A KR920021556 A KR 920021556A KR 1019920008967 A KR1019920008967 A KR 1019920008967A KR 920008967 A KR920008967 A KR 920008967A KR 920021556 A KR920021556 A KR 920021556A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
substituted
rapamycin dimer
Prior art date
Application number
KR1019920008967A
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English (en)
Inventor
카오 웬링
루이스 보겔 로버트
헨리 머서 존
Original Assignee
이건 이. 버그
아메리칸 홈 프로덕츠 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 이건 이. 버그, 아메리칸 홈 프로덕츠 코포레이션 filed Critical 이건 이. 버그
Publication of KR920021556A publication Critical patent/KR920021556A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

라파 마이신 이량체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(I)의 라파마이신 이량체 또는 이의 약제학적으로 허용되는염.
    상기식에서, A는 -(CH2)n, -(CH2)n, -(CH=CH)-(CH2)m-, -(CH2)n-(-CH≡CH-)-(CH2)m- 치환된 알킬, 치환된 알케닐, 치환된 알키닐, 및 치환된 방향족이고, n은 1 내지 10이며, m은 1 내지 10이고, n과 m은 동일하거나 상이하다.
  2. 제1항에 있어서, A가 -(CH2)4-인 화합물 또는 이의 약제학적으로 허용되는 염.
  3. 제1항에 있어서, A가 -(CH2)5-인 화합물 또는 이의 약제학적으로 허용되는 염.
  4. 제1항에 있어서, A가 -(CH2)6-인 화합물 또는 이의 약제학적으로 허용되는 염.
  5. 제1항에 있어서, A가 -(CH2)7-인 화합물 또는 이의 약제학적으로 허용되는 염.
  6. 제1항에 있어서, A가인 화합물 또는 이의 약제학적으로 허용되는 염.
  7. 일반식(I)의 라파마이신 이량체인 화합물의 유효량을 투여함에 의해 포유동물에 조직이식 거부반응, 식피에 대한 숙주의 질환, 자가 면역 질환, 및 염증성 질환을 치료하는 방법.
    상기식에서, A는 -(CH2)n-, -(CH2)n, -(CH=CH)-(CH2)m-, -(CH2)n-(CH≡CH)-(CH2)m- 또는 치환된 알킬, 치환된 알케닐, 치환된 알키닐, 및 치환된 방향족이고, n은 1 내지 10이며, m은 1 내지 10이고, n과 m은 동일하거나 상이하다.
  8. 제1항의 화합물 또는 이의 약제학적으로 허용되는 염 및 약제학적으로 허용되는 담체를 포함하는 약제학적 조성물.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019920008967A 1991-05-29 1992-05-27 라파 마이신 이량체 KR920021556A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/706,821 US5120727A (en) 1991-05-29 1991-05-29 Rapamycin dimers
US07/706,821 1991-05-29

Publications (1)

Publication Number Publication Date
KR920021556A true KR920021556A (ko) 1992-12-18

Family

ID=24839195

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920008967A KR920021556A (ko) 1991-05-29 1992-05-27 라파 마이신 이량체

Country Status (10)

Country Link
US (1) US5120727A (ko)
JP (1) JPH05306289A (ko)
KR (1) KR920021556A (ko)
CA (1) CA2069468A1 (ko)
CZ (1) CZ156892A3 (ko)
FI (1) FI922432A (ko)
HU (1) HUT62904A (ko)
MX (1) MX9202546A (ko)
NO (1) NO922111L (ko)
ZA (1) ZA923813B (ko)

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US5120727A (en) 1992-06-09
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FI922432A0 (fi) 1992-05-27
FI922432A (fi) 1992-11-30
HUT62904A (en) 1993-06-28
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NO922111L (no) 1992-11-30
CZ156892A3 (en) 1993-10-13

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